Optimal Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention of the Left Main Coronary Artery: A Contemporary Narrative Review.

Background: The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) of the left main coronary artery remains uncertain because this lesion involves a la...

Endothelin Receptor Antagonists in Resistant Hypertension and Proteinuric Kidney Disease: Receptor Strategy and Volume Management.

This narrative review examines how endothelin receptor antagonists (ERAs) can be used at the intersection of difficult-to-control hypertension, chronic kidney disease (CKD), and albuminuria or protein...

Indoxyl Sulfate-Mediated Blood-Brain Barrier Damage in Chronic Kidney Disease.

Chronic kidney disease is associated with neurovascular complications including cognitive impairment, potentially involving blood-brain barrier (BBB) impairment. The protein-bound uremic toxin indoxyl...

T1R3 Anchors ACE2 at the Pulmonary Endothelial Cell Surface to Attenuate Vascular Injury Following SARS-CoV-2 Spike 1 Protein Exposure In Vitro.

The development of acute lung injury in COVID-19 patients is a major cause of lethality. Activation of the pulmonary vasculature, with inflammation, oxidative stress and barrier disruption, is initiat...

Hypertrophic Cardiomyopathy and the Risk of Bradyarrhythmia and Permanent Pacemaker Implantation: A Nationwide Cohort Study.

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is associated with various arrhythmias, including bradyarrhythmia. The relationship between HCM and bradyarrhythmia, and subsequent need for permanent pac...

eNOS Uncoupling, Shear-Stress Tolerance, and the Two-Threshold Model of Post-Exertional Malaise in Long COVID: A Mechanistic Hypothesis With Implications for Physiotherapy and Recovery Protocols.

OBJECTIVE: To propose and make testable a mechanistic hypothesis for post-exertional malaise (PEM) in a clinically distinct subset of Long COVID patients, in whom delayed exertional symptoms coexist w...

Case 353.

History An 8-month-old term-born female infant presented to the pediatric emergency department with progressively increasing respiratory distress and episodic hypoxic spells for 2 months. Antenatal an...

Antihypertensive effect of acupuncture involve reshaping gut microbiota and alleviating gut inflammation in spontaneously hypertensive rats.

OBJECTIVE: To investigate the antihypertensive effect and mechanism of acupuncture at Renying (ST9) and Zusanli (ST36) from the perspective of gut microbiota. METHODS: Eighteen male spontaneously hype...

Shear-Wave Elastography, Superb Microvascular Imaging, and B-mode US for Diagnostic Accuracy in Soft Tissue Tumors.

Background Differentiating benign from malignant soft tissue tumors (STTs) remains challenging, and conventional US alone is often insufficient. This study evaluated whether elastography and microvasc...

Mechanism of Yangxin Dawa Yimixike Mi Gao for myocardial ischemia/reperfusion injury: an integrative study of network pharmacology and and validation.

OBJECTIVE: To systematically elucidate the cardioprotective mechanisms of the traditional Uyghur polyherbal formulation Yangxin Dawa Yimixike Mi Gao (YXDW, ) against myocardial ischemia/ reperfusion i...

Therapeutic effect of Fuzheng Yixin decoction on cardiac insufficiencythe soluble guanylyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway in a doxorubicin-induced dilated cardiomyopathy rat model.

OBJECTIVE: To investigate the effect of Fuzheng Yixin decoction (, FZYX) and explore its underlying mechanisms in doxorubicin-induced dilated cardiomyopathy (DCM) rat model. METHODS: Sprague-Dawley ra...

Paeonol's protective effects on H9C2 cells against hypoxia/ reoxygenation injury through the hypoxia-inducible factor 1-alpha/B-cell lymphoma-2/adenovirus E1B 19 kDa interacting protein 3 signaling pathway.

OBJECTIVE: To elucidate the cytoprotective capacity of paeonol (PAE) against hypoxia/reoxygenation (H/R) injury in H9C2 cardiomyoblasts and to clarify its regulatory effects on the hypoxia-inducible f...

Retinal microvascular alterations and glymphatic dysfunction mediate the association between APOE ε4 and cognitive decline in Alzheimer's disease.

BACKGROUND: Vascular and glymphatic dysfunction are increasingly implicated in Alzheimer's disease (AD), particularly among apolipoprotein E (APOE) ε4 carriers. We investigated relationships among ret...

Longitudinal Patterns of Brain Parenchymal Damage Associated With the ALPS Index in a Community-Based Cohort.

AIMS: To better comprehend relationships between the analysis along the perivascular space (ALPS) index and glymphatic dysfunction, we assessed the spatiotemporal patterns of structural brain injury r...

[Lipid-lowering therapy in transition: implications of the ESC/EAS focused update].

In 2025, the focused update of the ESC/EAS guidelines on dyslipidemia management introduced clinically relevant refinements in cardiovascular risk stratification and lipid-lowering therapy. The update...

[Compression Syndromes: New Insights into the Arterial Thoracic Outlet Syndrome].

The arterial Thoracic Outlet Syndrome (aTOS) is a rare condition affecting approximately 4 per 100000 individuals per year, predominantly young and active patients. It results from compression of the ...

Disproportionality analysis of drug-induced myocarditis: Insights from the Food and Drug Administration Adverse Event Reporting System database.

ObjectiveDrug-induced myocarditis is a rare but serious adverse events that may have a significant impact on patient prognosis. To identify signals of disproportionate reporting associated with drug-i...

Temporal Trends in Preterm Birth Associated With Hypertensive Disorders of Pregnancy in Victoria, Australia: A Population-Based Interrupted Time-Series Study.

OBJECTIVES: Hypertensive disorders of pregnancy (HDP) are a leading reason for medically indicated preterm birth (PTB), yet their contribution to population-level PTB trends is poorly understood. We e...

Artificial Intelligence in Coronary Computed Tomography Angiography: A Bibliometric Analysis of Trends and Themes.

BACKGROUND: Artificial intelligence (AI) in coronary computed tomography angiography (CCTA) is increasingly recognized, but comprehensive bibliometric analyses on its integration are scarce. HYPOTHESI...

Correlation Between the High-Sensitivity C-Reactive Protein-to-Albumin Ratio and All-Cause Mortality in Patients With Acute Exacerbation of Chronic Heart Failure.

OBJECTIVE: To evaluate the correlation between the high-sensitivity C-reactive protein-to-albumin ratio (CAR) and all-cause mortality in patients with acute exacerbation of chronic heart failure (AECH...