Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis.

BACKGROUND: Diabetic cardiomyopathy (DCM) is a diabetes-related myocardial disorder causing fibrosis, hypertrophy, and progressive diastolic and systolic dysfunction. This study aims to explore how me...

Efficacy of Steroid Therapy in Preventing Adverse Clinical Outcomes in Patients with Fulminant Myocarditis Requiring Mechanical Circulatory Support.

There is limited data about the efficacy of steroid therapy in preventing adverse clinical outcomes in fulminant myocarditis requiring mechanical circulatory support (MCS). This study aimed to evaluat...

Clinical Impact of Cardiac Arrest in Patients with Fulminant Myocarditis Requiring Veno-Arterial Extracorporeal Membrane Oxygenation.

Fulminant myocarditis (FM) is characterized by rapid hemodynamic deterioration and is often accompanied by cardiac arrest (CA). Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is frequentl...

CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease.

Chagas disease, caused by Trypanosoma cruzi, is the major cause of infectious cardiopathology worldwide. Although cytotoxic CD4 T-cells (CD4 CTLs) have recently been recognized as crucial effectors in...

Modeling Hypertrophic Cardiomyopathy-Related MYH7 Variants: Insights into Structural Changes and Cardiovascular Drug-Binding Affinities.

Mutations in the MYH7 gene, which encodes β-myosin heavy chain (β-MHC), are a significant cause of hypertrophic cardiomyopathy (HCM). These variants may lead to variable clinical outcomes, thereby inf...

Integrating ECG and echocardiography to identify early-stage transthyretin amyloid cardiomyopathy.

Current diagnostic criteria for transthyretin amyloid (ATTR) cardiomyopathy (ATTR-CM) emphasize increased left ventricular (LV) wall thickness, potentially delaying recognition of early myocardial inv...

Adenovirus-Associated Viral Vector Based Gene Replacement Therapy for the treatment of Arrhythmogenic Cardiomyopathy.

Arrhythmogenic Cardiomyopathy (ACM) is a primary disorder of the myocardium characterized by a high propension for ventricular arrhythmias (VAs) and sudden cardiac death (SCD). Several genes have been...

Long-Term Durability of Acoramidis Efficacy in Transthyretin Amyloid Cardiomyopathy: Open-Label Extension of the ATTRibute-CM Randomized Clinical Trial.

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive disorder caused by destabilization of serum transthyretin (sTTR). Acoramidis, an approved therapy that achieves near-complete (≥90%) sTT...

RBM20 Truncating Variants and Human Cardiomyopathy.

Genetic diagnosis has become increasingly important to guide clinical decision-making for patients with dilated cardiomyopathy (DCM). Pathogenic or likely pathogenic (P/LP) missense variants in the ge...

Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy.

Transthyretin amyloidosis with cardiomyopathy is a progressive, fatal disease characterized by deposition of extracellular misfolded transthyretin (TTR) in the myocardium. Eplontersen is an N-acetylga...