Safety and efficacy of dual-axis rotational vs standard coronary angiography: meta-analysis.

The objective is to compare the safety and efficacy of dual-axis rotational coronary angiography (DARCA) with standard coronary angiography (SA). We performed a systematic review and meta-analysis com...

Data-driven atherosclerotic plaque profiles from QAngio-CT associated with functional impairments assessed with PET-CT.

OBJECTIVE: Although coronary artery disease (CAD) involves progressive atherosclerotic plaque dysfunction, further characterization of different cluster profiles and their impact on myocardial functio...

Integrated NEK7-inflammasome and platelet transcriptomic signature generates mechanistic hypotheses in heart failure.

BACKGROUND: The relationship between NEK7-NLRP3 inflammasome activation and elevated platelet activity in the progression of heart failure (HF) is not well understood. Additionally, a comprehensive ge...

Mechanisms of nephroprotective action of sodium-glucose cotransporter type 2 inhibitors.

OBJECTIVE: Aim: To study the potential mechanisms underlying the beneficial nephroprotective effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors. PATIENTS AND METHODS: Materials and Methods:...

Efficacy and safety of apixaban versus warfarin in LVAD patients: A propensity-matched analysis.

OBJECTIVE: Aim: The primary endpoint was the incidence of major HRAEs. Secondary endpoints included LVAD thrombosis, stroke, major bleeding, non-central nervous system thromboembolism, and all-cause m...

Association Between TNF-Alpha Levels and Atrial Fibrillation Outcomes: A Systematic Review and Meta-Analysis.

Background and objectivesPrevious studies suggest a link between tumor necrosis factor-alpha (TNF-alpha) levels and atrial fibrillation (AF). However, the nature of this relationship is disputed. To a...

Role and mechanism of nitric oxide-regulated cGAS/STING pathway-mediated inflammatory response in hypoglycemia-induced coronary artery endothelial cell injury.

BACKGROUND: Hypoglycemia in diabetes markedly increases the risk of coronary artery events, but the mechanism by which it damages vascular endothelium through nitric oxide (NO) regulation of innate im...

Systemic lupus erythematosus-driven accelerated atherosclerosis: the immune-metabolic-vascular axis and therapeutic implications.

Patients with systemic lupus erythematosus (SLE) are at markedly increased risk of premature atherosclerosis (AS) and atherosclerotic cardiovascular disease (ASCVD), and this excess risk is not fully ...

Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization.

INTRODUCTION: Patients with diabetes exhibit increased susceptibility to myocardial ischemia/reperfusion (IR) injury. Emerging evidence highlights gut microbiota-derived microbial metabolites as criti...

Patient quality of life determinants in decision-making regarding amputation.

BACKGROUND: Psychological adjustment to amputation begins well before surgery and is pivotal in determining both functional and emotional outcomes. For patients with Peripheral Arterial Disease (PAD),...

Knowledge of Hypertension and Self-Blood Pressure Measurement Skills in Spain.

BackgroundHypertension is a major cardiovascular risk factor that is insufficiently controlled. Management, which is challenging due to the asymptomatic nature of the disease and limited patient aware...

Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatment.

Avasimibe, a cholesterol-lowering drug with proven safety in clinical trials, has also been repositioned as an anticancer agent in various preclinical investigations. A study from our group reported t...

Novel right-angled origin and severe tortuosity of the right subclavian artery: a previously unrecognized challenge in transradial access.

BACKGROUND: The right subclavian artery typically originates from the lateral wall of the brachiocephalic trunk without tortuosity. Its anatomical variations pose significant challenges during transra...

In vivo immune engineering via mRNA therapeutics: reprogramming the post-infarction cardiac microenvironment.

Myocardial infarction (MI) initiates a biphasic immune response, which plays a critical role in determining whether the heart undergoes adaptive repair or progresses to pathological fibrosis. Traditio...

Implications of systolic pulmonary artery pressure trajectories in systemic lupus erythematosus-associated pulmonary hypertension: a CSTAR-PAH cohort study.

OBJECTIVE: To identify the evolution trajectory of systolic pulmonary artery pressure (sPAP) in patients with systemic lupus erythematosus-related pulmonary arterial hypertension (SLE-PAH) and to eval...

High systolic blood pressure and stroke: evidence from the NHANES 1999-2023 and global burden of disease 2021.

High systolic blood pressure (HSBP) is a major modifiable risk factor for stroke, but trends in disease burden and causal associations related to HSBP in the United States require further investigatio...

Prevalence of heart failure and coronary artery disease in older adults experiencing homelessness: A systematic review and meta-analysis protocol with a consultative exercise.

BACKGROUND: Heart failure (HF) is a major global public health challenge and a leading cause of morbidity and mortality, particularly among older adults. The rising prevalence of HF is driven by aging...

Biomarkers in heart failure.

Heart failure (HF) is a leading cause of morbidity and mortality worldwide, characterized by a complex pathophysiology and heterogeneous clinical trajectories. Circulating biomarkers have progressivel...

Pinolenic Acid Inhibits Prostanoid TP Receptor-Mediated Contraction in Porcine Coronary Arteries.

Pinolenic acid (PA), an 18 : 3 n-6 polyunsaturated fatty acid abundant in pine nut oil, is a structural isomer of γ-linolenic acid (GLA) and α-linolenic acid (ALA). Notably, GLA and ALA have been repo...

Family support mediates the relationship between medication adherence and quality of life among patients with hypertension in Ghana: A cross-sectional study.

BACKGROUND: Hypertension poses significant challenges to quality of life globally. While medication adherence is essential for managing hypertension, psychosocial factors like family support may influ...