Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study.
Atrial fibrillation (AF) is the most common clinical arrhythmia. Patients with paroxysmal atrial fibrillation (PAF) may exhibit reversible changes in atrial function at an early stage. Identifying bio...
A cerebrospinal fluid blood-brain barrier dysfunction score is associated with progression from mild cognitive impairment to Alzheimer's disease.
BACKGROUND: Blood-brain barrier permeability-related alterations are increasingly recognised as an early process in Alzheimer's disease, but their prognostic value and candidate molecular markers rema...
Synthetic versus biological patches for carotid endarterectomy.
RATIONALE: Extracranial carotid artery stenosis is a major cause of stroke. Carotid endarterectomy with patch angioplasty is a widely used surgical technique to reduce the risk of stroke in people wit...
USP10 mitigates Ang II-induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1.
Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular rol...
[Gastrointestinal metabolic surgery improves salt-sensitive hypertension via GLP-1-mediated inhibition of the RAS/NHE3 axis].
Objective: To investigate the effect of Roux-en-Y gastric bypass (RYGB) on salt-sensitive hypertension and its underlying molecular mechanism. Methods: (1) Clinical study: A total of 57 patients who u...
[Research progress on epigenetics of coronary artery calcification].
冠状动脉钙化是冠状动脉粥样硬化的高度特异性影像学标志，同时是冠心病预后不良的重要危险因素。表观遗传修饰在心血管疾病的发生发展中发挥重要的作用，主要通过DNA甲基化、组蛋白修饰以及非编码RNA调控等机制改变心血管稳态。该文从表观遗传学角度出发，结合不同表观修饰所介导的DNA甲基化、组蛋白修饰和非编码RNA等对冠状动脉钙化发病机制的影响进行综述，以期为冠状动脉钙化早期干预与精准防治提供理论依据与参考。...
[Metabolic associated fatty liver disease and myocardial ischemia in non-obese patients suspected of coronary artery disease].
Objective: To explore the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and myocardial ischemia in non-obese patients with suspected coronary heart disease (CAD), an...
[Research progress in myocardial metabolic reprogramming in atrial fibrillation].
心房颤动（房颤）是临床常见的心律失常，其病理机制涉及电重构与代谢调节网络的复杂相互作用。值得注意的是，房颤可引发显著的心肌代谢重编程，这种代谢稳态失衡不仅加速心房结构重构，更是维持颤动波持续传导的关键病理基础。该文系统阐述了房颤中心肌能量代谢障碍、脂质代谢失调、氨基酸代谢紊乱等核心代谢表型特征，以及线粒体功能障碍与氧化应激级联反应在其中的调控作用，并分别介绍不同类型的心脏细胞在房颤中的代谢重编程，...
[Research progress in the mechanism of coronary artery ectasia].
冠状动脉扩张是一类以冠状动脉管径异常扩张为特征的罕见病，其病因多样，发病机制尚未完全阐明，治疗手段有限，且预后不良。近年来国内外对该疾病的机制研究多聚焦于免疫炎症和细胞外基质降解两方面，但对不同病因所致冠状动脉扩张的发病机制的异同仍不清楚。为了加强对该疾病的认知、更好地指导临床诊疗，该文基于冠状动脉扩张的病因，对其发病机制予以总结和探讨。.
[Research progress in HIPPO signaling pathway in cardiovascular diseases].
心血管疾病（CVD）是全球范围内死亡的主要原因之一。成熟心肌细胞再生能力丧失是制约CVD临床疗效的关键障碍，心肌细胞发生损伤坏死后，心脏难以通过内源性增殖实现组织修复。HIPPO信号通路可调控心肌细胞增殖、肥大与死亡进程，在心肌损伤修复中发挥重要作用，有望改善心肌梗死后心脏泵血功能、减少恶性心律失常、延缓心力衰竭进展。该文综述HIPPO信号通路参与CVD发生发展的调控机制，为靶向干预该信号通路实现...
[Safety and efficacy of Laager left atrial appendage occlusion system in patients with nonvalvular atrial fibrillation: a prospective, multicenter clinical study].
Objective: To investigate the safety and efficacy of the Laager left atrial appendage occlusion system in stroke prevention in patients with atrial fibrillation. Methods: This was a prospective, multi...
The vision to develop a mechanical blood pump to support or replace the failing human heart was originally proposed in the late 1950s by Dr DeBakey. Since then, a portfolio of durable devices has been...
It remains unclear what the safe serum potassium range is in heart failure (HF) and whether it is the same in HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF).
Heart failure (HF) remains a major cause of morbidity, mortality and costs for the healthcare systems worldwide, despite advances in diagnostic and therapeutic strategies. The enhancement of preventiv...
Cardiac fibroblast (CF) activation in response to injury or inflammation is a central driver of pathological cardiac fibrosis, contributing to arrhythmias and heart failure. As previously demonstrated...
Hidden hypertension and early cardiac alterations: insights from ambulatory blood pressure monitoring in children and adolescents.
BACKGROUND: Hypertension is increasingly recognized as a significant health concern among children and adolescents, often associated with obesity and lifestyle choices. Early-onset hypertension can el...
Haemodynamic control of zonated liver function via instructive vascular Wnt signalling.
The vascular endothelium forms a systemically disseminated organ that translates micromilieu factors into instructive cues, designated as angiocrine signalling. While vascular control of organ functio...
Enhanced mitigation of diabetic myocardial injury in rats via modulating the adiponectin/IRS-1/PI3K/p-AKT/FOXO-1 signaling by combining methotrexate and insulin.
PURPOSE: The present study aimed to explore the impact of combining methotrexate (MTX) and insulin (INS) to mitigate diabetes-associated myocardial injury and investigate the potential underlying mech...
Evaluation of endothelial dysfunction in women with prolactinoma.
AIM: Prolactinoma has been associated with impaired glucose metabolism and adverse cardiometabolic outcomes. This study aimed to evaluate the metabolic effects of hyperprolactinemia and its impact on ...
Evaluating the endothelial glycocalyx from bench to bedside: a translational framework for microvascular assessment.
The endothelial glycocalyx (eGCX) plays a crucial role in mechanotransduction, maintaining vascular barrier integrity, and facilitating leukocyte-endothelial crosstalk. However, accurately quantifying...