The onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation.
Increased sympathetic tone and hypertension are hallmarks of metabolic syndrome and contribute to chronic kidney disease. Although renal sympathetic denervation transiently lowers blood pressure, its ...
Safety of multiple grasping attempts during transcatheter mitral valve repair with the PASCAL system.
BACKGROUND: Multiple grasping attempts are routinely required during mitral valve transcatheter-edge-to-edge repairs (M-TEER) to achieve optimal leaflet capture and minimize mitral regurgitation (MR)....
Oxadiazolone-Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II-Induced Vascular Contraction.
In this study, a series of novel angiotensin II type 1 receptor (AT1R) antagonist candidates containing the 1,2,4-oxadiazol-5-one nucleus and a 1,2,3-triazole moiety was designed, synthesized, and eva...
Discovery of Ro 41-0960, a Non-Steroidal Inhibitor of the Na(+)/K(+)-ATPase.
The Na+/K+-ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure. Yet, cardiotonic steroids used in clinical practice are limited by a narrow therapeu...
A Topological and Spatial Analysis of FDA-Approved Drugs, Blood-Brain Barrier Permeants, Natural Products, and Metabolites.
In this study, we present a comprehensive structural analysis of four distinct chemical libraries: FDA-approved drugs, blood-brain barrier (BBB) permeable agents, natural products (UNPDA), and human m...
YTHDF1-mediated m(6)A RNA regulation controls cardiomyocyte remodeling through KLF11-HIF1α.
Cardiovascular disease remains the leading cause of mortality globally. Although cardiac hypertrophy initially serves as a compensatory adaptation to stress, physiological and pathological hypertrophy...
Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease.
Atherosclerotic cardiovascular disease (ASCVD), the leading cause of mortality worldwide, is driven by endothelial cell (EC) inflammatory activation and counterbalanced by protective mechanosensitive ...
Individualized vs Standard Blood Pressure Control During Thrombectomy for Ischemic Stroke: The DETERMINE Randomized Clinical Trial.
BACKGROUND AND OBJECTIVES: Current recommended blood pressure (BP) targets during mechanical thrombectomy (MT) rely on a one-size-fits-all approach aiming at preventing hypertension. The efficacy and ...
Clinical Significance of the Hyperintense Reperfusion Marker and Ocular Gadolinium Leakage After Thrombectomy: A Retrospective ETIS Study.
BACKGROUND AND OBJECTIVES: Despite successful recanalization after mechanical thrombectomy for acute ischemic stroke, a substantial proportion of patients experience early neurologic deterioration or ...
GSK-3β in myocardial ischemia-reperfusion injury: molecular insights and therapeutic approaches.
OBJECTIVES: To synthesize current evidence on the role of glycogen synthase kinase-3β (GSK-3β) in myocardial ischemia-reperfusion injury (MIRI) and evaluate its potential as a therapeutic target. METH...
Co-Creation and Usability Testing of a Digital Cardiac Rehabilitation Program (eCardiacRehab): Design and Development Study.
BACKGROUND: Cardiac rehabilitation (CR) is a class IA-recommended treatment and secondary preventive strategy for people with coronary artery disease. eHealth solutions show promise in providing acces...
Cardiac implantable electronic devices in heart failure: needs, challenges, and real-world implementation.
Cardiac implantable electronic devices (CIEDs) are integral to heart failure (HF) management, providing therapies for bradyarrhythmias, cardiac resynchronization therapy (CRT), sudden cardiac death (S...
Partially Virtual vs In-Person Care in Cardiovascular Conditions-Time Trends, Patient Characteristics, and Medication Management: Cohort Study.
BACKGROUND: Despite growing initiatives to promote partially virtual care, there is still a lack of comprehensive data describing its use, patient characteristics, and medication management practices....
Electrocardiographic recording in horses at rest: a concordance analysis of two methods.
Cardiac arrhythmias are frequently detected during routine auscultation in athletic horses. Assessment of their clinical significance requires electrocardiography (ECG) to analyze waveforms and interv...
ORAI Ca(2+) channels and STIM1 drive capillary-to-arteriole communication in neurovascular coupling.
Neurovascular coupling (NVC), which is initiated by the brain's dense capillary network, matches blood flow to neuronal activity. We found that ORAI1 channels and their regulator STIM1, the main drive...
A mechanistic evaluation of sodium channel modulators in hiPSC-derived cardiomyocytes using fluorescence-based sodium flux imaging.
Drug-induced cardiotoxicity remains a significant challenge in pharmaceutical development. While patch-clamp remains the gold standard for evaluating ion channel effects, its low throughput limits ear...
Anticoagulation in Advanced Chronic Kidney Disease: Navigating Uncertainty.
Advanced chronic kidney disease (CKD) is characterized by a complex hemostatic state in which thrombotic and bleeding risks coexist. As kidney function declines, balancing thrombotic protection agains...
Axial Length-Associated Structural and Microvascular Retinal Changes in Myopia: A Combined OCT and OCTA Analysis.
PURPOSE: To evaluate associations between axial length (AL) and optical coherence tomography (OCT) and OCT angiography (OCTA) parameters, including vessel density (VD) in the superficial and deep macu...
Type I IFN signaling shapes subset-specific monocyte fates in the injured myocardium.
Monocytes and macrophages promote tissue repair following myocardial infarction, but the mechanisms tuning their effector functions remain elusive. While macrophages are essential in clearing debris a...
Fueling fibrosis: BCAT1 links branched-chain amino acid metabolism to collagen production.
Fibrosis remains a major driver of organ dysfunction, yet the metabolic programs that sustain extracellular matrix production are incompletely understood. In this issue of the JCI, Takizawa and collea...