Exploration of SOCS3 and HSPA1A in PANoptosis during acute myocardial infarction and chronic kidney disease.

INTRODUCTION: Chronic kidney disease (CKD) is an independent risk factor for acute myocardial infarction (AMI), but the mechanisms underlying their comorbidity remain unclear. As a newly described inf...

Correlation Between Apolipoprotein B and Severity of Coronary Artery Stenosis in Individuals Aged 45 and Above: A Cross-Sectional Study.

BACKGROUND: Apolipoprotein B (ApoB) is widely recognized as a biomarker significantly associated with cardiovascular risk. However, the correlation between ApoB and the severity of coronary artery ana...

Endothelial epigenetic senescence driven microglial activation mediates cardio-retinal neuroinflammation in heart failure.

RATIONALE: Heart failure (HF) is increasingly recognized as a systemic disorder that extends beyond the heart and affects neurovascular tissues, including the retina. However, the mechanisms by which ...

CCR2 deficiency protects against doxorubicin-induced cardiac dysfunction through enhanced IL12B-dependent autophagy.

RATIONALE: Doxorubicin (DOX) is a potent chemotherapeutic agent whose antitumor benefits are limited by a well-recognized, dose-dependent cardiotoxicity. While previous studies have implicated inflamm...

Neural-immune-cardiovascular axis: from mechanistic crosstalk to therapeutic targets in cardiovascular disease.

The neural-immune-cardiovascular axis represents an emerging and highly integrated physiological and pathophysiological concept, describing a complex bidirectional communication network between the ne...

Prevalence, treatment rates and control of dyslipidemia among diabetes patients in northern Nigeria: A cross-sectional, multicenter study.

OBJECTIVES: Dyslipidemia is prevalent among Nigerians with diabetes mellitus (DM), but its treatment has not been well-studied. The objective of this study was to determine the prevalence, treatment r...

[The effect of acute heat injury on the morphological features of the cardio-pulmonary system].

Acute heat injury is one of the main triggers among exogenous factors affecting human vital functions and survival, especially in a changing climate. Despite this, the processes occurring in the human...

Evaluating cord blood S100B protein concentration as a potential biomarker associated with fetal hypoxia in late fetal growth restriction: A prospective cohort study protocol.

INTRODUCTION: S100B protein is a biomarker associated with central nervous system (CNS) injury following hypoxic-ischemic events. Measurement of S100B levels in umbilical cord blood may provide a noni...

Integrating Network Pharmacology and In Vitro Experiments to Elucidate the Antiatherosclerotic Mechanisms of Qingxin Tongmai Yin.

Qingxin Tongmai Yin (QXTMY), a classic traditional Chinese medicine (TCM) formula widely used for cardiovascular and cerebrovascular diseases, has unclear multitarget mechanisms against atherosclerosi...

Analysis of the Correlation Between Helper T-Lymphocyte Subsets and Atrial Fibrillation: An Observational and Mendelian Randomization Study.

BACKGROUND: Atrial fibrillation (AF) is the predominant arrhythmia. Growing evidence indicates that immunological diseases may play a role in its development. This study combined observational and gen...

State of the Art in Pericardial Disease: Webcast June 23 2026.

This 58-minute webcast features a conversation on the "State of the Art in Pericardial Disease"-the focus of Issue 22.2 on the theme of pericardial disease. Led by the issue's editor, the discussion e...

Bioinformatics and experimental studies of atherosclerosis-related endothelial dysfunction genes in renal calculi and exploration of their molecular mechanisms.

Patients with kidney stones (KS) often have an increased risk of atherosclerosis (AS). Because endothelial dysfunction (ED) is closely associated with AS, its role in KS remains unclear. This study ai...

Efficiency and hemodynamics of dual drainage venovenous ECMO: A computational parametric study.

Venovenous extracorporeal membrane oxygenation (VV ECMO) can be performed with different cannulation approaches: femoro-femoral (FF), femoro-jugular (FJ), or jugulo-femoral (JF), all characterized by ...

Complex Genomic Rearrangement Involving the TBX4 Promoter Manifesting With Variable Expressivity in a Five-Generation Family.

Variants involving TBX4 are associated with ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension (ICPPS; also known as small patella syndrome), pulmonary arterial hypertensi...

Linear dose-response relationship between TyG-WC index and diastolic dysfunction: insights from restricted cubic spline and machine learning analysis.

BACKGROUND: While diastolic dysfunction (DD) is a critical heart failure precursor linked to metabolic stress, the specific association between the promising triglyceride-glucose waist circumference (...

C-Myc Inhibition Using 10058-F4 Suppressed Ischemia Reperfusion Induced Cardiac Microvascular Endothelial Cell Pyroptosis through the Sam68/NF-κB Pathway.

Over the past few decades, most cardiac reperfusion research has focused on the pathogenesis of myocardial ischemia reperfusion injury (MIRI), while little attention has been paid to microvascular isc...

A New Mechanism of ox-LDL-Induced Endothelial Cell Pyroptosis.

Endothelial cell pyroptosis is a key factor promoting plaque instability in atherosclerosis (AS). Serum/Glucocorticoid Regulated Kinase 1 (SGK1) is upregulated in AS, but its upstream regulatory mecha...

A Concomitant Off-Pump Coronary Artery Bypass to TAV-in-TAV in a Patient with a High Risk of Coronary Artery Occlusion.

We report a case of a 90-year-old woman with prior transcatheter aortic valve replacement (TAVR) who presented with symptomatic structural valve deterioration. Imaging revealed a critically short valv...

Association between Circulating Interleukin-2 and Clinical Outcomes in Patients with Acute Decompensated Heart Failure.

Inflammation plays a critical role in the pathogenesis of acute decompensated heart failure (ADHF), and circulating inflammatory cytokines have been implicated in heart failure pathophysiology and pro...

[Anemia Assessment Using Aortic Attenuation on Dual-energy CT].

PURPOSE: This study aimed to evaluate the relationship between computed tomography (CT) attenuation values obtained from virtual monochromatic images (VMI) and virtual non-contrast (VNC) images genera...