Vasoplegia is a recognized complication of cardiopulmonary bypass (CPB), yet its prevalence and clinical impact after heart transplantation (HT) remain incompletely defined, particularly when primary ...

Modifier genes may cause different clinical phenotypes in patients with long QT syndrome (LQTS) carrying the same pathogenic variant. Variants in the MTMR4 gene have been previously associated, via pa...

Conduction system pacing (CSP), which encompasses His bundle pacing and left bundle branch area pacing, has resulted in a paradigm shift in the management of patients with bradycardia pacing indicatio...

Neurogenic diarrhoea after superior mesenteric artery divestment or resection for pancreatic adenocarcinoma following preoperative chemotherapy: international multicentre retrospective study.

BACKGROUND: The increased use of superior mesenteric artery (SMA) divestment has been a driver behind the increased resection rate for locally advanced pancreatic cancer following preoperative therapy...

A Microfluidic System for Modeling Endothelial Dysfunction under Combined Physiological Pulsatile Shear Stress and Oscillatory Hyperglycemia.

Endothelial dysfunction in diabetic vascular complications involves complex interactions between metabolic disturbances, specifically oscillatory glucose (OG) and pulsatile shear stress (PSS). Althoug...

Comparative long-term risks of chronic kidney disease and dialysis following conservative treatment, renal artery embolization, or nephrectomy in patients with blunt kidney injuries: retrospective cohort study.

BACKGROUND: Long-term changes in renal function following blunt kidney injury (BKI) remain insufficiently studied, particularly in patients who undergo renal artery embolization (RAE). The aim of this...

Atrial fibrillation (AF) frequently coexists with heart failure (HF) and is associated with increased mortality and HF hospitalization. The long-term clinical benefit of catheter ablation (CA) compare...

Frontal T-wave axis (TA) and QRS-T angle (QRSTA) are automated ECG measures that reflect depolarisation-repolarisation abnormalities-and have been linked to mortality. We tested whether increasing dev...

The European Society of Cardiology (ESC) diagnostic criteria for infective endocarditis (IE) were updated in 2023. Using a prospective multicentre cohort of patients treated for IE, we compared the pe...

High donor sequence number (DSN) donor hearts are often regarded as low quality, despite studies suggesting otherwise, and thus declined. There is a paucity of literature on high DSN transplant outcom...

The International Association for the Study of Lung Cancer (IASLC) proposed a novel grading system for invasive non-mucinous adenocarcinoma. This study aimed to evaluate the accuracy of intraoperative...

Early identification of individuals with pre-heart failure (pre-HF) is essential for preventing heart failure (HF) development. Heart stress, defined by age-specific elevations in N-terminal pro-B-typ...

A patient with end-stage liver disease, aortic stenosis and rapid progression of an aortic root pseudo-aneurysm underwent successful combined heart-liver transplantation. A 56-year-old female with dec...

Becoming a successful congenital cardiac surgeon requires the investment of senior surgeons in sponsorship, apprenticeship and mentorship. The recent congenital workforce survey revealed distinct conc...

The standard of care for stage I non-small cell lung cancer (NSCLC) is curative-intent surgical resection without adjuvant therapy. However, many patients experience recurrence or death after surgery....

Tinnitus is a highly prevalent and distressing symptom in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). While international clinical guidelines primarily focus on hearing recove...