Mechanisms and Intervention Strategies for Heat Stroke-Associated Myocardial Dysfunction: A Narrative Review.
INTRODUCTION: Heatstroke is a life-threatening condition defined by a core body temperature exceeding 40° C and central nervous system dysfunction. Its onset is potentiated by high heat and humidity, ...
Artificial Intelligence-Enhanced Electrocardiography Analysis for Diagnosing Chagas Disease.
BACKGROUND: Chagas disease affects millions worldwide and remains a leading cause of cardiomyopathy in Latin America. Early diagnosis remains challenging in endemic regions. Artificial intelligence (A...
Twenty-Year Follow-up After Combined Heart and Kidney Transplant: A Case Report.
Combined heart and kidney transplant is a rare but valuable treatment option for selected patients with end -stage cardiac and renal failure. We present the long -term outcome of a 27 -year -old man w...
Distinct Echocardiographic Phenotypes in Primary vs. Secondary Iron Overload Cardiomyopathy: A Pilot Study on Myocardial Work Indices.
Background: Iron overload cardiomyopathy (IOC) is a major determinant of outcomes in hemochromatosis, and conventional echocardiography may miss early myocardial toxicity. Comparative data on primary ...
Clinical Presentation, Etiology, and Outcomes of HIV-Associated Cardiomyopathy: A Systematic Review of Published Case Reports.
HIV-associated cardiomyopathy is a significant cause of morbidity and mortality among people living with HIV, contributing to heart failure, arrhythmia, and sudden cardiac death. Despite its clinical ...
[Cardiac Amyloidosis Registry in Santiago, Chile (RAMICAR): Three-Year Follow-Up Results].
UNLABELLED: Cardiac amyloidosis (CA) is characterized by extracellular protein deposition, generating ventricular hypertrophy, heart failure and arrhythmias. The main proteins involved are light chain...
Arrhythmogenic right ventricular cardiomyopathy - a disease that ends athletic careers.
Arrhythmogenic right ventricular cardiomyopathy, commonly detected between the second and fifth decades of life, is caused by mutations that result in the dysfunction of the junctions between cardiomy...
2周时间限制饮食对有心肌梗死病史患者先天免疫和全身炎症的影响：一项随机对照交叉研究
Preclinical evidence suggests that time-restricted eating (TRE) exerts beneficial metabolic and cardiovascular effects by ameliorating inflammation and modulating immune cell function. However, the ef...
Analysis of the value of stress echocardiography in latent left ventricular outflow tract obstruction in non-hypertrophic cardiomyopathy.
The accurate diagnosis of latent left ventricular outflow tract obstruction (LVOTO) in non-hypertrophic cardiomyopathy (NHCM) is crucial for treatment selection. This study evaluates the diagnostic va...
Stress-induced cardiomyopathy in the ICU.
Stress-induced cardiomyopathy (siCM), also known as Takotsubo syndrome, is an acute, transient, and typically reversible form of myocardial dysfunction. In the intensive care unit (ICU), siCM remains ...
When Hypertrophy Hides a Rarer Diagnosis: A Case of Danon Disease.
Danon disease (DD) is a rare X-linked dominant lysosomal storage disorder caused by mutations in the LAMP2 gene. It is typically characterized by a triad of intellectual disability, skeletal myopathy,...
High sensitivity for peripartum cardiomyopathy among large language models during differential diagnosis consideration.
BackgroundPeripartum cardiomyopathy (PPCM) is a rare, potentially life threatening condition with nonspecific heart failure symptoms, often leading to delayed diagnosis. Large language models (LLMs) m...
Migraine with visual aura, unilateral mydriasis and Takotsubo Syndrome. Random coincidence or common pathogenesis? The precarious balance of the autonomic nervous system and the complex relationship between brain and heart: a review of the literature.
OBJECTIVE: The recent examination of a woman who presented a migraine attack with visual aura and unilateral mydriasis, followed, a few days later, by an episode of Takotsubo Syndrome, prompted us to ...
Mitochondrial tRNA(Ser(AGY)) 12234A > G Mutation May Contribute to the Clinical Expression of Hypertrophic Cardiomyopathy-Associated tRNA(Ile) 4263A > G Mutation.
Mutations in mitochondrial tRNA (mt-tRNA) are found to be associated with hypertrophic cardiomyopathy (HCM), but their molecular mechanisms remain largely undetermined. In this study, we investigated ...
Immune checkpoint inhibitor-related myositis, myocarditis, and myasthenia gravis overlap syndrome: a systematic review and pooled analysis of individual cases.
BACKGROUND: Immune checkpoint inhibitor (ICI)-related overlap syndrome involving myositis, myocarditis, and myasthenia gravis (3M overlap syndrome) is rare but potentially fatal. Current evidence is d...
Prognostic value of the New York Heart Association classification for cardiovascular events and mortality in Chagas cardiomyopathy: a systematic review and meta-analysis with GRADE recommendations.
Chagas cardiomyopathy is associated with a higher risk of severe cardiovascular events and increased mortality. Among the factors associated with Chagas cardiomyopathy, impairment in functional capaci...
C-Myc Inhibition Using 10058-F4 Suppressed Ischemia Reperfusion Induced Cardiac Microvascular Endothelial Cell Pyroptosis through the Sam68/NF-κB Pathway.
Over the past few decades, most cardiac reperfusion research has focused on the pathogenesis of myocardial ischemia reperfusion injury (MIRI), while little attention has been paid to microvascular isc...
Dynamic LVOT Obstruction as a Cause of Hemodynamic Instability in Takotsubo Syndrome.
Takotsubo syndrome (TTS) frequently presents with chest pain, ST-segment elevation, and troponin elevation, closely mimicking acute coronary syndrome, and can be complicated by acute heart failure and...
Periapical abscess precipitating diabetic ketoacidosis and reversible sepsis-induced cardiomyopathy: a case report.
BACKGROUND: Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes mellitus, most commonly precipitated by infection. Patients with diabetes are at a significantly elevated r...
Integrated transcriptomic and metabolomic analysis reveals the regulatory role of itaconic acid in inflammatory infiltration during myocardial ischemia-reperfusion injury.
BACKGROUND: Inflammatory infiltration constitutes a fundamental pathophysiological mechanism in myocardial ischemia-reperfusion (IR) injury, characterized by its role in initiating tissue damage, ampl...