Jingling Granules alleviate atherosclerosis through activating autophagy and inhibiting human umbilical vein endothelial cells apoptosis.

Atherosclerosis (AS) remains a leading cause of cardiovascular morbidity worldwide. Strategies that promote autophagy and limit apoptosis hold therapeutic promise. Jingling Granules (JLG), a clinicall...

Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.

BACKGROUND: Obesity is widely recognized as an aggravating risk factor for atherosclerosis (AS), yet the effects of obesity on AS-associated microbiome dysbiosis are not sufficiently characterized. Th...

Deficiency of the aryl hydrocarbon receptor in kidney epithelial cells does not influence the development of atherosclerosis.

The aryl hydrocarbon receptor (AHR) is recognised as an important mediator of inflammatory processes, including those in kidney health. Patients suffering from kidney diseases have an increased risk o...

The Redox-Inflammation Axis in Atherosclerosis and Ischemic Stroke: Mechanisms, Biomarkers, and Translational Challenges.

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and are driven by the interplay between oxidative stress and chronic inflammation. Although these processes have been ext...

Linguistic and Clinical Validation of the Polish Version of the Walking Impairment Questionnaire.

BACKGROUND: Intermittent claudication is one of the most common symptoms of peripheral arterial disease. The Walking Impairment Questionnaire (WIQ) is frequently used to assess patients suffering from...

Inflammation and Immune Mediators in the Context of Atherosclerotic Cardiovascular Disease and Percutaneous Coronary Intervention: Implications for Therapeutics.

Atherosclerotic cardiovascular disease (CVD) remains a leading cause of worldwide morbidity and mortality, despite well-established/effective pharmacological therapies. A substantial component of the ...

Rethinking Lipid Burden and the Role of Non-LDL Biomarkers in Stroke Risk Stratification.

PURPOSE OF REVIEW: This article reviews the existing literature on non-LDL biomarkers in atherosclerotic cardiovascular disease (ACSVD), atherogenesis, and ischemic stroke risk, including a discussion...

Protective Effect of Natural Phenolic Acids, Rosmarinic Acid and Salvianolic Acid, Against Diabetic Atherosclerosis.

Cardiovascular disease (CVDs) and atherosclerosis remain a major causes of morbidity and mortality worldwide. Endothelial dysfunction is a central driver of atherosclerosis, which is significantly acc...

Relationship Between Dietary Inflammatory Index With Biochemical Markers and Atherogenic Risk in Patients With Atherosclerotic Heart Disease.

AIMS/BACKGROUND: The relationship between cardiovascular disease and the inflammatory potential of diet has been recently reported. This study aimed to investigate the relationship between a pro-infla...

[The dual effects and therapeutic prospects of ketone bodies in atherosclerosis].

动脉粥样硬化是一种因代谢紊乱引发的慢性炎症性疾病，涉及高血压、血脂紊乱、糖尿病等多个因素。传统观念认为过高的酮体会加速动脉粥样硬化的进程，但近期研究揭示了酮体的复杂作用。在动脉粥样硬化的发展过程中，酮体一方面可以为受损血管提供能量底物，另一方面在特定条件下发挥抗炎和抗氧化作用，抑制动脉粥样硬化的进展。该综述将深入分析酮体在动脉粥样硬化中的双重影响及其潜在机制，以期为动脉粥样硬化的临床治疗和疾病管理...

Bioinspired porous metal-amino acid nanozymes enable multi-pathway treatment of atherosclerosis through anti-oxidation and pro-efferocytosis.

Atherosclerosis is characterized by chronic inflammation, persistent oxidative stress, intimal lipid accumulation, and impaired efferocytosis within plaques. Here, we develop a copper-based porous nan...

Effect of pictorial-based information about atherosclerosis on adherence to lifestyle recommendations: results from the VIPVIZA randomised controlled trial.

AIM: Low adherence to a healthy lifestyle constitutes a major barrier to effective prevention of cardiovascular disease. We aimed to investigate the effect of pictorial-based information about subclin...

Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence.

Periodontitis and cardiovascular disease share inflammatory, immune, endothelial, oxidative, and lipid-related pathways. Although sex-related differences are well established for many cardiovascular b...

Integrated Bioinformatics and Machine Learning Analysis Identifies Inflammation-Related Biomarkers and Immune Infiltration Patterns in Atherosclerosis.

Background: Atherosclerosis (AS) is a chronic inflammatory vascular disease lacking reliable biomarkers for early diagnosis and risk stratification. This study aimed to identify hub genes with diagnos...

Association of Pitavastatin Versus Atorvastatin Therapy With Glycaemic Control and New-Onset Diabetes in Older Adults With Atherosclerotic Cardiovascular Disease.

AIMS/BACKGROUND: Statins are first-line therapy for atherosclerotic cardiovascular disease (ASCVD), but their differential effects on glucose metabolism, particularly in the elderly, remain a clinical...

Incretin-Based Therapies, Obesity-Associated Inflammation, and Atherosclerotic Cardiovascular Risk.

Cardiovascular disease remains a leading cause of mortality despite major advances in lipid lowering and risk-factor control, highlighting the importance of residual cardiovascular risk. Inflammation ...

Triglyceride-Rich Lipoproteins and ASCVD: Evidence for Causality and Challenges in Therapeutic Translation.

PURPOSE OF REVIEW: This review summarizes current evidence linking triglyceride-rich lipoproteins (TRLs) to atherosclerotic cardiovascular disease (ASCVD) with emphasis on challenges in translating th...

LAMB2 p.E991K Mutation-Mediated Atherosclerosis in Rabbit.

Background: Atherosclerosis is a major pathological basis of cardiovascular disease and is influenced by both genetic and environmental factors. Although genome-wide association studies have identifie...

Unveiling perceptions: a small-scale qualitative case study related to patient experience of inpatient screening for familial hypercholesterolemia.

BACKGROUND: Familial hypercholesterolaemia (FH) is a hereditary, genetic disorder disrupting the metabolism of low-density cholesterol from birth. Untreated, 50% of men develop atherosclerotic cardiov...

Spatiotemporal orchestration of macrophage heterogeneity by cell adhesion molecules.

Monocyte-derived macrophages (mo-macs) are central regulators of innate immunity and are essential for maintaining physiological homeostasis and host defense. Their functional efficacy relies on preci...