Functional Changes in Mitochondrial Subpopulations of Left Ventricular Cardiomyocytes in Post-Infarction Rats During the Subacute Stage of Remodeling.
BACKGROUND: Cardiovascular diseases remain a leading cause of mortality worldwide, with myocardial infarction (MI) being the most severe form. Despite advances in treatment, MI is still associated wit...
Dietary Clusters and Mortality Risk in a Chinese Population: The Role of Type 2 Diabetes and Hypertension.
Background: Regional dietary variations in China are well-documented, but their mortality associations in local populations, particularly among individuals with type 2 diabetes (T2D) or hypertension, ...
Contemporary Endothelial Genome Editing Technologies: Towards Precision Genetic Medicine for Vascular Diseases.
Endothelial dysfunction is a key characteristic of many diseases, including atherosclerosis, hypertension, heart failure, stroke, cancer, acute respiratory distress syndrome (ARDS), peripheral vascula...
Angiotensin-Converting Enzyme 2 Overexpression Protects Heart from Aging-Induced Injury in C57BL/6 Mice.
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally among older adults. Similar to humans, age-related declines in cardiac function are observed in C57BL/6 mice. Angiot...
Integrative Transcriptomics and Machine Learning Identify Macrophage-Associated Biomarkers in Hypertrophic Cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease, with macrophages playing a critical role in its pathological remodeling. Our study aims to investigate the molecular basis of HCM b...
Calpain inhibition by calpeptin modulates adipocyte lipid metabolism and secretome-mediated inflammatory crosstalk with hepatocytes.
OBJECTIVE: Calpeptin, a calpain inhibitor with potential for treating inflammatory diseases, reduces extracellular vesicle (EV) secretion. While adipose tissue is a recognized target of calpeptin, its...
Histopathological Assessment of Myocardial Ischemia-Reperfusion Injury Using Transformer-Based Artificial Intelligence: Model Comparison Study.
BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) poses diagnostic challenges due to complex histopathological changes. OBJECTIVE: This study aimed to develop an intelligent framework for eval...
Patient Perceptions of a Digitally Enabled Community Health Worker Intervention: Qualitative Study Among Pilot Trial Participants.
BACKGROUND: Most studies assessing digital interventions for people with heart failure (HF) focus on clinical outcomes, and few include patient perspectives. Understanding patient experiences of the u...
Long-term outcomes of venous graft preservation in a rat autologous transplant model.
Venous grafts remain the most used conduits in coronary artery bypass grafting (CABG) but are highly susceptible to early failure due to ischemia-reperfusion injury, intimal hyperplasia, and accelerat...
Paclitaxel-coated balloon treatment is associated with sympathetic coronary denervation in a porcine model.
Drug-coated balloon (DCB) therapy promotes beneficial vascular remodeling after percutaneous coronary intervention. However, its mechanisms remain elusive. Given paclitaxel's neurotoxicity, the effect...
Dl‑3‑n‑Butylphthalide Protects the Blood-Brain Barrier in Neonatal Hypoxic‑Ischemic Brain Damage by Alleviating Endothelial Cell Ferroptosis via the SLC7A11/GSH/GPX4 Pathway.
Hypoxic-ischemic brain damage (HIBD) is a major contributor to neurological disabilities. Our previous studies have demonstrated that DL-3-n-butylphthalide (NBP) confers protective effects against HIB...
Transcriptomic characters of cochlear vascular cells with pericyte-driven angiogenetic activity.
The normal structure and function of inner-ear blood vessels, including the microvascular network of the stria vascularis (SV) within the blood-labyrinth barrier (BLB), are essential for auditory func...
Tocilizumab for severe immune checkpoint inhibitor myopathy-myocarditis: acute and long-term outcomes.
BACKGROUND: Immune checkpoint inhibitor (ICI)-myopathy-myocarditis is an immune-related adverse event, with high mortality despite first-line immunosuppression. Emerging data suggest upregulation of t...
Palliative Care in Advanced Heart Failure.
PURPOSE OF REVIEW: Advanced heart failure (HF) is characterized by high symptom burden, poor quality of life (QoL), and recurrent hospitalizations. As survival improves, an increasing proportion of pa...
Cytocompatible liquid crystal elastomer fibers for potential application as artificial skeletal or cardiac muscle.
To biomimetically mimic native muscle tissue new artificial soft actor materials need to be developed that can be processed into fibers and combine high mass-specific work, a sufficiently high contrac...
Modulation of depression through the neurobiological underpinnings of the glymphatic-rumination relationship.
BACKGROUND: Glymphatic functioning is implicated in cognitive and affective functioning. Given that rumination, a major risk factor for major depressive disorder (MDD), is a cognitive process regulati...
HDAC inhibition reprograms stem cell fate to suppress infantile hemangioma vasculogenesis.
Infantile hemangioma (IH), the most common vascular tumor of infancy, relies on hemangioma stem cells (HemSCs) to drive pathological vasculogenesis during the proliferating phase. While beta-blockers ...
Immunomodulatory Effects of Volatile Anesthetic Sevoflurane on Cardiomyocytes after Coronary Artery Bypass Grafting: Insights from Bioinformatics Analysis.
Volatile anesthetics, particularly sevoflurane, have demonstrated cardioprotective properties during cardiac surgery. However, their immunomodulatory mechanisms at the molecular level remain unclear. ...