Spatiotemporal Analysis of Mortality from Cardiomyopathies in Brazil between 2001 and 2021.
BACKGROUND: Brazil presents regional variations in mortality from cardiomyopathies, influenced by demographic characteristics, socioeconomic inequalities, and differences in access to health services....
Early Detection of Acute Myocarditis in the Pediatric Population Using Clinically Accessible Data.
BACKGROUND: Early diagnosis of acute myocarditis (AMC) is crucial due to its rapid progression and high mortality rate. Initial symptoms such as fever, abdominal pain, and vomiting are nonspecific and...
Gut microbiota and serum metabolic profiles in patients with sepsis-induced cardiomyopathy and their association with the disease.
BACKGROUND: The pathogenesis of sepsis-induced cardiomyopathy (SIC) remains unclear, and the lack of effective treatment options results in high mortality rates. There may be interactions between gut ...
Pharmacovigilance Evaluation of Noninfectious Myocarditis and Pericarditis in Immune Checkpoint Inhibitor Recipients Using FAERS.
IntroductionImmune-related adverse events (irAEs) pose considerable challenges to the clinical application of immune-checkpoint inhibitors (ICIs). Noninfectious myocarditis/pericarditis is a class of ...
Cardiomyopathy in women with acromegaly: clinical characteristics and associated factors in a Colombian multicenter registry.
BACKGROUND: Acromegalic heart disease (AHD) is a common complication of acromegaly; however, evidence specifically focused on women in Latin America remains limited. OBJECTIVE: To characterize cardiom...
Expanding the Recessive Spectrum of Dilated Cardiomyopathy: RNA-Level Validation of a Homozygous CTNNA3 Splice-Site Variant.
CTNNA3 encodes αT-catenin, an intercalated disc (ICD) protein essential for cardiomyocyte coupling. Human omics studies have shown reduced CTNNA3 expression, ICD ultrastructural disruption, and dilate...
Asprosin Protects H9C2 Cells From Ferroptosis Following Hypoxia/Reoxygenation by Promoting Mitophagy.
BACKGROUND: Acute myocardial infarction is a leading cause of death globally. Percutaneous coronary intervention is the primary treatment to restore blood flow to the affected myocardium, but reperfus...
High-density lipoprotein cholesterol levels and prognosis in non-ischemic dilated cardiomyopathy.
BACKGROUND: Although low high-density lipoprotein cholesterol (HDL-C) is associated with poor outcomes in heart failure, its specific prognostic role in non-ischemic dilated cardiomyopathy (DCM) remai...
Cardioprotective effect of natural products on doxorubicin-induced cardiotoxicity and cardiac ischemia-reperfusion injury: A focus on ion channels modulation.
This article reviews the cardioprotective effects of natural products against doxorubicin (DOX)-induced cardiotoxicity and ischemia-reperfusion (I/R) injury, focusing on the modulation of ion channels...
Long-Chain Fatty Acid Oxidation Disorder Genes: A Comprehensive Genetic Database of LC-FAOD Variants, Genotypes, and Phenotypes.
Long-chain fatty acid oxidation disorders (LC-FAODs) are characterized by the inability to metabolize long-chain fatty acids. Serious clinical manifestations occur, including cardiomyopathy, hypoglyce...
Case Report: Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome with flow cytometric phenotyping before and after treatment in a patient with urothelial carcinoma.
Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS) is an uncommon immune-related adverse event (irAE) associated with the use of immune checkp...
Understanding immune checkpoint inhibitors-related myocarditis: Mechanisms and targeted therapeutic pathways.
Immune checkpoint inhibitor (ICI)-related myocarditis is a rare but often fatal adverse event that has gained increasing attention due to the widespread clinical use of ICIs. This review explores the ...
Awareness, attitudes, and barriers toward Transthyretin Amyloid Cardiomyopathy in Latin America: A questionnaire-based cross-sectional study.
BACKGROUND: Cardiac Amyloidosis (CA), specifically Transthyretin Amyloid Cardiomyopathy (ATTR-CM), is an under-recognized, progressive, and fatal disease. Comprehensive primary data describing awarene...
Successful rescue therapy with eculizumab for probable tislelizumab-related MMM overlap syndrome with dual positivity for anti-acetylcholine receptor and anti-titin antibodies: a case report and literature review.
BACKGROUND: While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, they can trigger diverse immune-related adverse events (irAEs). Among these, ICI-related myocarditis, myosit...
[Hypertrophic cardiomyopathy and implantable cardiodefibrillator: 25 years of follow up].
INTRODUCTION: The implantable cardiodefibrillator (ICD) is the best available treatment for patients with hypertrophic cardiomyopathy (HCM), survivors or at high risk of sudden cardiac death (SCD). Th...
Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but can induce immune-related myocarditis (ICI-MC), a rare yet life-threatening toxicity. This review elucidates the cellular and mo...
Development and validation of a nomogram model for predicting cardiac autonomic neuropathy in patients with diabetes.
BACKGROUND: Diabetic Cardiac Autonomic Neuropathy (DCAN), a critical yet frequently underdiagnosed microvascular complication, is associated with increased mortality. Standard cardiovascular autonomic...
Severe immune checkpoint inhibitor-induced 3M syndrome: a case report.
BACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved survival rates in various advanced cancers, including cervical cancer. However, they can induce a range of immune-related ad...
The immune-cardiovascular metabolic circuitry in myocardial ischemia-reperfusion injury: from metabolic signal release to spatiotemporal reprogramming.
Myocardial ischemia-reperfusion injury (MIRI) remains a major driver of infarct expansion, adverse remodeling, and poor outcomes after reperfusion therapy, yet mechanism-based treatments remain limite...
Myocarditis After mRNA Vaccination: A Metabolic-Innate Immune Cascade Centered on Lipid Nanoparticles.
mRNA vaccine-associated myocarditis is a rare but clinically important adverse event whose pathogenesis remains incompletely understood. Initial hypotheses focused primarily on the spike protein antig...