Overview of findings from the UK and Ireland National Advanced Heart Failure Audit 2024.

BACKGROUND: Approximately one million individuals live with heart failure in the UK, and clinicians diagnose around 200 000 new cases each year. Although lifesaving treatments such as heart transplant...

Standardized End Point Definitions for Clinical Trials in Thoracic Aortic Repair: A Consensus Report From the ARCH-Academic Research Consortium.

Innovation in the treatment of ascending aorta and arch pathology with novel catheter-based and hybrid procedures has driven the need for a strategy to guide their safe application. The ARCH-ARC (Aort...

Extending the Reach of GLP-1 Receptor Agonists for Cardiovascular Risk Reduction.

Journal of the American College of Cardiology

ASSESSING THE EFFECTIVENESS OF LIFESTYLE CLINIC INTERVENTIONS ON CARDIOMETABOLIC RISK FACTORS: A RETROSPECTIVE STUDY.

BACKGROUND: Cardiometabolic disorders, including diabetes mellitus, hypertension, dyslipidemia, and obesity, represent a significant global health burden. While lifestyle interventions are recommended...

ASSESSMENT OF SUBCLINICAL RENAL INSULT IN SHORT- AND LONG-TERM UNCONTROLLED HYPERTENSION USING MOLECULAR BIOMARKERS OF NGAL AND KIM-1.

BACKGROUND: Uncontrolled Hypertension (UHTN) is a major cause of rapidly deteriorating kidney function. Typical clinical indicators often lack the sensitivity necessary for early detection of tubular ...

EFFICACY OF PERINDOPRIL IN PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION.

BACKGROUND/INTRODUCTION: Heart failure with reduced ejection fraction (HFrEF) represents a major global health burden, accounting for approximately half of all heart failure cases and characterized by...

SELECTIVE BRONCHIAL ARTERY CHEMOINFUSION IN NSCLC: CURRENT STATE OF REGIONAL THERAPY AND ITS ROLE IN MULTIMODAL APPROACHES.

UNLABELLED: Regional intra-arterial delivery of cytotoxic drugs into bronchial arteries (bronchial artery infusion - BAI; bronchial arterial chemoembolization - BACE; drug-eluting bead BACE - DEB-BACE...

ASSESSMENT OF VITEX AGNUS-COSTES PLANT EXTRACT ON THE HEART OF MICE EXPOSED TO OXIDATIVE STRESS.

Myocardial injury is largely the result of oxidative stress, which alters the structure and function of the heart's cardiomyaceous and conduction cells. The purpose of this investigation is to determi...

Adjunctive Cerebrolysin therapy following mechanical thrombectomy for acute basilar artery occlusion: a case report.

Basilar artery occlusion (BAO) is an uncommon yet devastating cause of posterior circulation stroke, frequently resulting in severe disability or death despite successful reperfusion. We describe a 67...

Impact of Angiotensin Receptor-Neprilysin Inhibition Combined with Enteral Nutritional Therapy on Cardiac Performance and Inflammatory Burden in Hemodialysis-Associated Heart Failure: Clinical and Experimental Evidence.

BACKGROUND: Cardiovascular complications remain the leading cause of mortality in patients undergoing maintenance hemodialysis (MHD), with heart failure (HF) representing a major clinical challenge. B...

Diagnostic value of cervical vascular ultrasound combined with CT angiography in carotid artery plaque in patients with cerebral infarction.

OBJECTIVE: To clarify diagnostic value of cervical vascular ultrasound (CVUS) combined with CT angiography (CTA) in carotid artery plaque in patients with cerebral infarction. METHODS: A total of 110 ...

Clinical severity of pulmonary Tuberculosis (TB) is associated with Hypocholesterolemia among adult patients in Uganda.

BACKGROUND: Hypocholesterolaemia in pulmonary tuberculosis(TB) patients is disregarded but is a predictor of poor survival. OBJECTIVES: To determine serum lipid profile differences at diagnosis and va...

[Analysis of Risk Factors and Construction of Predictive Model for Iliac Vein Compression Syndrome Combined with Deep Vein Thrombosis of the Lower Extremities].

OBJECTIVE: To explore the risk factors of lower extremity deep vein thrombosis (DVT) in patients with iliac vein compression syndrome (IVCS) and to construct a risk prediction model. METHODS: A total ...

A Complex Case of Systemic Sclerosis with Concurrent Breast Malignancy and Treatment-related Complications.

Systemic sclerosis (SSc) is a complex autoimmune disease marked by vasculopathy, fibrosis, and multisystem involvement. Interstitial lung disease (ILD) and pulmonary hypertension (PH) are major mortal...

Ask-Upmark Kidney: A Rare Cause of Hypertension in Young Patients.

Ask-Upmark kidney was originally described as a congenital segmental hypoplasia of the kidney, but recent data suggest it to be a sequela of vesicoureteral reflux or pyelonephritis in early age. This ...

Bidirectional Ventricular Tachycardia Culminating in Cardiac Arrest: A Diagnostic and Management Conundrum.

Bidirectional ventricular tachycardia (BDVT) is a rare arrhythmia marked by beat-to-beat QRS axis alteration. We report a 36-year-old female with recurrent palpitations who presented with BDVT degener...

AI-powered ECG Interpretation System for Arrhythmia Prediction and Hyperkalemia Detection Using Machine Learning.

BACKGROUND: Artificial intelligence (AI) has emerged as a powerful tool for electrocardiogram (ECG) analysis, potentially surpassing conventional interpretation in detecting arrhythmias and metabolic ...

Hydatid Cyst of Right Atrium.

A 70-year-old male presented with dyspnea New York Heart Association (NYHA) class II since 1994. Dyspnea was not progressive. There was no history of cough, fever, chest pain, or palpitation. He was i...

[Mechanistic study of Scutellariae Radix against atherosclerosis through inhibition of pyroptosis based on network pharmacology and experimental verification].

This study systematically investigated the mechanism of Scutellariae Radix against atherosclerosis(AS) through the integrated application of network pharmacology, molecular docking, and animal experim...

[Mechanism study of Zhizi Dahuang Decoction in treating atherosclerosis based on network pharmacology, molecular docking, and experimental validation].

This paper investigated the effects and mechanisms of Zhizi Dahuang Decoction(ZZDHT) in treating atherosclerosis(AS) through a comprehensive approach combining network pharmacology, molecular docking,...