[Comment on the article: "Changes in the triglyceride-glucose index after one year of antiretroviral therapy"].
Both HIV diagnosis and antiretroviral therapy (55.1%) increase the risk of developing lipid profile abnormalities. This has led the European Society of Cardiology, in its 2025 update on the management...
Arginase-2 enhances monocyte-endothelial interaction through regulation of integrin and membrane receptor expression: role in atherogenesis.
BACKGROUND: Circulating monocyte trans-endothelial migration is critical for vascular diseases. The monocyte surface proteins, i.e., integrins and membrane receptors are central in this process. Previ...
Nationwide Population-Based Cohort Study of Advanced Maternal Age and Obstetric Outcomes in Korean Women: Retrospective Cohort Study.
BACKGROUND: The proportion of mothers older than 35 years is increasing; however, research examining the age at which pregnancy is considered high risk across different races and countries is limited....
Impact of Kidney Function on the Treatment Effect of Multi-Arterial Grafting in CABG Patients.
BACKGROUND: The adoption of multi-arterial grafting (MAG) remains limited in real-world coronary artery bypass grafting (CABG) practice. This study aimed to identify subsets of patients most likely to...
Abbreviated DAPT Regimens Across the Entire Spectrum of Bleeding Risk According to the PRECISE-HBR Score.
BACKGROUND: Among high-bleeding risk (HBR) patients undergoing coronary stenting, abbreviated dual antiplatelet therapy (DAPT) reduces bleeding without ischemic risk trade-off; whether these benefits ...
Incidence of post-procedural atrial fibrillation after multivessel percutaneous coronary intervention versus coronary artery bypass grafting: a nationwide observational study.
BACKGROUND: Postoperative atrial fibrillation (AF) is a common complication after coronary artery bypass grafting (CABG) but is less well characterised after multivessel percutaneous coronary interven...
Synergistic reproductive toxicity of lambda-cyhalothrin and thiamethoxam via oxidative stress and blood-testis barrier dysfunction in rats.
Excessive pesticide use regularly pollutes the environment and endangers both human and animal health. The current study aimed to examine the main mechanism by which the combined action of pyrethroids...
Fractional Flow Reserve-Guided Renal Artery Stenting in Renovascular Hypertension: 1-Year Results of the FAIR Study.
BACKGROUND: Whether fractional flow reserve (FFR)-guided revascularization improves outcomes in atherosclerotic renal artery stenosis (ARAS) remains uncertain. OBJECTIVES: This study will evaluate whe...
Comparative Efficacy of Endovascular Revascularization Modalities for Symptomatic Infrapopliteal Peripheral Artery Disease: A Network Meta-Analysis.
BACKGROUND: Patients with infrapopliteal peripheral artery disease (PAD) are at elevated risk for amputation and mortality. The comparative efficacy of available endovascular devices for treating infr...
Procedural Strategies for Optimal Transcatheter Aortic Valve Replacement: An International Position Statement.
The extension of transcatheter aortic valve replacement (TAVR) to younger patients with longer life expectancy has driven a shift in focus toward procedural optimization, with the goals of maximal cli...
Anaesthetic management of a child with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) and supravalvular aortic stenosis (SVAS) associated with Williams-Beuren syndrome undergoing combined coronary reimplantation and supravalvular aortoplasty.
A child with genetically confirmed Williams-Beuren syndrome, having moderate supravalvular aortic stenosis, was diagnosed with anomalous origin of the left coronary artery from the pulmonary artery (A...
Vertex epidural haematoma secondary to sagittal sinus involvement: a surgical challenge.
Epidural haematomas (EDHs) involving the superior sagittal sinus (SSS) are rare and carry significant surgical risks. We report a man in his 50s who sustained an occipital head injury secondary to a t...
Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow: A Randomized Double-Blind Placebo-Controlled Mechanistic Study.
BACKGROUND: Nitrates remain a key drug class in the management of angina pectoris. However, their effect on coronary blood flow has never been convincingly demonstrated in humans. OBJECTIVES: The aim ...
AI Model Improves Interpretation of Cardiac Magnetic Resonance Imaging Scans.
Interpreting cardiac magnetic resonance imaging scans takes significant time and specialist expertise. In this News and Perspectives article, JMIR Correspondent Shalini Kathuria Narang reports on new ...
Pre- and post-operative metabolic profile of patients with pheochromocytoma: A retrospective multicenter study.
PURPOSE: To evaluate the metabolic dysregulation of patients with pheochromocytoma and their metabolic evolution after tumor resection. METHODS: This multicenter, retrospective study included individu...
Mitochondrial ncRNAs: From Pathological Regulation to Targeted Therapy in Cardiovascular Diseases.
Heart failure (HF) is closely linked to mitochondrial dysfunction, featured by abnormal energy metabolism, excessive reactive oxygen species (ROS), and imbalanced mitochondrial dynamics. Clinically, e...
Thyroid function and outcomes in heart failure with mildly reduced ejection fraction: insights from a large, retrospective registry.
OBJECTIVE: This study aimed to investigate the prognostic impact of thyroid function on the outcomes of patients with heart failure with mildly reduced ejection fraction (HFmrEF). BACKGROUND: Thyroid ...
Extracellular Vesicles in Stroke: Drivers of Brain-Body Network Crosstalk.
Mounting evidence reframes stroke not as a single cerebral event but as a dynamic brain-body network disorder. Extracellular vesicles (EVs)-lipid bilayer-enclosed particles released by virtually all c...
Exercise-Induced Complete Heart Block and Sinoatrial Exit Block in Baseline Bifascicular Block.
BACKGROUND Bifascicular block is typically asymptomatic and incidentally diagnosed, yet it may progress to advanced conduction disturbances. In patients with unexplained syncope and conduction abnorma...
Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis.
Breast cancer (BC) is closely linked to coronary heart disease (CHD), yet the genetic causal relationship and common driving mechanism between the two have not been fully elucidated. The purpose of th...