Encephalomyocarditis virus impairs the blood-brain barrier by degrading tight junction proteins via AKT3-dependent autophagic and apoptotic pathways.
Encephalomyocarditis virus (EMCV) infection causes viral encephalitis; however, the mechanisms underlying blood-brain barrier (BBB) disruption remain poorly understood. Here, we demonstrate that EMCV ...
Retinal vascular parameters as AI-driven biomarkers for pulse wave velocity assessment: a telemedicine strategy for cardiovascular risk assessment.
BACKGROUND: Pulse wave velocity (PWV), known as the gold standard for evaluating arterial stiffness, is limited by device dependence. This study aims to explore the feasibility of retinal parameters t...
Impact of ASO conjugation and receptor binding affinity on intracellular transport of mono- and bispecific TfR- and CD98-Brainshuttle(TM) variants.
Antisense oligonucleotides (ASOs) represent a promising therapeutic modality for central nervous system (CNS) disorders, offering highly specific modulation of gene expression. However, their clinical...
Unveiling the cognitive fog in lung cancer patients: non-invasive exploration of blood-brain barrier disruption and brain structural changes.
BACKGROUND: This study investigates the correlation between blood-brain barrier (BBB) damage and cognitive impairment in patients suffering from untreated lung cancer. The study aims to understand the...
Effect of the modified RADAR, No-touch, and conventional techniques on arteriovenous fistula outcomes.
OBJECTIVE: Low primary patency rates represent a major problem of radiocephalic arteriovenous fistula (RC-AVF). No-touch techniques and radial artery deviation and reimplantation (RADAR) were reported...
Development and internal validation of a preprocedural prediction model for failed umbilical venous catheterization in neonates.
OBJECTIVE: Umbilical venous catheterization (UVC) may fail because of resistance during catheter advancement, malposition, impaired catheter function, or procedure termination. Preprocedural predictor...
Chromosomal abnormalities and pregnancy outcomes in 350 pregnancies with prenatally diagnosed aberrant right subclavian artery: a phenotype-based retrospective cohort study.
BACKGROUND: Aberrant right subclavian artery (ARSA) is the most frequent aortic-arch branching variant on prenatal sonography, and its clinical relevance is governed by the phenotypic context in which...
Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model.
Three main contributors to cardiomyocyte diastolic stiffness are (1) passive sarcomere stiffness, (2) microtubules, and (3) diastolic crossbridges (XBs), the XBs that are present in the diastolic phas...
Prunasin alleviates OGD/R-induced injury in H9c2 cardiomyocytes via SRC/EGFR-AKT-FoxO-mediated mitochondrial quality control.
BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) is still difficult to manage clinically, mainly due to limited effective strategies that can simultaneously address oxidative stress, mitochon...
The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor-αKlotho Complex Increases Sinoatrial Electrical Activity.
AIM: This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body pho...
Hypotonicity-Induced WNK1 Phosphorylation Prevents H(2)O(2)-Induced Apoptosis in Vascular Smooth Muscle Cells.
Vascular smooth muscle cells (VSMCs) are essential for maintaining arterial wall integrity, with their associated apoptosis critically involved in cardiovascular diseases. Intracellular chloride anion...
Oxytocin Affects Barriergenesis in the Blood-Brain Barrier and the Blood-Cerebrospinal Fluid Barrier In Vitro Monoculture Transwell Models.
The integrity of the brain's barrier systems-the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB)-is crucial for central nervous system homeostasis. Oxytocin (OXT), a neuropepti...
Finerenone Alleviates Cardiac Microvascular Injury and Neutrophil Extracellular Traps Formation in Diabetic Cardiomyopathy via Regulating AKT1 Phosphorylation.
BACKGROUND: Diabetes mellitus is commonly featured with cardiac microvascular dysfunction and chronic low-grade inflammation, contributing to the progression of diabetic cardiomyopathy (DCM). Finereno...
Assessing clinical outcomes in cirrhotic patients with thromboembolic complications.
BACKGROUND: Cirrhosis produces a rebalanced hemostatic state that predisposes patients to bleeding and thrombosis. We evaluated hepatic outcomes associated with deep vein thrombosis (DVT), pulmonary e...
The additive value of coronary calcium in identifying cardiovascular risk in ageing people with HIV.
In people without HIV, raised coronary artery calcium scores (CACS) are linked to increased cardiovascular risk. HIV is associated with elevated CACS, but risk factors beyond smoking and diabetes are ...
Complications of Transcatheter Aortic Valve Replacement: Contemporary Prevention, Recognition, and Management.
This review summarizes contemporary prevention, recognition, and management of major complications after transcatheter aortic valve replacement. The article emphasizes anatomy-specific planning with m...
Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity.
The expansion of transcatheter aortic valve replacement (TAVR) into younger and lower-risk populations has heightened attention toward long-term valve durability. Hypoattenuated leaflet thickening (HA...
Conduction Disturbances and Pacing after Transcatheter Aortic Valve Replacement: Mechanisms, Risk Stratification, and Management.
Conduction disturbances are common after transcatheter aortic valve replacement and significantly influence postprocedural management and outcomes. These abnormalities arise from the close anatomic re...
Valve-In-Valve Transcatheter Aortic Valve Replacement: Advances in Planning, Technique, and Lifetime Management.
Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) has emerged as a key reintervention strategy for failed surgical bioprostheses. Meticulous preprocedural planning with computed tomogra...
Transcatheter Aortic Valve Replacement for Native Aortic Regurgitation.
Aortic regurgitation (AR) is a common valvular heart disease with an estimated prevalence of greater than 4% among patients aged greater than 65 years in some series. If left untreated, AR is associat...