Daidzein Mitigates Nicotine-Induced Atherogenesis via Nrf2/ROS/TXNIP-Dependent Inhibition of Macrophage Pyroptosis and Lipid Accumulation.
Food-derived bioactive components play a crucial role in the prevention of cardiovascular diseases. Daidzein (DAI), a soy isoflavone, possesses notable cardioprotective potential; however, its precise...
A Case Report of Myocardial Infarction Complicated With Blood Pressure Fluctuations Caused by Pheochromocytoma.
Pheochromocytoma typically presents with sustained or paroxysmal hypertension, but initial manifestation as acute non-ST-segment elevation myocardial infarction (NSTEMI) is rare. Peri-procedural hemod...
Acute Myocarditis: From Pathophysiology to Risk-Stratified Management-A Clinical Review.
BACKGROUND: Acute myocarditis is an inflammatory disease of the myocardium with an annual incidence of 4-14 per 100,000 individuals, predominantly affecting young adults. Its clinical features are fre...
Superior Cardiorenal Protection With Tirzepatide Over Dulaglutide in Heart Failure With Preserved Ejection Fraction: A Large-Scale Propensity Score-Matched Real-World Analysis.
BACKGROUND: No direct head-to-head trials compare tirzepatide and dulaglutide in heart failure with preserved ejection fraction (HFpEF), though tirzepatide shows superior weight loss and potential car...
Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.
Drug-induced QTc prolongation (diQTP) is a major risk factor for torsades de pointes and sudden cardiac death. This study evaluated whether carriers of the G allele of the NOS1AP rs10494366 T > G vari...
Polarized Light Microscopy for Quantitative Assessment of Sarcomere-Scale Structural Order in Cardiac Tissue.
Polarization-resolved imaging provides a powerful, label-free means of visualizing anisotropic structural order in biological tissue, yet its quantitative exploitation remains limited in routine micro...
From protection to predisposition: A narrative review of sex-specific vascular responses to acute stressors across the lifespan.
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality, with females exhibiting relative biological protection against CVD compared to males through hormonal and nonhormonal m...
Beyond Left Ventricular and Left Atrial Strain: The Need for Comprehensive Four-Chamber Mechanical Assessment during the Preclinical Phase of Cardiovascular Disease.
The combined assessment of left ventricular global longitudinal strain and left atrial reservoir strain has recently demonstrated significant incremental prognostic value in patients with heart failur...
Agreement Between Standard and Right Ventricular-Focused Apical Four-Chamber Views for Right Ventricular Longitudinal Functional Indices: A Within-Participant Agreement Study.
PURPOSE: To determine whether right ventricular (RV) longitudinal functional indices measured from standard and RV-focused apical four-chamber (A4C) views are interchangeable at the individual level. ...
Sevoflurane Alleviates Myocardial Ischemia-Reperfusion Injury via the HMGB1/ACSL4 Pathway to Suppress Ferroptosis.
Sevoflurane (sevo) exhibits cardioprotective effects against myocardial ischemia/reperfusion injury (MIRI); however, its precise molecular mechanism of action remains elusive and warrants further in-d...
Assessment of Hemolysis, Icterus, and Lipemia Interference in 14 Clinical Chemistry and 5 Immunoassay Parameters.
BACKGROUND: Preanalytical interferences caused by hemolysis, icterus, and lipemia (HIL) remain major sources of diagnostic error in clinical laboratories. Manufacturer-declared cutoffs are often based...
Development and external validation of an online interpretable machine-learning model for predicting delirium risk in acute heart failure.
ObjectiveDelirium is a frequent complication in acute heart failure and is associated with poor outcomes in the intensive care unit. Machine learning methods can leverage high-dimensional clinical dat...
Unveiling the Th17/Treg Imbalance: a New Lens on Macular Perfusion in Thyroid-Associated Ophthalmopathy.
BACKGROUND: The aim of this study was to investigate the association between Th17/Treg imbalance and macular blood flow abnormalities in patients with thyroid-associated ophthalmopathy (TAO). METHODS:...
Early Hemolysis, Myolysis and Renal Stress Following Pentaspline Pulsed Field Versus Radiofrequency Ablation of Atrial Fibrillation.
BACKGROUND: Pulsed field ablation (PFA) is an effective alternative to radiofrequency ablation (RFA) for pulmonary vein isolation (PVI) in atrial fibrillation (AF), offering procedural advantages and ...
Supplemental oxygen induced cardiovascular pathophysiology in an end-of-life care model in mice.
Supplemental oxygen in critical care patients is associated with increased mortality. We previously reported hyperoxia-induces cardiac pathophysiology influenced by age, metabolic status, sex, and dur...
Contrast enhanced ultrasound and laser doppler flowmetry capture distinct aspects of tissue microvascular perfusion in nonhuman primates.
Microvascular perfusion in skeletal muscle (SkM) and subcutaneous adipose tissue (AT) is critical for insulin-mediated glucose uptake and is impaired in type 2 diabetes (T2D). Quantifying perfusion us...
Biofidelic Simulations of the Ross Procedure: Arterial Growth and Remodeling in an Anatomical Context.
The Ross procedure represents a promising alternative to conventional valve replacement techniques in young patients with aortic valve disease. Unlike mechanical or bioprosthetic substitutes, the pulm...
Ginger Supplementation and Blood Pressure in Adults: A GRADE-Based Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
BACKGROUND AND AIM: Ginger (Zingiber officinale L.) contains bioactive compounds with vasodilatory properties that may benefit blood pressure (BP) regulation. However, findings from studies remain inc...
Real-time GPU-accelerated coupled cardiac system: Integrating bidirectional interactions between living optogenetic monolayers and computational simulations.
OBJECTIVE: Reentrant arrhythmias are life-threatening cardiac events that are difficult to study due to limited experimental control over the complex circuit dynamics. We present a real-time coupled c...
Role of α-SMA, NOX4, Fibronectin, and HIF-1α in Pulmonary Microvascular Remodeling in COPD Patients Without Pulmonary Arterial Hypertension.
BACKGROUND: Pulmonary arterial hypertension (PAH) is a severe chronic obstructive pulmonary disease (COPD) complication, with vascular remodeling occurring early in disease progression. Oxidative stre...