Combined Left Ventricular and Left Atrial Strain Assessment for Long-Term Risk Stratification in Heart Failure With Reduced Ejection Fraction.

PURPOSE: Left ventricular (LV) global longitudinal strain (GLS) and left atrial reservoir strain (LASr) are established predictors of adverse outcomes in heart failure with reduced ejection fraction (...

Echocardiographic Phenomapping in HFpEF: From Imaging Biomarkers to Precision Cardiovascular Medicine.

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and clinically heterogeneous syndrome characterized by substantial variability in pathophysiology, disease prog...

Ejection Fraction in the Fast Lane.

Ventricular performance is typically evaluated on the basis of primary measurements such as pressure, volume and flow. Representative recordings obtained from a healthy, chronically instrumented consc...

Hypertension Control Rates Before and After Implementation of a Multicomponent Quality Improvement Program in Medicare Beneficiaries Primarily of Hispanic Origin in a Large Health System in South Florida, 2011-2018.

Health care systems have a key role in improving hypertension control in large populations, a global challenge, through the implementation of modern multicomponent programs. The impact of such program...

Microbiota-Neuroinflammation Crosstalk in Primary Brain Tumors: Focus on Glioblastoma.

PURPOSE: Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains difficult to treat because of diffuse invasion, immunosuppression, metabolic adaptability, and therapy resi...

Letter to the editor re: Sathya A, Nguyen TN, Klein P, et al. Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review. Interv Neuroradiol. 2024 Mar 22:15910199241231325.

Letter to the Editor re: Sathya A, Nguyen TN, Klein P, et al. Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review. Interv Neuroradiol. 2024...

Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium.

Aging involves the progressive decline of cellular function, yet the key molecular regulators that determine aging require further identification. Building on our previous finding that the intracellul...

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development.

Pathogenic variants in the genes encoding the non-canonical TGFB signaling components TAK1 (MAP3K7), TAB2 and PKA-Cα (PRKACA) cause rare multisystem disorders, which may include congenital heart disea...

Comparison of Second-line Hepatic Arterial Infusion Chemotherapy and Tyrosine Kinase Inhibitors in Advanced Hepatocellular Carcinoma.

Background With the advent of immune checkpoint inhibitor-based combination therapy, treatment sequencing for advanced hepatocellular carcinoma (HCC) has become increasingly complex. The Barcelona Cli...

Associations of Popliteal Artery Wall Morphology at MRI and Knee Osteoarthritis in the Osteoarthritis Initiative.

Background Vascular factors have been associated with osteoarthritis (OA), but the association between popliteal artery wall morphology and symptomatic and radiographic knee OA outcomes over time rema...

The Reliability and Validity of Manual Palpation to Assess Lower Limb Arterial Occlusion Pressure in Older Adults, for Application in Blood Flow Restriction Exercise.

(A) Investigate test-retest reliability of posterior tibial pulse palpation to determine arterial occlusion pressure (AOP) and examine validity against hand-held Doppler ultrasound. (B) Investigate th...

β3-AR/β-arrestin2 Interaction Triggers Cardiac Fibrosis Through JNK/c-Jun Pathway in Cardiac Fibroblasts.

Myocardial fibrosis (MF) is a critical pathological substrate of heart failure (HF), and β3-adrenergic receptor (β3-AR) has been implicated in cardiac remodelling with controversial roles. This study ...

Inhibiting HIF-1α-Induced miR-663b Improves Pulmonary Arterial Hypertension by Reducing Dysfunctions of PASMCs Through Repressing Sirt1-ZBP1-Mediated PANoptosis.

Pulmonary arterial hypertension (PAH) is a progressive disease characterised by vascular remodelling. Inflammatory responses and oxidative stress have been shown to contribute to its progression. This...

Assessing perceived social support in atrial fibrillation: Development and validation of an instrument to inform nursing care development.

BACKGROUND: Atrial fibrillation (AF) is associated with a significant clinical and psychosocial burden. It requires adequate informational, emotional, and functional support in addition to evidence-ba...

OCT-Defined Plaque Morphology and Clinical Outcomes After Percutaneous Coronary Intervention: An ILUMIEN IV Substudy.

BACKGROUND: Optical coherence tomography (OCT) can differentiate plaque morphology (fibrous, lipidic, and calcified) within atherosclerotic lesions. The prognostic impact of predominant OCT plaque typ...

The MagMa Study: Quantum Magnetocardiography in Cardiomyopathy.

BACKGROUND: Rapid diagnostic screening is an unmet need in patients with suspected cardiomyopathy (CM). The authors recently demonstrated in a retrospective study that magnetocardiography (MCG) may be...

Protective Effect of Isoflurane on Hypoxia/Reoxygenation-Induced Myocardial Injury via miR-548a-5p Regulation of PTEN.

Ischemia-reperfusion (I/R) injury induces cardiomyocyte apoptosis, oxidative stress and elevated myocardial injury markers. This study aimed to investigate whether the microRNA-548a-5p (miR-548a-5p)/p...

The Effect of Transpulmonary Pressure-Guided Positive End-Expiratory Pressure Titration on Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome Patients: A Single-Center, Randomized Controlled Pilot Pathophysiological Study.

OBJECTIVES: To compare the function of positive end-expiratory pressure (PEEP) titration guided by transpulmonary pressure (Ptp) with traditional lung-protective ventilation to optimize pulmonary arte...

Impact of Severe Postoperative Multi-Organ Dysfunction on Long-Term Outcomes After Modified Morrow Surgery.

BACKGROUND: The modified Morrow surgery is the gold standard surgical treatment for hypertrophic obstructive cardiomyopathy (HOCM). While effective, it carries a risk of postoperative severe multi-org...

Evaluation of AI-derived LAD artery dose metrics for survival stratification in stage III NSCLC: A secondary analysis of RTOG 0617 trial.

BACKGROUND: While the radiation dose to left anterior descending (LAD) artery is associated with overall survival (OS) in NSCLC patients, manual segmentation is labor-intensive. Several auto-segmentat...