PD-1/PD-L1 inhibitor induces systemic inflammation and alters cardiac lipid metabolism in C57BL/6 J mice.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, and their side effects, such as cardiotoxicity, have become critical complications. Herein, we explored the potential mechanism ...
Dimethyl itaconate preserves cardiac function and reduces remodeling via anti-fibrotic actions in rats.
BACKGROUND: Cardiac hypertrophy is a pathological condition associated with the enlargement of the heart muscle and serves as a risk factor for heart failure. Itaconic acid is a metabolite produced by...
The middle hepatic artery: prevalence and origin patterns of a distinct segment 4 artery.
BACKGROUND: The middle hepatic artery (MHA) is commonly used to describe the artery supplying segment 4 of the liver. Because preservation of segment 4 inflow is important in hepatobiliary surgery, es...
Preliminary Application of Antihypertensive Gene Detection in the Treatment of Hypertension.
BACKGROUND Hypertension management is often suboptimal due to interindividual variability in drug response. Pharmacogenomics testing may guide personalized therapy by identifying genetic polymorphisms...
Association between intradialytic blood pressure and left ventricular mass index in end-stage renal disease.
AIM: To evaluate whether single and two-month average intradialytic blood pressure (BP) measurements, including systolic blood pressure (SBP) and diastolic blood pressure (DBP), are associated with le...
Nutraceuticals for the Management of Cardiovascular Health: A Mechanistic and Evidence-Based Review Focusing on Atherosclerosis and Hypertension.
Cardiovascular diseases (CVDs) constitute one of the leading global health burdens, accounting for nearly 50% of all deaths worldwide. Rapid urbanization, lifestyle transitions, psychosocial stress, s...
Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index.
BACKGROUND: Pectus excavatum (PEX) is the most common congenital chest wall deformity and may result in cardiac compression and arrhythmias. The relationship between structural severity and exercise-i...
Incidence and risk factors for permanent pacemaker implantation following aortic root surgery.
BACKGROUND: Permanent pacemaker implantation (PPI) remains a serious complication following aortic root replacement (ARR) and valve-sparing root replacement (VSRR). This is due to the proximity of the...
Sex-disaggregated data in hypertrophic cardiomyopathy: a targeted literature review, meta-analysis and primary cohort study.
OBJECTIVE: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy characterised by pathological left ventricular hypertrophy and categorised into obstructive and non-obstructive...
Chronic ketamine use associated with progressive multisystem organ dysfunction.
A man in his 30s developed progressive multisystem organ dysfunction following 15 years of heavy recreational ketamine use. Complications included ketamine cystitis, cholangiopathy, obstructive uropat...
Colchicine enhances macrophage cholesterol efflux by targeting DTL-mediated ubiquitination and degradation of ABCA1.
OBJECTIVE: This study aims to elucidate the potential pharmacological mechanisms by which colchicine confers clinical benefits in patients with atherosclerotic cardiovascular disease, focusing on its ...
Association of miR-133a With Microalbuminuria in Patients With Resistant Arterial Hypertension and Chronic Kidney Disease.
BACKGROUND MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and have emerged as potential biomarkers of cardiovascular and renal diseases. Resistant arterial hyperte...
STIM1-dependent treg dysfunction promotes cardiometabolic HFpEF: insights from patients and animal studies.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) arises from chronic cardiometabolic and vascular stress and is increasingly recognized as an inflammatory syndrome with immune dysreg...
Prognostic value of baseline and longitudinal changes in exercise capacity and quality of life in the HF-Wii Swedish population.
UNLABELLED: This study aimed to explore whether baseline values and 12-month change in the 6-Minute Walk Distance (6MWD) and the physical scale of the Minnesota Living with Heart Failure Questionnaire...
Molecular profiling of the single-cell proteome via gel electrophoresis and 3D single-molecule imaging.
Recent advances in shotgun proteomics and immunoassays have yielded powerful single-cell proteomics technologies. However, current methods lack the sensitivity required to comprehensively quantify pro...
Mast Cells in the Developing Brain.
Brain development requires the coordination of numerous cell types including neurons, glia, and immune cells. Mast cells (MCs) are tissue-resident innate immune cells canonically known for their role ...
Coronary Artery Disease in Women: Sex-Specific Pathophysiology, Risk Factors, Clinical Presentation and Management.
Cardiovascular disease remains the leading cause of mortality among women worldwide, yet coronary syndromes in women continue to be under-recognized and insufficiently represented in clinical research...
The Real-World Use of Guideline-Directed Medical Therapy in Patients with Heart Failure with Reduced Ejection Fraction Newly Initiated on Dapagliflozin: An EVOLUTION-HF CEE-BA Study (Results from the Baltic Cohort).
Background and Objectives: Guideline-directed medical therapy (GDMT) remains a challenge due to its low rates worldwide. Adherence to GDMT in patients with heart failure (HF) and reduced ejection frac...
Assessing Murine Aortic Intrinsic Stiffness Using Pin Myography: A Translational Framework For Interrogating The Influence of the Circulating Milieu.
Aortic stiffening is an independent risk factor for cardiovascular disease and other chronic conditions, including cognitive decline, kidney dysfunction, vision impairment, and reduced glucose-insulin...
Ultra-Delayed Intracardiac Cement Embolism After Percutaneous Vertebroplasty: A Case Report and Review of Management Strategies.
Cardiac cement embolism is a rare but potentially life-threatening complication of percutaneous vertebroplasty, usually occurring during or shortly after the procedure. Delayed presentations remain po...