Association of the atherogenic index of plasma and derived indicators with future risk of liver diseases and alcoholic liver disease among Chinese middle-aged and elderly adults: A nationwide cohort study.
The precise association between the atherogenic index of plasma (AIP) and its derived anthropometric indicators and the future risk of liver diseases and alcoholic liver disease among Chinese middle-a...
Association between hearing loss, tinnitus, and atherosclerotic cardiovascular disease among American adults: A cross-sectional study.
The interconnections between hearing loss, tinnitus, and atherosclerotic cardiovascular disease (ASCVD) remain incompletely elucidated. This study sought to investigate the associations of ASCVD preva...
Development and validation of a nomogram prediction model for mild pulmonary arterial hypertension risk in children with left-to-right shunt congenital heart disease.
Mild pulmonary arterial hypertension (PAH) represents an early and potentially reversible complication stage in children with congenital structural heart disease (CHD). Early identification of high-ri...
Predictive value of remnant cholesterol for in-stent restenosis after drug-eluting stent implantation.
In-stent restenosis (ISR) remains a major obstacle in percutaneous coronary intervention (PCI) in patients with coronary heart disease. Although previous studies suggest that remnant cholesterol (RC) ...
Iron overload cardiomyopathy.
Iron overload cardiomyopathy (IOC) remains an important cause of morbidity and mortality in patients with hereditary haemochromatosis and transfusion-dependent conditions such as haemoglobinopathies. ...
Identification of novel loci regulating circulating melatonin and its causal relationship with hypertension.
Melatonin exerts pleiotropic physiological functions and diverse disease associations, but its genetic architecture remains largely uncharacterized. Using low-coverage whole-genome sequencing (lcWGS) ...
Association of non-conventional lipid-inflammatory parameters with incident hypertension risk: a prospective cohort study.
BACKGROUND: Emerging research has associated non-conventional lipid indices with hypertension risk; however, the joint contribution of these lipid metrics and inflammatory biomarkers to hypertension s...
Are SGLT2 inhibitors really associated with increased urinary tract infection risk? A trial-level meta-analysis across type 2 diabetes, heart failure, and chronic kidney disease.
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are established therapies across the cardiovascular-renal continuum. Although the excess risk of external genital infection is well recogn...
Contemporary medical therapy for heart failure with mildly reduced or preserved ejection fraction.
Treatment for heart failure with mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) has evolved significantly in recent years. This period of therapeutic progress follow...
Ten-year incidence and heart failure dominance of hospitalized cardiovascular events in rheumatoid arthritis: a hospital-based cohort study from Martinique.
Higher risks of cardiovascular mortality and cardiovascular events have been reported in patients with rheumatoid arthritis (RA) compared with the general population. However, data remain scarce in po...
GPR75 mediates hyperuricemia-induced endothelial inflammatory injury via a HOTAIR/miR-141-3p regulatory network.
BACKGROUND: Hyperuricemia-related vascular endothelial injury is closely associated with hypertension, atherosclerosis, and other cardiovascular diseases. Although GPR75 has been implicated in vascula...
Temperature dependence of activation of thick and thin filaments in skeletal and cardiac muscles.
Contraction of striated muscle is initiated by an increase in the cytosolic Ca2+ concentration, which is regulated by tropomyosin and troponin on thin filaments in sarcomeres; viz., the binding of Ca2...
Morphoanatomical radiological analysis of pulmonary venous drainage patterns and left atrial morphology based on CT angiography.
PURPOSE: This study aimed to characterize the pulmonary venous (PV) drainage patterns and left atrial (LA) morphologies, and to perform a detailed morphoanatomic analysis based on computed tomography ...
Risk assessment and outcomes of systolic anterior motion in robotically assisted mitral valve repair.
Systolic anterior motion (SAM) is a known complication of mitral valve repair characterized by displacement of the anterior leaflet to the left ventricle outflow tract (LVOT) during systole leading to...
Exercise Preconditioning Activates AMPK-ACC Signaling and Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis.
Ferroptosis critically mediates myocardial ischemia/reperfusion (I/R) injury. Exercise training confers cardioprotection, but whether it protects against I/R-induced ferroptosis and the underlying mec...
Analysis of serum NMR metabolomics in fibrotic diseases of the myocardium.
INTRODUCTION: Heart failure accounts for more than 43% of annual deaths worldwide, and isdriven by widespread pathological remodeling, in which myocardial fibrosis plays an important role. Currently, ...
Accessory posterior cerebral artery-posterior cerebral artery anastomosis located just distal to the P1-P2 junction incidentally diagnosed by magnetic resonance angiography.
PURPOSE: To describe a case of an accessory posterior cerebral artery (PCA)-PCA anastomosis located just distal to the P1-P2 junction. METHODS: A 73-year-old man underwent cranial magnetic resonance (...
Carotid Free-Floating Thrombus: A Case Series, Narrative Review, and Proposal for Biology-Guided Treatment Selection.
Background: Carotid free-floating thrombus (CFFT) is an uncommon but clinically significant cause of transient ischemic attack and ischemic stroke, carrying a substantial risk of recurrent cerebral em...
Navigating the Complexity of PH-ILD: From Molecular Mechanisms to Integrated Clinical Evaluation.
Pulmonary Hypertension (PH) in patients with Interstitial Lung Disease (ILD) is a critical, yet underrecognized, complication that affects patients' quality of life and increases mortality. Emerging e...
Metabolic fatty acid substrates enhance the structural and mechanical performance of human-induced pluripotent stem cell-derived cardiomyocytes.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a powerful platform for disease modeling, drug discovery, and regenerative therapies. However, their clinical and research ...