Plain balloon angioplasty +/- bare metal stenting versus drug-coated balloon angioplasty +/- bare metal stenting versus primary drug-eluting stenting in patients with chronic limb-threatening ischaemia: BASIL-3, an open-label, three-arm, randomised, multi-centre, phase 3 trial.

OBJECTIVES: To determine which primary endovascular revascularisation strategy represents the most clinical and cost-effective treatment for patients with chronic limb threatening ischaemia who requir...

Effect of antihypertensive medication reduction on short-term blood pressure control in older adults: calibration of OPTiMISE trial results to real-world primary care data.

BACKGROUND: While antihypertensive treatment prevents cardiovascular events, it may also increase risks such as falls in patients with frailty. The Optimising Treatment for Mild Systolic Hypertension ...

Progressive reduction in complications of cryoballoon pulmonary vein isolation for atrial fibrillation.

AIMS: Cryoballoon pulmonary vein isolation (CB-PVI) has become an established treatment for atrial fibrillation and, recently, it has been proposed as first-line therapy for the treatment of paroxysma...

Prognostic value of preoperative peak atrial longitudinal strain for patients undergoing mitral valve surgery.

AIMS: In asymptomatic severe degenerative mitral regurgitation (MR), indications for surgery mainly rely on 2D echocardiographic criteria. Preoperative peak atrial longitudinal strain (PALS) has progn...

A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss.

A growing body of research suggests a link between immune system activation and the development of Parkinson's disease (PD). Previous work showed that repeated gastrointestinal infection with Citrobac...

Machine Learning Multiorgan Analysis of Coronary CT Angiography Body Composition, Myocardial Infarction, and Mortality in the SCOT-HEART Trial.

Background Coronary CT angiography provides prognostic information in addition to coronary findings. Purpose To evaluate associations between machine learning-derived multiorgan body composition and 1...

Functional Aerobic Capacity and Quality of Life in Patients with Heart Failure by Body Mass Index Category and Different Body Mass Index.

OBJECTIVE: Improved survival has been described in obese patients with heart failure (HF). However, whether this survival advantage is accompanied by better functional status has not been investigated...

Automated Deep Learning Quantification of Avascular Area and Intravitreal Neovascularization in Retinal Flatmounts of Rodent Oxygen-Induced Retinopathy Models.

PURPOSE: To develop a single deep learning model that quantifies the retinal avascular area (AVA) and intravitreal neovascularization (IVNV) in rodent oxygen-induced retinopathy (OIR) models. METHODS:...

Sigma 1 Receptor Activation Coordinates Metabolic Stress Responses to Protect Retinal Vasculature in Ischemic Retinopathy.

PURPOSE: Retinopathy of prematurity (ROP)-associated vision loss is driven by pathological retinal angiogenesis. Current therapies suppress neovascularization but do not fully restore vascular integri...

Upper gastrointestinal hemorrhage due to splenic artery pseudoaneurysm combined with pancreatic pseudocyst recurrence: A case report.

Intracapsular hemorrhage occurs occasionally in acute pancreatitis complicated with pseudocyst that can be managed using laparoscopic gastric cyst anastomosis and drainage. However, cyst recurrence ma...

The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.

PURPOSE: The purpose of this study was to investigate the effect of myopia on the optic disc morphology and retinal vascular geometry in anisometropic eyes. METHODS: This self-controlled study include...

Clinical characteristics of acupoint sensitization in patients with essential hypertension: a cross-sectional matched case-control study.

OBJECTIVE: To observe the characteristics of acupoint sensitization in patients with essential hypertension, analyze the mechanical pain threshold and tenderness threshold of each acupoint, and summar...

Ellagic Acid Attenuates Oxidative Stress and Improves Cardiovascular Function Following Myocardial Infarction in Ovariectomized Rats.

Oestrogen deficiency increases oxidative stress and reduces nitric oxide (NO) bioavailability, contributing to cardiac fibrosis following myocardial infarction (MI). This study investigated whether el...

Activation of the nucleus nuclear factor erythroid 2-related factor 2ghrelin/growth hormone secretagogue receptor 1a signaling by Yueju pill confers cardioprotective and antidepressant effects.

OBJECTIVE: To investigate the efficacy and mechanistic foundations of the Traditional Chinese Medicine Yueju pill (YJP, ) for treating the complex comorbidity of heart failure and depression. METHODS:...

Yiqi Huoxue formula relieves heart failure with reduced ejection fraction in calcium/calmodulin-dependent protein kinase Ⅱ delta B isoform and calcium/calmodulin-dependent protein kinase Ⅱ delta C isoform transgenic mice by inhibiting myocardial remodeling and enhancing calcium homeostasis.

OBJECTIVE: To confirm the efficacy of Yiqi Huoxue formula (, YQHX) on heart failure with reduced ejection fraction (HFrEF), and elucidate its potential effect on calcium homeostasis. METHODS: Cardiac ...

Hepatic portal venous gas in severe neurocritical illness after intracranial surgery: Two case reports and literature review.

Hepatic portal venous gas is an uncommon radiologic finding that has been rarely reported in neurocritical care settings. This article presents two clinically instructive case reports of severe neurol...

Risk factors and predictive nomogram model for late lumen restenosis following coronary drug-coated balloon angioplasty: An ambispective analysis.

OBJECTIVE: To determine the predictors of late lumen restenosis after coronary drug-coated balloon angioplasty, and to construct a nomogram-based clinical model to enhance prediction accuracy for late...

Shape and size of foveal avascular zone in normal subjects using optical coherence tomography angiography (OCTA) : A retrospective analysis.

OBJECTIVE: To determine the shape and size of foveal avascular zone in terms of perimeter, circularity, roundness and axial ratio using optical coherence tomography angiography. METHODS: The retrospec...

Clinicopathological profile, risk factors and outcome of adult biopsy-proven infection-related glomerulonephritis: A single centre prospective study.

OBJECTIVE: To assess the clinicopathological profile, risk factors and outcomes of biopsy-proven infection-related glomerulonephritis. METHODS: The prospective, cross-sectional, observational study wa...

Management of Meningioma invading Superior Sagittal Sinus: Surgery and Radiosurgery.

Parasagittal meningiomas that invade the superior sagittal sinus (SSS) pose a dual hazard: recurrence if tumour is left behind, and venous infarction if a functional sinus or bridging vein is compromi...