The association of obstructive sleep apnea with the frailty index in individuals stratified by cardiovascular-kidney-metabolic syndrome stages.

Association between obstructive sleep apnea (OSA) and frailty progression across various stages of cardiovascular-kidney-metabolic (CKM) syndrome. Data processing and analysis were performed using R v...

Mortality trends and disparities for coexisting heart failure and thyroid disease: A retrospective analysis of deaths in the United States from 1999 to 2023.

Heart failure (HF) and thyroid disease (TD) are 2 common and interacting chronic diseases, and the combined impact of comorbidity on mortality has not been fully studied. This study aims to analyze mo...

Trends in heart failure mortality among patients with rheumatoid arthritis in the United States (1999-2020): A nationwide cross-sectional analysis of the CDC WONDER database.

Rheumatoid Arthritis (RA) is a known risk factor for heart failure (HF) due to its chronic autoimmune-mediated inflammation. However, data on trends of Rheumatoid arthritis associated HF mortality in ...

Frailty index and tolerability of SGLT2 inhibitors in elderly (≥75 years) patients with heart failure.

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are cornerstone therapies for heart failure (HF), but data on tolerability in frail elderly patients (≥75 years) remain limited. This study investiga...

Cardiac remodeling in CKD: Diagnostic utility of circulating fibroblast growth factor‑23.

Left ventricular hypertrophy (LVH) is a hallmark of uremic cardiomyopathy and a strong predictor of adverse outcomes in chronic kidney disease (CKD). Conventional biomarkers often fail to capture the ...

Heart recipient outcomes following transplantation of donor hearts with impaired versus normal function: a study protocol for IMPROVED Heart, a prospective multicentre observational study.

BACKGROUND: Cardiac transplantation remains the most effective treatment for patients with end-stage heart failure, but its use is limited by donor organ shortage. Expanding donor acceptance criteria ...

Q&A with Carolyn S.P. Lam.

Professor Carolyn S.P. Lam is a senior consultant cardiologist at the National Heart Centre Singapore, where she founded Singapore's first women's heart clinic, and a tenured full professor at Duke-NU...

Efficacy and safety of apixaban versus warfarin in new-onset atrial fibrillation post coronary artery bypass grafting: A retrospective cohort study.

New-onset postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery, especially coronary artery bypass grafting (CABG), affecting up to 40% of patients, and is associ...

Effectiveness and safety of left atrial appendage electrical isolation in managing persistent atrial fibrillation: an updated meta-analysis of 3425 patients.

BACKGROUND AND AIM: Atrial fibrillation (AF) is a substantial public health disorder associated with heightened morbidity and mortality. Pulmonary vein isolation (PVI) has limited efficacy in persiste...

Endothelial injury biomarker EASIX predicts mortality risk in adults with chronic obstructive pulmonary disease: A retrospective cohort study.

Endothelial dysfunction has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). This study aimed to examine the utility of the Endothelial Activation a...

Cross-sectional association between relative fat mass and abdominal aortic calcification among US adults: The NHANES 2013 to 2014.

Abdominal aortic calcification (AAC) serves as a reliable predictor of future cardiovascular incidents. This study investigated the association between relative fat mass (RFM) and AAC in US adults. A ...

Interaction of Listeria monocytogenes with the human choroid plexus endothelium in vitro: impact on invasion of the epithelium.

In the central nervous system (CNS), the highly vascularized choroid plexus (CP) produces the cerebrospinal fluid (CSF) and also acts as a blood-CSF barrier (BCSFB). Due to its location in the ventric...

Cardiomyopathy in glycogen storage diseases: diagnosis, prognosis, and advanced management.

Glycogen storage diseases (GSDs) are a heterogeneous group of rare and often under-recognized causes of inherited cardiomyopathy characterized by pathological glycogen or autophagic vacuole accumulati...

A multivariate electrocardiographic predictive model for left ventricular hypertrophy in children with primary hypertension.

UNLABELLED: Current electrocardiographic (ECG) criteria are of low diagnostic value compared with echocardiography (ECHO) for LVH, establishing a more effective ECG predictive model is required. The r...

Precision Medicine for Anticoagulation Strategies in the Cath Lab: Part 1.

PURPOSE OF REVIEW: Intraprocedural anticoagulation in the cardiac catheterization laboratory is essential to prevent thrombus formation on catheters, guidewires, and stents while minimizing bleeding r...

Heart failure with mildly reduced ejection fraction (HFmrEF): where are we now?

Heart failure (HF) with mildly reduced ejection fraction (HFmrEF), recently also termed HF with mid-range EF, describes a patient with a left ventricular ejection fraction of 40-49% (5). This classifi...

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart.

Trametinib (Trm) is a highly selective mitogen-activated protein kinase kinase (MEK) inhibitor that potently and persistently abrogates extracellular signal-regulated kinase 1/2 activation. Trm initia...

The Evolving Role of Coronary Artery Imaging in Assessing Cardiovascular Risk from Lipoprotein(a).

PURPOSE OF REVIEW: Summarize current literature on the use of coronary artery imaging modalities in examining the atherosclerotic and arterial inflammatory manifestations of elevated lipoprotein(a) [L...

Nicotinamide mononucleotide ameliorates high glucose/high fat-induced cardiomyocyte metabolic dysfunction through SIRT1-mediated CPT1A stabilization.

OBJECTIVE: To investigate the mechanism of nicotinamide mononucleotide (NMN) in ameliorating high glucose/high fat (HG/HF)-induced metabolic dysfunction in diabetic cardiomyopathy (DCM) through SIRT1-...

A conceptual review of intracellular pH as a regulator of the adenosine-L-arginine-nitric oxide (ALANO) axis in human fetoplacental endothelial dysfunction in gestational diabetes mellitus.

This conceptual review provides a synthesising narrative of the interdependent regulation of intracellular pH (pHi), nitric oxide (NO), and adenosine-the pHi-NO-adenosine triad-in fetoplacental endoth...