A Multi-Stage Drop-the-Loser Design With Superiority Boundaries.

Multi-arm multi-stage (MAMS) trials have gained popularity, due to their improved efficiency in evaluating multiple treatments. A traditional MAMS trial often decreases the expected sample size of the...

Radiation dose optimization in coronary CT angiography clinical application of absolute phase gating in patients with atrial fibrillation.

BACKGROUND: Atrial fibrillation (AF) poses significant challenges for coronary CT angiography (CCTA) due to R-R interval variability, often necessitating high radiation dose protocols. Absolute phase ...

The Cardiac Safety of High-Dose Propranolol Used to Treat Severe Behaviors With Autism Spectrum Disorders.

BACKGROUND: Aggression and self-abusive behaviors are serious problems in the developmentally disabled. Several medications have shown efficacy, but many individuals remain inadequately treated or int...

Simulation-Based Training for New-Onset Symptomatic Rapid Atrial Fibrillation Among Prehospital Health Care Providers.

OBJECTIVE: Atrial fibrillation is the most common cardiac arrhythmia in clinical practice making proficient diagnosis and treatment vital to patient outcomes. The increased incidence of new-onset symp...

High-Frequency Low-Tidal Volume Ventilation and Catheter-Tissue Interaction During Pediatric Radiofrequency Ablation: A Prospective Observational Study.

OBJECTIVES: To evaluate the association between ventilation strategy and catheter-tissue interaction, lesion characteristics, and procedural metrics during pediatric supraventricular tachycardia ablat...

Atrial Tachycardia Utilizing Bachmann's Bundle as an Epicardial Bypass: A Case Suggestive of a Dual-Loop Mechanism.

A 70-year-old man with a history of prior ablation for atrial fibrillation presented with atrial tachycardia (AT). Electrophysiological studies revealed roof-dependent and localized-reentrant ATs. Dur...

Glucagon-like peptide-1 receptor agonists versus sodium-glucose cotransporter-2 inhibitors in adults with type 2 diabetes and atrial fibrillation: a multicenter comparative effectiveness cohort study of cardiovascular and arrhythmic outcomes.

AIMS: To compare glucagon-like peptide-1 receptor agonists (GLP-1RA) with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) for cardiovascular, atrial fibrillation (AF) disease course, and safety ou...

Cardiac involvement in Behçet's syndrome: findings from a clinically driven cardiological evaluation.

OBJECTIVES: To characterize prevalence, patterns, and clinical correlates of cardiac involvement in a cohort of patients with Behçet's syndrome (BS) undergoing clinically driven cardiological assessme...

Prospective evaluation of atrial fibrillation-related stroke patients in rehabilitation programme (PEARL), clinical study for the 'Health virtual twins for the personalised management of stroke related to atrial fibrillation (TARGET)' project: a protocol for a prospective cohort analysis.

INTRODUCTION: Rehabilitation is recognised as a cornerstone of recovery in the stroke care pathway, and the intensity of therapy is closely related to functional recovery. However, longitudinal studie...

Deep Neural Networks for Automatic Atrial Fibrillation Detection Using Long-Term Ambulatory Electrocardiography: Retrospective Diagnostic Accuracy Study.

BACKGROUND: Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, affects 2% to 4% of the global adult population and is associated with an increased risk of stroke. Early diagnosis of AF a...

Antithrombotic Management in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation.

PURPOSE OF REVIEW: Atrial fibrillation (AF) and/or the need for oral anticoagulation (OAC) frequently coexist with stable chronic coronary syndrome (CCS). In this population, clinicians must carefully...

Berberine Stabilizes the Arrhythmogenic Substrate in Obese Rats by Klotho-Mediated Attenuation of Oxidative Stress and Inflammation.

Obesity increases susceptibility to ventricular arrhythmias due to an arrhythmogenic substrate by promoting oxidative stress and inflammation-driven cardiac remodeling. Klotho, an anti-aging protein t...

Research on identification of key genes and immune-metabolic mechanisms in atrial fibrillation through integrated multi-cohort transcriptomic analysis and machine learning.

This study aimed to integrate multiple datasets for the identification of atrial fibrillation (AF)-related differentially expressed genes (DEGs), analyze their underlying mechanisms through functional...

Clinical characteristics associated with ischaemic stroke and transient ischaemic attack among non-anticoagulated patients with atrial fibrillation.

AIM: We aimed to examine clinical characteristics associated with ischaemic stroke (IS) or transient ischaemic attack (TIA) among non-anticoagulated patients with atrial fibrillation (AF). METHODS: We...

[Multi-lead electrocardiogram atrial fibrillation detection algorithm based on multi-scale patch-based attention].

Aiming at the deficiencies of insufficient cross-domain generalization and poor rhythm sensitivity in atrial fibrillation (AF) detection from multi-lead electrocardiogram (ECG) signals, this paper pro...

Cross-domain transfer learning strategy enhances interpretability of deep learning model explanations.

Clinical decision-making increasingly relies on deep neural networks (DNNs), yet their deployment in practice requires transparent and interpretable predictions. Explainable artificial intelligence (x...

Arrhythmic risk stratification in psoriatic arthritis: a retrospective, electrogram-based comparative analysis.

BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease that is associated with cardiovascular comorbidities, particularly with an increased risk of arrhythmias. Despite the e...

[Clinical characteristics, antithrombotic therapy, and prognosis of new-onset atrial fibrillation in the acute phase of ST-segment elevation myocardial infarction].

Objective: To investigate the clinical characteristics and antithrombotic treatment strategies in patients with acute ST-segment elevation myocardial infarction (STEMI) who develop new-onset atrial fi...

Impact of Ca(V)1.3 L-Type Calcium Channels on Arrhythmogenesis in Cancer.

Cardiovascular disease and cancer remain the leading causes of death worldwide. Although numerous cancer therapies have improved survival rates, they also increase the risk of cardiomyopathy, heart fa...

ECG Signal Compression and Reconstruction Based on CNN-LSTM-Attention Model.

The high prevalence of cardiovascular diseases and the extensive application wearable electrocardiogram (ECG) devices for long-term monitoring have posed significant challenges for the transmission, s...