Best available evidence for the management of oxaliplatin-induced hypersensitivity reactions, with implications for hepatic arterial infusion chemotherapy (HAIC).
PURPOSE: Oxaliplatin is widely used to treat gastrointestinal and hepatobiliary cancers, yet hypersensitivity reactions (HSRs) remain a significant safety concern in oncology. Although international g...
Cardiopulmonary instability score and in-hospital mortality in critically ill patients with cardiovascular disease: a retrospective eICU cohort study.
OBJECTIVES: To explore the association between a four-item cardiopulmonary instability (CPI) score assessed during the first 24 hours of intensive care unit (ICU) admission and in-hospital mortality a...
Walking a tightrope: the safety and efficacy of oral anticoagulants in atrial fibrillation patients with prior intracranial haemorrhage: a systematic review and meta-analysis.
INTRODUCTION: The optimal anticoagulation strategy for patients with atrial fibrillation (AF) and prior intracranial haemorrhage (ICH) remains uncertain. Although direct oral anticoagulants (DOACs) ha...
Selective retinal arterial whitening in retinal astrocytic hamartoma in tuberous sclerosis.
This case report aims to describe and understand the mechanism behind the selective retinal arterial whitening in a case of retinal astrocytic hamartoma (RAH) associated with tuberous sclerosis comple...
Large-scale proteomics to identify novel biomarkers linking social determinants of health to heart failure risk.
Adverse social determinants of health (SDOH) associate with greater heart failure (HF) risk. Among 9879 community-based participants of the Atherosclerosis Risk in Communities (ARIC) cohort study, we ...
Electrocardiographic identification of drug effects: QT prolongation, arrhythmias, and clinical monitoring.
BACKGROUND: The electrocardiogram (ECG) remains the foremost non-invasive tool for detecting adverse drug effects on cardiac electrophysiology, encompassing QT interval prolongation, torsades de point...
A ciliated intravascular soft millirobot for multimodal in-flow collective manipulation.
The laminar nature of blood flow and the resulting boundary layer pose substantial challenges for transverse mass transport in blood vessels, limiting intravascular biomedical applications such as tar...
Integrated Multi-omics Reveals CDKN1A Suppression and Metabolic Regulation as Key Mechanisms of Huangqi Guizhi Wuwu Decoction Against Doxorubicin-Induced Cardiotoxicity.
The clinical utility of doxorubicin (DOX) is severely limited by dose-dependent cardiotoxicity, for which effective interventions remain scarce. Huangqi Guizhi Wuwu Decoction (HGWD) shows promising ca...
Feasibility of a novel multi-device robotic system for multiple neurointerventional procedures: pre-clinical validation in porcine models.
While the application of a robotic system in neurointerventional procedures has gained notable attention, the current robotic assistance is unsatisfactory. Therefore, we developed a novel robotic syst...
Potential Role of Circulating Biomarkers in Peripheral Artery Disease.
PURPOSE OF REVIEW: To review evidence on the role of circulating biomarkers associated with lower extremity peripheral artery disease (PAD) and adverse outcomes in people with PAD. RECENT FINDINGS: Th...
Left Ventricular Summit Ventricular Tachycardia Identified by Electrocardiographic Pattern Recognition and Managed With Radiofrequency Ablation.
BACKGROUND Left ventricular summit ventricular tachycardia (LVSVT) originates in the epicardium of the superior left ventricular wall, between the origins of the main coronary arteries, with character...
Roles of Ceramide Glucosyltransferase in Controlling Cerebral Microvascular Endothelial Integrity and Angiogenesis Post-Ischemia/Reperfusion.
Sphingolipids critically regulate microvascular integrity and function, but the role of glycosphingolipids in endothelial survival and angiogenesis remains poorly defined. Herein, we experimentally de...
Comparative outcomes of robot-assisted and open radical nephrectomy with inferior vena cava thrombectomy for renal cell carcinoma: a systematic review and meta-analysis.
For patients with renal cell carcinoma (RCC) complicated by inferior vena cava (IVC) tumor thrombus, radical nephrectomy combined with thrombectomy remains a key surgical option. Open radical nephrect...
Giant cell myocarditis: from immune pathogenesis to contemporary management.
Giant cell myocarditis (GCM) is a rare but devastating inflammatory cardiac disease characterized by rapid hemodynamic deterioration, malignant arrhythmias, and high rates of death or heart transplant...
Hope for heart failure with preserved ejection fraction?
A common form of heart failure improves when cyclic guanosine monophosphate-dependent protein kinase is activated with a novel agent that promotes cysteine-42 oxidation.
Targeting PKGIα Cys(42) attenuates cardiac dysfunction in heart failure with preserved ejection fraction.
Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent condition associated with substantial morbidity and mortality, yet effective therapeutic options remain limited. As oxidati...
Histopathological analysis of a retrieved cerebral thrombus revealing occult lung adenocarcinoma: a case report.
BACKGROUND: Cancer-associated stroke (CAS) is a heterogeneous entity in which hypercoagulability represents the most common mechanism, whereas direct tumour embolism is rare and likely under-recognise...
Cardiopulmonary Failure in Hantavirus Disease: Mechanisms, Recognition, and ECMO-Based Management.
Background: Hantavirus pulmonary syndrome (HPS), also designated hantavirus cardiopulmonary syndrome, is caused by New World hantaviruses, principally Sin Nombre virus in North America and Andes virus...
Digital Rhythm Surveillance After Postoperative Atrial Fibrillation in Cancer Survivors: A Cardio-Oncology Survivorship Pathway.
Postoperative atrial fibrillation (POAF) after cardiac surgery is often managed as a transient inpatient arrhythmia, yet recurrent or silent atrial fibrillation (AF) after discharge may identify persi...
Panax ginseng C.A. Mey. as Multi-Target Regulators of Vascular Homeostasis: Pharmacological Mechanisms and Therapeutic Perspectives.
Cardiovascular and cerebrovascular diseases (CVDs) are closely associated with disturbances in vascular homeostasis, including endothelial dysfunction, abnormal vascular remodeling, inflammation, oxid...