A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice.
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality in patients with insulin resistance, and new therapies are urgently needed. We previously developed an...
SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver.
The liver plays a major role in regulating the metabolic fate of lipids and facilitates lipid secretion to peripheral organs in the form of VLDLs or lipid storage in lipid droplets (LDs). Hepatic regu...
Clinical factors associated with retreatment and early coronary outcomes in Kawasaki disease in children aged < 6 months: a single-center cohort study.
UNLABELLED: To evaluate whether pre-treatment coronary artery aneurysm (CAA) Z-score, inflammatory markers, and incomplete Kawasaki disease (KD) status are associated with intravenous immunoglobulin (...
Ultrasound Identification of Right Internal Jugular Vein Occlusion After Catheterization in a Premature Infant.
BACKGROUND Right internal jugular vein (RIJV) catheterization is a routine clinical procedure for gastrointestinal surgery. The conventional blind puncture method is often unable to detect vascular an...
Incretin-Based Therapies in Doxorubicin-Induced Cardiotoxicity: A Systematic Review of GLP-1 and Dual GIP/GLP-1 Agonists.
Doxorubicin (DOX)-induced cardiotoxicity remains a major limitation of cancer therapy. Incretin-based therapies are established cardiometabolic agents with pleiotropic cardiovascular effects; however,...
Cardiac regeneration and repair: the emerging mechanisms and therapeutic approaches.
Myocardial infarction, characterized by irreversible cardiomyocyte loss, progressive cardiac fibrosis and subsequent deteriorated heart function, constitute an intractable global health burden. Promot...
Sterol biosynthesis, brain development, and disease.
Cholesterol biosynthesis is indispensable for CNS development and function. The developing brain relies almost entirely on intrinsic sterol synthesis to support membrane biogenesis, axonal outgrowth, ...
Associations Between Welding-Related Metals and Atherosclerotic Cardiovascular Disease Risk in Male Welders: The Mediating Role of Accelerated Biological Aging.
The impact of metals on atherosclerotic cardiovascular disease (ASCVD) risk in workers occupationally exposed to welding fume remains unclear. We aimed to assess the associations between welding-relat...
Ironing Out the Details: Advancing Diagnosis and Treatment of Iron Deficiency in Patients with Heart Failure with Preserved Ejection Fraction - A Narrative Review.
Iron deficiency (ID) is a highly prevalent and clinically significant comorbidity in heart failure with preserved ejection fraction (HFpEF), affecting 40-60% of patients. Independent of anemia, ID is ...
Beyond clinical congestion in acute heart failure: integrating lung ultrasound, venous doppler, and echocardiographic hemodynamics for imaging-guided decongestion.
Acute heart failure (AHF) is a major cause of hospitalisation worldwide and remains associated with substantial early rehospitalisation and short-term mortality. Accurate assessment of congestion rema...
Epigenetic Control of Mammalian Cardiomyocyte Proliferation.
PURPOSE OF REVIEW: Postnatal shutdown of the mammalian cardiomyocyte cell cycle underpins limited regenerative capacity of the adult heart. An epigenetic programme regulates a switch at birth from a p...
miR-187-3p as a Biomarker for Ischemic Stroke and the Therapeutic Target for Atherosclerosis via LOX-1 Inhibition.
As the primary receptor of oxidized low-density lipoprotein (ox-LDL), LOX-1 is a putative therapeutic target for atherosclerotic disorders including ischemic stroke (IS), whereas the regulatory mechan...
Direct oral anticoagulants and warfarin in atrial fibrillation patients with cancer by anticoagulation quality.
BACKGROUND: Atrial fibrillation (AF) patients with cancer are frequently treated with vitamin K antagonists (VKAs). Direct oral anticoagulants (DOACs) benefit according to VKA quality has not been inv...
m6A-Modified KLF11 Inhibits Macrophage Foam Cell Formation by Transcriptionally Suppressing ATP5B Expression in Atherosclerosis.
Macrophage foam cell formation is the mark of atherosclerosis (AS). Krüppel-like factor (KLF)11 prevented the development of AS in diabetic conditions. However, it is not clear whether KLF11 inhibits ...
SENP3 Deficiency Inhibits Atherosclerosis by Regulating TLR4/NF-κB and SOAT2.
SUMOylation plays critical roles in both initiation and development of atherosclerosis. SUMO-specific protease 3 (SENP3), a SUMO-specific protease that targets SUMO2/3 for deSUMOylation, is involved i...
Relationship of glymphatic dysfunction and frontothalamic structure with cognitive impairment in attention deficit hyperactivity disorder.
Cognitive deficits constitute a core feature of attention deficit hyperactivity disorder (ADHD), yet their underlying neurobiological mechanisms remain incompletely understood. This study investigates...
Echocardiography Assessment of Cardiac Function and Pulmonary Hypertension in Lambs.
Premature birth is strongly associated with cardiac dysfunction, including impaired ventricular function and altered cardiac structure, which can lead to progressive heart failure and other short- and...
Post-Marketing Nutrivigilance of Red Yeast Rice-Containing Food Supplements: Spontaneous Adverse Event Reports and Exposure-Based Reporting Rate Estimates.
Background and Objectives: Red yeast rice (RYR)-containing food supplements are widely used for mild-to-moderate hypercholesterolemia, but their post-marketing safety remains relevant. This study char...
BMI-Dependent Modulation of the Soluble RAGE-Sirtuin-1 Axis by Coffee Type in Coronary Artery Disease.
BACKGROUND: Coffee contains bioactive compounds associated with cardiometabolic benefits, which modulate metabolic pathways of Sirtuin-1. The AGEs-RAGE axis promotes Sirtuin-1 degradation, but soluble...
Red Cell Distribution Width-Standard Deviation and the Severity of In-Stent Restenosis: Associations with Angiographic Stenosis Burden and Mehran Classification.
Background and Objectives: Red cell distribution width-standard deviation (RDW-SD) has been associated with systemic inflammation and adverse cardiovascular outcomes, but its relationship with the ang...