Polysomnographic arousal index and periodic limb movement index in patients undergoing coronary artery bypass grafting: an exploratory case-comparison study.

PURPOSE: Obstructive sleep apnea (OSA) is a known risk factor for coronary artery disease (CAD), but its phenotypic variations and their impact on cardiovascular risk remain unclear. Recent studies su...

Empagliflozin Improves Endothelial Function in an Ovariectomized Rat Model of Estrogen Deficiency.

Cardiovascular disease risk increases after menopause, largely driven by estrogen deficiency-induced endothelial dysfunction. While sodium-glucose cotransporter 2 (SGLT2) inhibitors confer cardiovascu...

AI-Based Phenotyping of Atrial Fibrillation Through Generative Topographic Mapping: Prospective Murcia Atrial Fibrillation Project III Cohort Study.

BACKGROUND: The clinical heterogeneity of atrial fibrillation (AF) challenges current classifications and risk scores, limiting their real-world applicability. AI-driven methods may enhance phenotypin...

Extensive venous thromboembolism secondary to uterine fibroid compression of the inferior vena cava.

A woman in her 40s presented with a 2-day history of progressive left lower limb swelling and dyspnoea. She had a background of heavy menstrual bleeding and previously underwent insertion of an intrau...

Paediatric midaortic syndrome associated with ascending aortic and renal aneurysm managed with complex multidisciplinary medical management and surgical repair.

We present the case of an otherwise previously healthy female in middle childhood with severe renovascular hypertension secondary to midaortic syndrome with ascending aortic dilation. She presented wi...

"Heart-in-the-dish" models identify mechanisms of diastolic dysfunction.

Modeling of cardiac pathologies in tissue-engineered models is coming of age. Two independent studies by Reid et al.1 and Tani et al.2 present in-depth multi-phenomics data from a human cardiac organo...

FUNDC1-mediated mitochondrial quality control protects against immune checkpoint inhibitor-associated cardiac injury.

Immune checkpoint inhibitors (ICIs) targeting PD-1 are effective cancer therapies but can cause severe myocarditis. The molecular mechanisms linking PD-1 blockade to cardiomyocyte damage are incomplet...

Unexpected doornail hilar lymph nodes during robot-assisted pulmonary resection: intraoperative challenges and management strategies.

Hilar lymph nodes with dense adhesion to the bronchus and pulmonary artery ("doornail" nodes) can be encountered unexpectedly during robot-assisted pulmonary resection. We report our experience managi...

DTI-ALPS is not independently associated with overall survival beyond established prognostic factors in glioblastoma.

PURPOSE: Impaired glymphatic function has been associated with shorter survival in glioblastoma. However, the relationship between glymphatic dysfunction and survival has not yet been evaluated in the...

Granulomatous amoebic encephalitis: pathogenesis, diagnostic advances, therapeutic challenges, and emerging treatment strategies.

Granulomatous amoebic encephalitis (GAE) is a rare but highly fatal central nervous system infection caused primarily by Acanthamoeba spp. and Balamuthia mandrillaris. Delayed diagnosis and the absenc...

Role of the TLR4-NF-κB-FDX1 cuproptosis axis in mediating cognitive impairment associated with type 1 diabetes in children: an exploratory mechanistic study.

This study explored how the TLR4-NF-κB-FDX1 cuproptosis axis contributes to type 1 diabetes (T1DM)-related cognitive impairment, seeking to uncover novel intervention targets. Key genes were screened ...

Sphingolipids and Atherosclerosis.

PURPOSE OF REVIEW: We integrate evidences from human and mouse model studies which emphasize sphingolipid metabolism-mediated endothelium-lipoprotein-atherogenic plaque framework. The review may provi...

Endoscopic mitral valve replacement in extensive mitral annular calcification with a posterior pericardial patch.

Extensive mitral annular calcification represents a major technical challenge in mitral valve surgery and is associated with increased operative mortality and morbidity, including atrioventricular dis...

Aortic valve repair after atrial switch operation with autologous pulmonary artery wall.

Neoaortic valve repair after arterial switch operation can be challenging due to altered valve geometry and the absence of an ideal material for leaflet augmentation. We report repair of severe neoaor...

Peripheral Expression Profiles of Glutathione Reductase and miR-144 in Patients with Atrial Fibrillation.

Background: Atrial fibrillation (AF) is associated with oxidative stress and inflammation. Glutathione reductase (GR) and microRNA-144 (miR-144) may participate in redox-related pathways. This study a...

Short-term risk of recurrent stroke in symptomatic carotid near-occlusion: pooled analysis of three cohort studies.

INTRODUCTION: Carotid near-occlusion (CNO) is a severe carotid stenosis causing distal internal carotid artery (ICA) diameter reduction, classifiable as with or without full collapse. Whether full col...

Distinctive mortality patterns and the survival paradox in intracerebral haemorrhage subtypes: a 15-year longitudinal study.

INTRODUCTION: We investigated long-term outcomes, survival trajectories and cause-specific mortality in intracerebral haemorrhage (ICH) subtypes stratified by aetiology, location and recurrence status...

Lycium barbarum-Derived Extracellular Vesicles Ameliorate Myocardial Hypertrophy in Heart Failure with Preserved Ejection Fraction, Associated with Reduced Cardiomyocyte Apoptosis.

BACKGROUND: Non-invasive therapies for heart failure represent one of the current major focuses in clinical research. Plant-derived extracellular vesicles (PEVs) have recently emerged as a promising t...

Molecular mechanisms, therapeutic strategies, and inter-organ fibrosis crosstalk of Gla proteins in cardiovascular disease.

Gla proteins are a vitamin K-dependent family long studied for their roles in blood clotting and vascular calcification. This review examines their broader involvement in cardiovascular disease, parti...

Model-Assisted Prioritization of Gelatin Methacryloyl (GelMA) Hydrogel Formulations for Three-Dimensional Cell Culture.

Owing to highly tunable mechanics, gelatin methacryloyl (GelMA) hydrogels are widely exploited for three-dimensional (3D) cell culture, whereas limited experimental sampling restricts efficient formul...