Enhanced Pain Management With Combined EMLA Patch and Local Anesthetic Infiltration in Transradial Angiography.

BACKGROUND/OBJECTIVES: Pain at the radial access site remains common during coronary angiography. Evidence on topical anesthesia with EMLA patches is inconsistent, and the added value of combining EML...

Association of circulating miR-29b with microvascular dysfunction and digital ulcers in patients with systemic sclerosis: a single-centre pilot study.

OBJECTIVES: Systemic sclerosis is a rare autoimmune disorder marked by vasculopathy, immune dysregulation, and progressive fibrosis. Digital ulcers (DUs) reflect severe microvascular dysfunction. This...

[A novel extraction method and identification of primary mouse pulmonary artery smooth muscle cells].

Objective To establish an efficient and rapid primary culture protocol for mouse pulmonary artery smooth muscle cell (PASMC). Methods PASMC were isolated from mice using a novel dual-enzyme digestion ...

[PTPRO inhibitor alleviates cytoskeletal rearrangement and pyroptosis in brain microvascular endothelial cells in sepsis-associated encephalopathy via PI3K/AKT-related signaling].

Objective Sepsis-associated encephalopathy (SAE) is a common and severe complication of sepsis and is closely associated with blood-brain barrier (BBB) dysfunction and brain microvascular endothelial ...

Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review.

OBJECTIVE: The neurovascular unit (NVU) is a core structural and functional entity involved in migraine pathogenesis. Acupuncture may exert therapeutic effects by protecting NVU integrity. This narrat...

Post-Tracheostomy Fistula Formation Between the Trachea and Left Common Carotid Artery in a Pediatric Patient with Trisomy 18.

The long-term survival of individuals with trisomy 18 has improved, and the need for tracheostomy in this population has thus increased. We describe the case of a 3-year-old Japanese boy with trisomy ...

Phenotype-Dependent Effect of Bedtime Antihypertensive Dosing on Nocturnal Blood Pressure: A Meta-Analysis Guided by Non-Dipper Prevalence.

Bedtime dosing of antihypertensive medications is associated with a reduction in nocturnal blood pressure (BP), but whether this effect is modified at the study level remains uncertain. We conducted a...

Multimodal Neuroimaging-Based Machine Learning Models Leveraging Cerebral Morphometry and Glymphatic Parameters Predict Short-Term Post-Programming STN-DBS Motor Response in Parkinson's Disease.

BACKGROUND AND OBJECTIVES: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is effective for medication-refractory Parkinson's disease (PD) motor symptoms, but clinical response varies acro...

Temporal Trends in Multimorbidity Patterns in Patients With Atrial Fibrillation-A Nationwide Cohort Study.

BACKGROUND: The prevalence of both atrial fibrillation (AF) and multimorbidity is increasing with population aging. However, reliable and comprehensive data on temporal trends in multimorbidity among ...

Left Ventricular Pseudoaneurysm With Acquired Gerbode-Type Defect After Mitral Bioprosthetic Valve Replacement.

We present a 61-year-old woman with progressive dyspnea 20 days after mitral bioprosthetic valve replacement. Multimodality imaging revealed a left ventricular pseudoaneurysm rupturing into the right ...

Effects of Coffee Decaffeination on Beverage Bioactives, Antioxidant Activity, and Lipid Metabolism in Hyperlipidemic Rats.

The aim of this study was to evaluate the effect of chemical decaffeination on two coffee species (Coffea arabica and Coffea canephora) in terms of the chemical composition of filtered coffee beverage...

Non-Invasive Assessment of Left Ventricular Myocardial Work in Conditions Associated With Increased Left Ventricular Wall Thickness.

BACKGROUND: Left ventricular (LV) myocardial work (MW) assessment is a novel non-invasive tool for relatively load-independent assessment of LV myocardial contractile function. In this study, we compa...

One Year of Endurance Exercise Training Does not Improve Vascular Function in Non-Trained Limbs in Healthy Individuals.

Regular endurance exercise is widely recognized for its cardiovascular health benefits, with improvements in vascular function particularly relevant for populations with impaired vascular health. Howe...

Renin-Angiotensin System Inhibitor Use and Mortality in Older Hypertensive Patients With and Without Dementia: A Nationwide Registry-Based Cohort Study.

Cardiovascular risk factors are often undertreated in patients with dementia. Renin-angiotensin system inhibitors (RASI) are first-line treatments for hypertension. We examined the association between...

Twenty-Four-Hour Blood Pressure Variability Combined With Circadian Rhythm Patterns in Predicting Cardiovascular Events in Hypertensive Patients.

Short-term blood pressure variability (BPV) and circadian BP abnormalities are important cardiovascular risk predictors of mean BP levels, but their combined prognostic significance in essential hyper...

Estimated pulse wave velocity as an integrated hemodynamic risk indicator in obese women with gestational hypertension: A cross-sectional study.

Hypertensive disorders of pregnancy are associated with increased cardiovascular risk and arterial remodeling, further complicated by obesity. While carotid-femoral pulse wave velocity remains the gol...

Corylin Confers Vasoprotection via JDP2-Nrf2 Antioxidant Axis against Chronic Kidney Disease-Induced Smooth Muscle Cell Remodelling.

Vascular calcification is a pathological process involving vascular smooth muscle cells (VSMCs) phenotypic switching into osteoblast-like cells within a calcium phosphate-deposited environment. This t...

Prognostic Value of the Endothelial Activation and Stress Index (EASIX) in Critically Ill Patients With Ischemic Stroke: A MIMIC-IV Database Analysis.

BACKGROUND: Systemic endothelial dysfunction is a critical driver of poor outcomes in ischemic stroke. We evaluated the prognostic value of the endothelial activation and stress index (EASIX) in criti...

Advances of Fully Biodegradable Poly-p-Dioxanone and Polylactic Acid-Based Polymers as Left Atrial Appendage Closure Devices.

Atrial fibrillation (AF)-related ischemic stroke carries substantial clinical risks, and transcatheter left atrial appendage closure (LAAC) constitutes a core stroke preventive intervention. Conventio...

Maternal Hypertension, Diabetes, and Preterm Birth Risk Among Infants With Trisomy 21 in Texas, 1999-2018.

BACKGROUND: The preterm birth rate among infants with trisomy 21 is more than twice the rate among the general population. Maternal hypertension and diabetes are established risk factors for preterm b...