Impact of Thermodilution on Indexed Pulmonary Vascular Resistance Calculations in Pediatric Pulmonary Arterial Hypertension.

BACKGROUND: Accurate assessment of pulmonary vascular resistance index (PVRi) is essential for the diagnosis and management of pulmonary arterial hypertension (PAH). PVRi depends on pulmonary blood fl...

Methylation in the TAC1 Gene Promoter Is Associated with the Transition from Acute Pulmonary Embolism to Chronic Thromboembolic Pulmonary Hypertension.

Emerging evidence suggests that deoxyribonucleic acid (DNA) methylation may be linked to progression from acute pulmonary embolism (APE) to chronic thromboembolic pulmonary hypertension (CTEPH), espec...

Rethinking Mediterranean Diet Adherence and Body Composition: A 3-Year Prospective Observational Study in Patients with Type 2 Diabetes and Arterial Hypertension.

Background/Objectives: Type 2 diabetes mellitus (T2DM) and arterial hypertension (AH) frequently coexist and are major risk factors for cardiovascular disease (CVD) and chronic kidney disease. Althoug...

Sleep Circulation Time from Pulse Oximetry and Polysomnography: Predictive Value in Patients with Heart Failure with Reduced Ejection Fraction.

Background: This study evaluated the use of circulation time (Tcirc) calculated from polysomnogram (PSG) with pulse oximetry to identify poor cardiac function with low left ventricular ejection fracti...

Neurodegenerative and Cognitive Consequences of Long COVID.

The SARS-CoV-2 virus has infected approximately 778 million people worldwide since the pandemic. Patients who have survived coronavirus disease (COVID-19) may experience long-term symptoms related to ...

Cardiometabolic Aging Driven by Multi-Organ Crosstalk: Mechanisms and Therapeutic Strategies.

Cardiac senescence is not an isolated organ decline but a systemic consequence driven by pathological crosstalk between the heart and its peripheral metabolic organs. In this review, we discard the tr...

Ophthalmic Artery Doppler Indices and Maternal Factors in the Prediction of Preeclampsia in a High-Risk Obstetric Population: A Prospective Cohort Study.

AIM: To evaluate the utility of ophthalmic artery Doppler (OAD) indices, combined with maternal clinical factors, mean arterial pressure (MAP), and uterine artery pulsatility index (UtA-PI), for the p...

Right Ventricular Function and Pulmonary Arterial Coupling in Paediatric Obstructive Sleep Apnea.

PURPOSE: Right ventricular (RV) dysfunction and increased pulmonary arterial (PA) pressure may occur in children with obstructive sleep apnea (OSA). Long-term data on RV-PA coupling in children with O...

Development of a Diagnostic Model Based on Serum ST2 and Left Atrial Strain for Left Ventricular Systolic Dysfunction in Patients With Chronic Coronary Syndrome.

AIMS: The study investigated the predictive value of serum soluble ST2 (sST2) and left atrial strain parameters for left ventricular systolic dysfunction (LVSD), and the correlation analysis with corr...

Three-dimensional Speckle Tracking Imaging to Assess Subclinical Myocardial Mechanical Alterations in Patients With Type 2 Diabetes Mellitus Combined With Subclinical Hypothyroidism.

OBJECTIVE: This study aimed to evaluate subclinical myocardial mechanical alterations by utilizing three-dimensional speckle tracking imaging (3D-STI) in patients with type 2 diabetes mellitus (T2DM) ...

Differential Effects of Tafamidis on Cardiac Remodelling in Transthyretin Amyloid Cardiomyopathy: Evidence From Contemporary Imaging Data.

BACKGROUND: Tafamidis is the only approved disease-modifying therapy for transthyretin amyloid cardiomyopathy (ATTR-CM) in Australia. Although its clinical efficacy is established, its effects on card...

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults.

INTRODUCTION: Blood-brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau p...

Pretreatment Coronary Ultrasound Radiomics Combined With the Prognostic Nutritional Index for Predicting IVIG Resistance in Children With Kawasaki Disease.

BACKGROUND: Intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD) is associated with an increased risk of coronary artery injury and subsequent adverse cardiovascular out...

Pre-Transplant Left Atrial Volume Index and One-Year Morbidity After Kidney Transplantation.

OBJECTIVES: Pre-transplant echocardiography is routinely performed in kidney transplant candidates, although it remains unclear which parameters are associated with the broad spectrum of post-transpla...

Prognostic Value of Prolapse Width for Mid-Term Degenerative Mitral Regurgitation Stability After Transcatheter Edge-to-Edge Repair.

BACKGROUND: Long-term durability of degenerative mitral regurgitation (DMR) reduction after transcatheter edge-to-edge repair (TEER) remains limited, and reliable anatomical predictors are still lacki...

Genetic evidence linking circadian rhythm genes and hypertension: A two-sample Mendelian randomization study.

ObjectivesCircadian rhythms regulate human health, and observational studies have linked their disruption to hypertension; however, confounding factors and reverse causality limit causal interpretatio...

Durability of Blood Pressure Reduction After Renal Denervation in Resistant Hypertension: Mid-Term Real-World Outcomes From Kuwait.

Renal sympathetic denervation (RDN) has demonstrated blood pressure-lowering efficacy in randomized trials; however, long-term real-world data on durability and safety beyond the first year, particula...

Performance of Primary Aldosteronism Screening Tests Before Washout of Dihydropyridine Calcium Channel Blockers: An Exploratory Retrospective Study.

This retrospective cohort study preliminarily investigated the feasibility of implementing primary aldosteronism (PA) screening without discontinuing dihydropyridine calcium channel blockers (DHP-CCBs...

Purtscher-like retinopathy as a presenting ocular manifestation of biopsy-proven giant cell arteritis: A case report.

Purtscher-like retinopathy is a rare retinal microangiopathy characterised by sudden visual loss, cotton wool spots, retinal whitening and variable retinal haemorrhage in the absence of trauma. Giant ...

Impact of bicarbonate on ionized calcium and cardiac function in albumin-free Langendorff perfusion in hearts of male rats.

The adult Langendorff methodology lacks standardization, with inconsistencies in the pH and calcium concentrations of Krebs-Henseleit (K-H) solution. The aim of this study was to clarify these inconsi...