[Proteomic and metabolomic profiling of the rat model of myocardial ischemia-reperfusion injury treated with electroacupuncture].

This study aims to explore the protective effect of electroacupuncture (EA) on myocardial ischemia-reperfusion injury (MIRI) and decipher the molecular mechanism. Forty male SD rats were randomly allo...

Two Faces of the Right Ventricle in Fabry Cardiomyopathy: Septal-Coupled and Atrial-Coupled Strain Patterns and Their Differential Associations with Enzyme Replacement Therapy.

Right ventricular global longitudinal strain (RVGLS) and right ventricular free-wall longitudinal strain (RVFWLS) are both used to assess right ventricular involvement, but they include different myoc...

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy.

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state a...

[Disease burden and risk factors of myocarditis among children and adolescents aged 0-19 years in China from 1990 to 2021 and projection of future disease burden trends].

OBJECTIVES: Based on data from the Global Burden of Disease Study (GBD) 2021, this study aims to analyze trends in myocarditis among children and adolescents aged 0-19 years in China from 1990 to 2021...

[Screening and genetic variation analysis of fatty acid oxidation disorder in neonates in Qingdao City].

OBJECTIVES: To investigate the incidence, genetic mutation characteristics, and prognosis of fatty acid oxidation disorder (FAOD) in neonates in Qingdao. METHODS: Clinical data of neonates diagnosed w...

Evaluating the reliability and quality of viral myocarditis educational content on TikTok and Bilibili: A cross-sectional content analysis.

Viral myocarditis (VM) affects over 1 million people yearly worldwide and may trigger arrhythmia, heart failure, or sudden death, bringing heavy clinical and economic burdens. TikTok and Bilibili are ...

A Rare Case of Takotsubo Cardiomyopathy Recurrence With Alternate Reverse Phenotypes.

BACKGROUND Takotsubo cardiomyopathy (TCM) is a stress-induced cardiomyopathy characterized by transient left ventricular systolic dysfunction and reversible regional wall-motion abnormalities extendin...

Integrated Bioinformatics and Experimental Validation of Post-Translational Modification-Related Biomarkers in Myocardial Ischemia-Reperfusion Injury.

Myocardial ischemia-reperfusion injury (MIRI) lacks fully established post-translational modification (PTM)-associated biomarkers. This study aimed to identify and validate PTM-related MIRI biomarkers...

Reperfusion Injury and Infarct Size: Why Translation has Been Difficult, and How We Move Forward.

PURPOSE OF REVIEW: To evaluate the reasons underlying the translational failure of cardioprotection in reperfused ST-elevation myocardial infarction (STEMI) and propose a framework for designing futur...

Comparative efficacy of pharmacological therapies in non-obstructive hypertrophic cardiomyopathy: a frequentist network meta-analysis.

BACKGROUND: Management of symptomatic non-obstructive hypertrophic cardiomyopathy (HCM) remains challenging, and evidence comparing pharmacological therapies is limited. While several randomized contr...

Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives.

Myocardial ischemia-reperfusion injury (MIRI) is an inevitable pathological complication following reperfusion therapy for acute myocardial infarction. Massive reactive oxygen species burst, mitochond...

Nuevas perspectivas en la cardiopatía chagásica: genética, resonancia magnética y posibles alternativas terapéuticas. Una revisión narrativa.

Chagasic cardiomyopathy is the chronic manifestation of American trypanosomiasis. In endemic regions of Peru, delayed diagnosis remains a major public health concern. This review analyzes recent evide...

The role of IL-6 in hypertrophic and dilated cardiomyopathy: clinical and therapeutic implications.

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are genetically heterogeneous myocardial disorders in which disease progression is influenced by secondary modifiers beyond structura...

[A novel TPM1 variant causing Dilated cardiomyopathy in a child: A case report and literature review].

OBJECTIVE: To explore the clinical manifestations and characteristics of TPM1 gene variants causing Dilated cardiomyopathy (DCM) in children. METHODS: This study focused on a pediatric patient diagnos...

Iron overload cardiomyopathy.

Iron overload cardiomyopathy (IOC) remains an important cause of morbidity and mortality in patients with hereditary haemochromatosis and transfusion-dependent conditions such as haemoglobinopathies. ...

Beyond the Pump: Unravelling Immunometabolic Crosstalk and Organelle Dynamics in Sepsis-Induced Cardiomyopathy.

Sepsis-induced cardiomyopathy (SICM) has traditionally been viewed as pump-centered contractile failure, but this paradigm fails to explain the clinical spectrum and recovery patterns. This review pre...

Exploring the role of CaMKII in exercise-induced cardioprotection.

Regular physical exercise can induce a multifaceted cardioprotective phenotype characterized by improved Ca2⁺ handling, mitochondrial resilience, redox buffering, autonomic regulation, and resistance ...

A Novel SLC25A4 Variant Causing Mitochondrial Dysfunction, Myopathy and Cardiomyopathy: A Functional and Molecular Characterization.

SLC25A4, solute carrier family 25 member 4, gene is a member of the mitochondrial carrier subfamily within the solute carrier protein family. Pathogenic variants in SLC25A4 are associated with a spect...

Hypertrophic cardiomyopathy-linked Tnnc1 variants are associated with distinct myopathic changes in slow skeletal muscle of mice.

Inherited hypertrophic cardiomyopathy (HCM) is considered a disease of the cardiac sarcomere and caused by pathogenic variants present in genes that encode sarcomeric proteins. The human TNNC1 gene is...

Disproportionality analysis of drug-induced myocarditis: Insights from the Food and Drug Administration Adverse Event Reporting System database.

ObjectiveDrug-induced myocarditis is a rare but serious adverse events that may have a significant impact on patient prognosis. To identify signals of disproportionate reporting associated with drug-i...