Cellular expression domains of type 3 deiodinase in the meninges, choroid plexus, tanycytes and barrier tissues of the brain.

Thyroid hormone is required for brain development but under constraint because its unregulated action can damage target tissues. Type 3 deiodinase, a thyroid hormone-degrading enzyme encoded by Dio3, ...

Exploring the potential of community health workers in type-2 diabetes and hypertension management in Cambodia.

The burden of type-2 diabetes (T2D) and hypertension (HTN) in Cambodia is a major concern. The government and donors have introduced several interventions, yet human resource shortages hamper their im...

Proteomics risk scores and mortality in heart failure: Generalizability across populations.

BACKGROUND: Heart failure (HF) is a complex syndrome with high mortality. Proteomics risk scores have shown promise in predicting mortality beyond guideline-recommended clinical tools. It is crucial t...

Effects of Vericiguat on Peripheral Vascular Function and Resting/Exercise Hemodynamics in Patients With Heart Failure With Reduced Ejection Fraction: An Exploratory Pilot Study.

BackgroundVericiguat improves outcomes in heart failure with reduced ejection fraction (HFrEF), but its vascular and hemodynamic effects remain unclear. We explored changes in flow-mediated dilation (...

Subtype-Specific Associations Between Hyperlipidemia and Age-Related Cataract: A Clinic-Based Cross-Sectional Study.

BACKGROUND: Age-related cataract (ARC) is the leading cause of global blindness in the elderly. An unbalanced metabolic state is known to contribute to lens epithelial cell dysfunction and ARC pathoge...

[Hypertrophic cardiomyopathy and implantable cardiodefibrillator: 25 years of follow up].

INTRODUCTION: The implantable cardiodefibrillator (ICD) is the best available treatment for patients with hypertrophic cardiomyopathy (HCM), survivors or at high risk of sudden cardiac death (SCD). Th...

[Clinical and functional characteristics of patients with interstitial lung disease and pulmonary hypertension from a specialized lung disease center in Buenos Aires].

INTRODUCTION: Pulmonary hypertension (PH) associated with interstitial lung disease (ILD) represents a clinical phenotype of high morbidity and mortality. Early identification is essential to optimize...

Inhaled nitric oxide in fibrotic and advanced interstitial lung disease: A systematic review and meta-analysis of randomized controlled trials.

PURPOSE: Interstitial lung disease (ILD) can lead to pulmonary hypertension (PH), contributing to reduced exercise capacity in patients with ILD. Inhaled nitric oxide (iNO) reduces pulmonary artery pr...

Reappraisal of a historical porfimer sodium photodynamic therapy study for vascular restenosis: Efficacy, high procedural mortality, and methodological insights from a rabbit balloon-injury model.

BACKGROUND: Restenosis driven by intimal hyperplasia remains a major limitation of peripheral arterial intervention. Photodynamic therapy (PDT) using porfimer sodium (Photofrin®) demonstrated promisin...

Lactate and Lactylation in Pulmonary Hypertension: Comprehensive Landscape and Future Perspectives.

Pulmonary hypertension (PH) is a progressive pulmonary vascular disease with a poor prognosis and limited treatment options. Emerging evidence suggests that metabolic reprogramming plays a central rol...

Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk.

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but can induce immune-related myocarditis (ICI-MC), a rare yet life-threatening toxicity. This review elucidates the cellular and mo...

Development and validation of a nomogram model for predicting cardiac autonomic neuropathy in patients with diabetes.

BACKGROUND: Diabetic Cardiac Autonomic Neuropathy (DCAN), a critical yet frequently underdiagnosed microvascular complication, is associated with increased mortality. Standard cardiovascular autonomic...

A Thematic Analysis of Key Informant Interviews on the Implementation Experience of the HEARTS Hypertension Program in Nigeria.

The Nigeria Hypertension Control Initiative (NHCI) launched a national treatment program in 2020, guided by the HEARTS technical package for cardiovascular disease prevention in primary care. This stu...

Assessment of Blood Pressure Control Among Hypertensive Patients Attending Primary Healthcare Settings in Qatar: A Retrospective Chart Review.

AIM: Uncontrolled blood pressure (BP) poses a significant threat to public health, contributing to increased all-cause and cardiovascular disease (CVD) mortality.The study objectives were to assess BP...

Construction of a comprehensive value assessment framework for renal denervation therapy: a decision-support tool for Chinese hospital management.

OBJECTIVE: Renal denervation (RDN) therapy is an innovative interventional therapy for patients with refractory hypertension and antihypertensive drug intolerance. In China, four RDN products were app...

Application of digital health technologies in hypertension self-management: a narrative review.

Hypertension remains a major global public health challenge and a leading risk factor for cardiovascular morbidity and mortality. Effective long-term control of BP largely depends on sustained patient...

Genetic Evidence for the Benefits and Risks of Glucose-Lowering Drugs on Cardiovascular-Kidney-Metabolic Syndrome: A Drug-Target Mendelian Randomization Study.

BACKGROUND: To explore the potential benefits and risks of glucose-lowering drugs on cardiovascular-kidney-metabolic (CKM) syndrome outcomes using drug-target Mendelian randomization (MR). METHODS: Ge...

Multimodal Patient-Specific Identification of Atrial Flutter Circuits From ECG Time Series Using Explainable Machine Learning.

OBJECTIVE: Accurate pre-procedural identification of atrial flutter (AFL) mechanisms can streamline mapping and indirectly inform ablation strategy, yet surface-electrocardiogram (ECG) criteria remain...

PFKFB3 Mediated Glycolytic Reprogramming Drives Vascular Endothelial Injury Under Chronic Intermittent Hypoxia.

Metabolic-inflammatory crosstalk is a hallmark of cardiovascular pathogenesis. Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is an independent risk factor for car...

Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications.

Melatonin is a pleiotropic hormone with well-documented antioxidant, anti-inflammatory, neuroprotective, and immunomodulatory properties, making it a promising candidate for the treatment of diverse d...