Capillary endothelial cell heterogeneity in skeletal muscle of female and male mice.
In skeletal muscle, capillaries have been shown to be critical to active hyperemia by sensing skeletal muscle activity and directing blood flow to contracting muscle fibers. There is evidence to sugge...
Early Functional Recovery and Myocardial Deformation Improvement After Transcatheter VSD Closure: A 3D Speckle-Tracking Echocardiography Study.
BACKGROUND: Transcatheter closure of ventricular septal defects (VSDs) has become a widely accepted alternative to surgical repair, owing to its high success rates and lower risk of complications. Adv...
CT-Based Reference Ranges for Canine Pyloric Thickness: Influence of Body Size and Normalization With Aortic Diameter.
Pyloric wall thickness reflects pyloric pathology. Prior related studies included small samples and did not consistently measure perpendicular to the pyloric axis. This multicenter retrospective study...
Catheter configuration for mapping micro-anatomic reentries sustaining atrial fibrillation: A simulation study.
Atrial fibrillation (AF) can be sustained by intramural reentrant circuits within three-dimensional arrhythmogenic hubs formed by fibrotically-insulated myobundles. However, the efficacy of different ...
The Super Thin External Pudendal Artery Free Flap for Buccal Reconstruction: A Case Report.
Reconstruction of buccal mucosal defects requires thin, pliable, and well-vascularized tissue to preserve oral function and cheek mobility. While the radial forearm free flap remains widely used, alte...
The Effect of the Coexistence of Hair Follicle and Perforator Artery Density on Length of Hospital Stay in Burns.
Whilst total body surface area, burn depth and age are established determinants of hospital stay, the independent influence of the anatomical region's biological microenvironment remains unexamined. T...
S100A9 Aggravates Cardiac Fibrosis by TLR4/PGC-1α Mediated Macrophage-Myofibroblast Crosstalk.
Fibrosis is a critical component of ventricular remodelling after myocardial ischemia, and the activation and expansion of cardiac fibroblasts represent key drivers of this process. Our previous work ...
Panoramic hyperspectral optical mapping of cardiac membrane potential and tissue type.
SIGNIFICANCE: Cardiac panoramic optical mapping is a powerful approach for studying action potential dispersion and mapping arrhythmia triggers and propagation pathways over the entire surface of the ...
Ultrasonographic Measurement of Kidney-to-Aorta Parameters in French Bulldogs.
Ultrasonographic kidney size assessment requires normalization to body size; the kidney length-to-aorta diameter (KL/AoD) ratio improves diagnostic accuracy, yet reference ranges vary across breeds. T...
Change in pulmonary artery pressure upon acute exposure to high altitude: a systematic review and meta-analysis.
BACKGROUND/RESEARCH QUESTION: We investigated the increase in pulmonary artery pressure (PAP) with altitude gain in healthy low-altitude residents travelling to high altitude, analysing reported measu...
Long-term durability of self-expandable transcatheter heart valves in bicuspid versus tricuspid aortic valve stenosis: a matched-cohort analysis.
BACKGROUND: A bicuspid aortic valve (BAV) presents unique challenges for transcatheter aortic valve implantation (TAVI), and evidence on long-term bioprosthetic durability in an BAV compared to a tric...
Midazolam-induced underestimation of mitral regurgitation severity and its pharmacological reversal with flumazenil.
BACKGROUND: Sedative agents may alter hemodynamic status and influence the echocardiographic assessment of mitral regurgitation. Although anesthesia-related underestimation of mitral regurgitation has...
MiR-143-3p serves as a novel biomarker for diabetic cardiomyopathy and is involved in regulating high glucose-induced cardiomyocyte injury.
ObjectiveThis work aimed to verify the value of miR-143-3p in diabetic cardiomyopathy (DCM).MethodsThe ROC curve, correlation analysis, and multivariate Logistic regression analysis assessed the diagn...
LAG3 Gene Therapy Attenuates Autoimmune Uveitis by Regulating the PI3K/Akt Signaling Pathway.
PURPOSE: Lymphocyte-activation gene 3 (LAG3) is a critical immune checkpoint molecule, yet its role and mechanisms in autoimmune uveitis remain inadequately understood. This study sought to elucidate ...
Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation.
Cushing's disease (CD), the most common endogenous Cushing's syndrome, is caused by activating mutations in the ubiquitin-specific protease 8 (USP8) gene. These mutations drive adrenocorticotropic hor...
Thiol-Based Neuroprotective Copolymers Acutely Restore Redox Metabolism and Mediate Vasogenic Edema in a Mouse Model of Traumatic Brain Injury.
Effective pharmaceutical interventions for treating the secondary damage associated with traumatic brain injury (TBI) are limited due to poor delivery into the brain, insufficient target engagement, a...
Endovascular Treatment of Intrahepatic Hepatic Artery Pseudoaneurysms: Safety and Efficacy According to Embolization Strategies.
Background Intrahepatic hepatic artery pseudoaneurysm (IHPA) is a rare, life-threatening vascular complication requiring prompt endovascular management, yet comparative data on embolization approaches...
Quantitative Susceptibility Mapping Shows Size-dependent Focused Ultrasound-mediated Therapeutic Delivery to Naive Brain and Gliomas in Mice.
Background Focused ultrasound US (FUS)-mediated disruption of the blood-brain barrier (BBB) and blood-tumor barrier (BTB) augments therapeutic delivery; however, relationships between dose, agent size...
TMEM87a Maintains Cardiomyocyte Integrity by Limiting Ferroptosis in Dilated Cardiomyopathy.
Dilated cardiomyopathy (DCM) is a major cause of heart failure, but the organelle-level mechanisms linking cardiomyocyte stress to maladaptive remodeling remain incompletely defined. Transmembrane pro...
Clinical Presentation and Treatment Response in Women With Acetylcholine-Confirmed Coronary Spasm: A Single-Center Observational Study.
BACKGROUND: Coronary vasomotor disorders are frequently underdiagnosed in women with angina and non-obstructive coronary arteries. We investigated clinical presentation, diagnostic delay, spasm subtyp...