Histopathological and duplex characteristics of deep venous stents: A novel microsurgical small animal model.

BACKGROUND: Venous stent preclinical testing typically uses large animal models. We created two models of infrarenal inferior vena cava (IVC) stenting to study patency, flow rate, wall shear stress, a...

Transcriptomic profiling of varicose veins and associated blood biomarkers.

BACKGROUND: Intervention for patients with symptomatic varicose veins is largely driven by a combination of symptoms, the magnitude of venous reflux, clinical severity scoring algorithms, and unrespon...

Avermectin disrupts blood-brain barrier integrity in zebrafish larvae via the Wnt/β-catenin signaling pathway.

Avermectin, a widely used insecticide, has raised widespread concern over its potential toxic risk to non-target organisms. The safety of the nervous system occupies a crucial position in pesticide ri...

Influence of Fiber Dispersion Representation on the Accuracy of the Mechanical Response of Healthy and Aneurysmal Aortic Wall Tissue.

This study investigates the influence of fiber dispersion representation on the accuracy of the mechanical response of anisotropic hyperelastic material models for healthy and aneurysmal human aortic ...

Modulation of Systemic Osmolarity Alters Retinal Thickness and Schisis Cavities Without Blood Retinal Barrier Disruption in Rs1 Knockout Mice.

PURPOSE: The purpose of this study was to determine whether systemic osmolarity modulation through dehydration or hydration alters retinal thickness and schisis cavity area in Rs1 knockout (KO) mice c...

Aerobic exercise partially improves the skeletal muscle phenotype in a model of heart failure with preserved ejection fraction in male mice.

Heart failure with preserved ejection fraction (HFpEF) is associated with skeletal muscle dysfunction that contributes to exercise intolerance and disease progression. Altered Ca2+ homeostasis and inc...

Differential Influences of Achieved Blood Pressure on Cardiovascular Outcomes by Left Ventricular Geometries According to Chinese Ethnicity-Specific Echocardiographic Criteria for Hypertensive Patients.

Abnormal LV geometrics implied higher cardiovascular risk for hypertensive patients. Ethnicity-specific cardiographic criteria classified more accurately the left ventricular (LV) geometric patterns f...

Clinical outcomes of middle meningeal artery embolization in trauma-related chronic subdural hematoma.

BACKGROUND: Middle meningeal artery (MMA) embolization has emerged as a promising therapeutic option in the management of chronic subdural hematoma (cSDH). However, data specifically focusing on traum...

Comparative Effectiveness and Safety of Three Oral Antihypertensive Therapies on Maternal and Infant Outcomes in a California Medicaid Population, 2016-2020.

PURPOSE: To extend the Chronic Hypertension and Pregnancy (CHAP) trial findings, this study compared labetalol, nifedipine, and methyldopa initiation at or before 23 weeks' gestation in pregnant patie...

Atrial Fibrillation and Atrial Flutter in Pregnancy: Epidemiology, Pathophysiology, and Management.

IMPORTANCE: The prevalence of atrial fibrillation (AF) and atrial flutter (AFL) among pregnant patients has increased over time, with AF now being the most common sustained cardiac arrhythmia in pregn...

Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.

INTRODUCTION: Midlife hypertension is a well-established predictor of late-life cognitive decline; however, few population-representative estimates of this association exist among oldest-old cohorts. ...

Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.

PURPOSE: To examine changes in retinal perfusion density (PD) following short-term exposure to optically induced myopic defocus, an ocular growth-inhibitory stimulus, and achromatic digitally simulate...

Global Sensitivity Analysis for Studies Extending Inferences From a Randomized Trial to a Target Population.

When individuals participating in a randomized trial differ with respect to the distribution of effect modifiers compared with the target population where the trial results will be used, treatment eff...

MYO6 and Heart: A Novel Variant in a Deaf Infant With Supraventricular Tachycardia.

BACKGROUND: Variants in MYO6 are well known causes of hereditary deafness and have occasionally been linked to cardiac abnormalities, including hypertrophic cardiomyopathy and prolonged QT interval. H...

Impact of geometric factors and shear stress on endothelial function: Hemodynamic insights from human cerebral arterial bifurcations.

Vascular inflammation is not a random biological event but rather a process that is strictly regulated by physical forces. While biochemical mediators are well characterized, the local physical mechan...

Nanoparticles in Vascular Dementia: Advantages and Challenges.

BACKGROUND: Vascular dementia (VaD) is the second most prevalent form of dementia, accounting for 15%-20% of dementia cases and is primarily caused by cerebrovascular disorders. Current treatments pre...

Selective loss of Cx40 and conduction abnormalities underlie enhanced atrial fibrillation susceptibility in a HFpEF model in male mice.

Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), yet the mechanisms underlying AF vulnerability prior to or independent of extensive struct...

A c.89G>C p.(Gly30Ala) Variant in the DHCR7 Gene as a Cause of a Mild Phenotype in the Smith-Lemli-Opitz Syndrome.

BACKGROUND: Smith-Lemli-Opitz syndrome (SLOS) is a common autosomal recessive disorder caused by pathogenic variants in the DHCR7 gene, resulting in a deficiency of the enzyme 7-dehydrocholesterol red...

Machine Learning-based Model for Major Adverse Cardiac Event Prediction in Patients with Hypertrophic Cardiomyopathy.

Purpose To develop a machine learning-based model to identify patients with hypertrophic cardiomyopathy (HCM) at high risk of major adverse cardiac events (MACEs) and key predictors of model performan...

Coronary Artery Ectasia: A 10-Year Experience at a Single Center in Saudi Arabia.

OBJECTIVE: To assess the incidence of coronary artery ectasia (CAE) and its associated clinical characteristics and outcomes over a long follow-up period in Saudi Arabia. METHODS: We retrospectively a...