Transcatheter Aortic Valve Replacement with a Self-expanding Prosthesis.

Self-expanding transcatheter valves have evolved significantly into mature therapeutic platforms supported by randomized evidence across the spectrum of surgical risk. The most consistent advantages o...

Alternative Access for Transcatheter Aortic Valve Replacement: A Comprehensive Updated Review.

Transfemoral is the most widely used and remains the preferred approach to perform Transcatheter aortic valve replacement (TAVR) in the vast majority of patients because of its superior clinical outco...

Treatment of Bicuspid Aortic Valve Stenosis Using Transcatheter Heart Valves.

The paucity of data from randomized clinical trials regarding the use of transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve anatomy due to exclusion from pivotal studies continues ...

Balloon-Expandable Transcatheter Aortic Valve Replacement: A Comprehensive Review of Current Evidence and Clinical Outcomes.

This article outlines the transformative impact of transcatheter aortic valve replacement (TAVR) since its first successful human use in 2002, redefining the management of severe aortic stenosis. Trad...

Beyond the First Valve: A Longitudinal Framework for Aortic Valve Replacement Selection.

The growing population of patients expected to outlive their index aortic valve replacement (AVR) demands a fundamental shift in treatment planning to one that treats the first valve as the opening co...

A modified model of cardiac reverse remodeling following abdominal aortic banding and debanding in rats.

OBJECTIVE: Cardiac reverse remodeling (RR) after pressure unloading has been widely studied using abdominal aortic banding (AB) and debanding (DB) models. However, the DB procedure is technically chal...

Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.

OBJECTIVE: To compare pulmonary function and biomarkers of endothelial injury between hemodialysis patients with end-stage renal disease (ESRD) and kidney transplant (KT) recipients. METHODS: Cross-se...

Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis.

Diabetic cardiomyopathy (DCM) is a major complication of type 1 diabetes mellitus (T1DM) with limited treatment options. Dyrk1a is involved in multiple diseases, comprising neurodegenerative disorders...

Natural polysaccharides modulate the microbiota-gut-brain axis through multiple targets: A new perspective on the pathogenesis and treatment of depression.

Depression is increasingly understood as a systemic disorder involving microbiota-gut-brain axis (MGBA) dysfunction rather than only central monoaminergic imbalance. Gut microbial dysbiosis, barrier d...

GPR30 Functions as a Shared Inhibitory Signal for Both Pericyte-Mediated Angiogenesis and Oligodendrocyte Myelination.

Myelinogenesis is insufficient in numerous myelin-related diseases in the CNS, leading to functional impairments. Myelinogenesis couples with angiogenesis to ensure adequate need of oxygen and nutrien...

Müller Glia-Vasculature Interactions in the Developing Retina.

Coordinated signaling among neurons, glia, and the vasculature is essential for nervous system development. In the developing retina, spontaneous cholinergic retinal waves are the primary source of ne...

Effect of Buerger-Allen Exercises on Lower Extremity Perfusion in Diabetes Mellitus Patients Undergoing Coronary Artery Bypass Grafting With Saphenous Vein Harvesting: A Randomized Controlled Trial.

BACKGROUND & PURPOSE: Patients with diabetes mellitus undergoing coronary artery bypass grafting (CABG) with saphenous vein harvesting are at increased risk of impaired lower extremity perfusion and w...

Berberine ameliorates doxorubicin-induced cardiac toxicity via regulation of the SNHG14/miR-9-5p/PDK4 axis.

BACKGROUND: Doxorubicin (Dox) has limited clinical application due to its cardiotoxicity. Berberine (Ber) counteracts Dox-induced myocardial injury. OBJECTIVES: This study uncovers molecular mechanism...

Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea.

BACKGROUND: Brassica oleracea L. (Brassicaceae), commonly known as cabbage, is usually used for dietary purposes and is also known for many medicinal uses, including blood pressure. OBJECTIVES: The cu...

Antihypertensive and vasorelaxant effects of 2-methoxystypandrone mediated via multiple vascular mechanisms.

BACKGROUND: 2-Methoxystypandrone (2-MS), a naphthoquinone from Reynoutria japonica Houtt., has diverse pharmacological activities. However, its antihypertensive and vascular effects remain unexplored....

Oxadiazolone-Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II-Induced Vascular Contraction.

In this study, a series of novel angiotensin II type 1 receptor (AT1R) antagonist candidates containing the 1,2,4-oxadiazol-5-one nucleus and a 1,2,3-triazole moiety was designed, synthesized, and eva...

Discovery of Ro 41-0960, a Non-Steroidal Inhibitor of the Na(+)/K(+)-ATPase.

The Na+/K+-ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure. Yet, cardiotonic steroids used in clinical practice are limited by a narrow therapeu...

A Topological and Spatial Analysis of FDA-Approved Drugs, Blood-Brain Barrier Permeants, Natural Products, and Metabolites.

In this study, we present a comprehensive structural analysis of four distinct chemical libraries: FDA-approved drugs, blood-brain barrier (BBB) permeable agents, natural products (UNPDA), and human m...

YTHDF1-mediated m(6)A RNA regulation controls cardiomyocyte remodeling through KLF11-HIF1α.

Cardiovascular disease remains the leading cause of mortality globally. Although cardiac hypertrophy initially serves as a compensatory adaptation to stress, physiological and pathological hypertrophy...

Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease.

Atherosclerotic cardiovascular disease (ASCVD), the leading cause of mortality worldwide, is driven by endothelial cell (EC) inflammatory activation and counterbalanced by protective mechanosensitive ...