PPARγ-Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis-Associated Encephalopathy in Mice.

OBJECTIVE: To assess whether pioglitazone (Pio) protects against sepsis-associated encephalopathy (SAE) and to probe underlying mechanisms. METHODS: Sepsis was induced in male C57BL/6 mice by caecal l...

ANGII Initiated HSF2 Trans-Activating HIF-1α Through Induction of ER Stress to Promote Cardiac Hypertrophy.

Heat shock factor 2 (HSF2) and hypoxia-inducible factor 1α are activated by angiotensin II (ANGII) in cardiomyocytes. The endoplasmic reticulum (ER) stress plays a critical role in cardiac hypertrophy...

ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles.

Despite advances in percutaneous coronary intervention, ischemia-reperfusion (IR) injury remains a major cause of morbidity and mortality. Adiponectin confers broad cardioprotective effects, motivatin...

Investigating Mitochondrial Bioenergetics in Intact Heart and Brain Tissue Slices.

Mitochondria are essential for maintaining the high energetic demands of the heart and brain, generating ATP required for contractile function, neuronal signaling, and ionic homeostasis. In both tissu...

Safety of Coadministration of Continuous Infusions of Propofol and Clevidipine: A Multi-Site Retrospective Analysis.

INTRODUCTION: Patients often receive propofol for sedation and clevidipine for hypertension in the intensive care unit. Both agents are formulated as a lipid emulsion, which may increase the risk of h...

First-Phase Ejection Fraction: A Novel Approach to Detecting Early Systolic Dysfunction in Hypertrophic Cardiomyopathy.

BACKGROUND: The assessment of stable coronary artery disease has been performed using the first-phase ejection fraction (EF1) in previous research. However, the use of EF1 has seldom been employed in ...

Risk of Heart Failure Hospitalization Associated With Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Versus Erythropoiesis-Stimulating Agents: A Nationwide Claims-Based Cohort Study.

PURPOSE: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are increasingly used to treat renal anemia in patients with chronic kidney disease (CKD). We evaluated the risk of heart fai...

Development of a Three-Layered Fascial Architecture in the Rabbit Carotid Sheath: Histological Findings Consistent With Mechanical Influences.

Current understanding of the fascial structures within the human carotid sheath (CS) is largely based on static anatomical descriptions, with limited knowledge of their dynamic developmental process. ...

Mitral Annular Calcification and Its Severity in Relation to Left Atrial Reservoir Strain and a Non-Invasive Left Atrial Stiffness Index.

PURPOSE: Mitral annular calcification (MAC) is associated with atrial fibrillation and diastolic dysfunction, but its relationship with left atrial (LA) mechanics is poorly defined. The ratio of E/e' ...

Three-Dimensional Transesophageal Echocardiographic Vena Contracta Area for Grading Mitral Regurgitation: Severity Cut-offs From a Prospective Tunisian Cohort.

BACKGROUND: Mitral regurgitation (MR) is among the most common valvular heart diseases, but its echocardiographic quantification remains challenging, particularly in secondary MR and in some organic c...

Fabrication of Mesoporous Manganese Nanoparticles Incorporated Aβ-Peptide Inhibits Aβ Aggregation and Alleviates Neuroinflammation Against Alzheimer's Disease.

Extracellular amyloid plaques from Aβ accumulation and intracellular neurofibrillary tangles (NFTs) from hyperphosphorylated Tau (p-Tau), both leading to neuronal dysfunction, synapse loss, and cognit...

An Improved Rat Model of Myocardial Infarction Without Invasive Intubation.

BACKGROUND/AIM: The standard surgical procedure for inducing myocardial infarction (MI) in rat models via left anterior descending (LAD) coronary artery ligation typically requires invasive endotrache...

High-sensitivity Cardiac Troponin I Changes Following Subcutaneous Needle Puncture, Restraint, and Venipuncture in Cynomolgus Monkeys.

BACKGROUND/AIM: Cardiac troponin I (cTnI) is a sensitive biomarker of myocardial injury in which procedure-related stress may cause mild, non-injury-related increases. This study aimed to characterize...

Neuropathy in Val122Ile Hereditary Transthyretin (ATTR) Amyloidosis: A Multicenter Retrospective Cohort Study.

BACKGROUND AND AIMS: The Val122Ile ATTR Amyloidosis has traditionally been linked to cardiac manifestations. Recent studies suggest that neuropathy may be relevant. In this study, we characterized its...

Diagnostic Performance of Coronary CT Angiography versus Invasive Coronary Angiography in Patients Undergoing Percutaneous Coronary Intervention: A Cross-Sectional Study.

OBJECTIVE: This study aimed to describe the diagnostic value of coronary computed tomography angiography (CCTA) compared with invasive coronary angiography (ICA) in patients with coronary artery disea...

Association between serum Total Antioxidant Status, Malondialdehyde and Coronary Artery Disease severity: A Cross-Sectional Study.

BACKGROUND: Reduced Total Antioxidant Status (TAS) and elevated Malondialdehyde (MDA) reflect redox imbalance in coronary artery disease (CAD). Their inverse relationship may help assess cardiovascula...

Digital Subtraction Angiography of the Prostatic Artery in Vietnamese Men: Anatomical Variants and Collateral Pathways. A Prospective Observational Study.

OBJECTIVE: To describe the origin, morphology, and branching patterns of the prostatic artery in Vietnamese men with symptomatic benign prostatic hyperplasia and to identify anatomical features releva...

Electrocardiographic Predictors of Early Recurrence of Atrial Fibrillation After Electrical Cardioversion.

BACKGROUND: Although electrical cardioversion (ECV) effectively restores sinus rhythm in patients with persistent atrial fibrillation (AF), early recurrence after successful ECV remains common in clin...

A recyclable antibody shield preserves LDL receptor homeostasis and enables durable lipid control without immune complex formation.

Soluble ligand-neutralizing antibodies are constrained by antigen excess and immune complex-associated toxicity. Here, we describe αLR-Ab, a humanized antibody that protects the low-density lipoprotei...

Neurological Adverse Events Associated With Immune Checkpoint Inhibitors Identified Through Disproportionality Analysis of the FDA Adverse Event Reporting System.

BACKGROUND: Neurological immune-related adverse events (N-irAEs) from immune checkpoint inhibitors (ICIs) are rare but potentially fatal. This study aimed to characterize their real-world profile to s...