ZIKV NS3 disrupts Nrf2-mediated antioxidant defense and drives vascular smooth muscle cell damage and vascular dysfunction.
Zika virus (ZIKV) infection has been linked to vascular complications, yet the basis of vascular injury after apparent clearance of circulating virus remains poorly understood. This study examined the...
Iron deficiency (ID) is common in patients with heart failure with preserved ejection fraction (HFpEF). The IRON-HFpEF trial aimed to evaluate the mechanistic effects of intravenous iron supplementati...
Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder marked by extremely elevated low-density lipoprotein cholesterol (LDL-C) levels from birth and a very high risk of premature...
Fatal ventricular tachyarrhythmias (FVTs) are a major cause of sudden cardiac death globally. Despite their clinical importance, current antiarrhythmic therapies remain constrained by limited efficacy...
Abdominal adiposity may contribute to both general and cardiovascular ageing, yet the extent to which accelerated biological age (BA) at distinct molecular levels mediates these effects has not been f...
Individuals with prediabetes face an increased risk of cardiovascular (CV) complications, which can ultimately lead to premature mortality. However, existing risk stratification tools are not targeted...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) provide substantial cardiovascular benefits across a broad spectrum of patients at high atherosclerotic risk. However, evidence for their cardiovascu...
The triglyceride-glucose (TyG) index and triglyceride-glucose-body mass index (TyG-BMI) are emerging surrogate markers of insulin resistance and metabolic risk. However, their comparative prognostic v...
Cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 represent a critical window for preventing progression to overt cardiovascular disease (CVD). Insulin resistance (IR) is central to CKM pathop...
Durable pulmonary vein isolation (PVI) is considered the "Achilles' heel" of atrial fibrillation (AF) ablation. While pulsed field ablation (PFA) is increasingly utilized due to its non-thermal, tissu...
The effects of chronic administration of Cannabidiol and Cannabidiol-Selexipag combination on haematological parameters, oxidative stress, BNP, and TNF-α in a rat model of Pulmonary Arterial Hypertension.
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vasoconstriction and inflammation, leading to increased pulmonary pressure, right heart failure, ...
Valvular heart disease (VHD) accounts for significant morbidity and mortality during pregnancy, with limited data to guide cardio-obstetric risks. This is a retrospective cohort study describing mater...
Atrial fibrillation (AF) coexists with left ventricular diastolic dysfunction (LVDD), but the impact of catheter ablation across LVDD stages is unclear. The study aimed to quantify AF ablation effects...
Left main disease represents one of the most complex lesion subsets for percutaneous coronary intervention, associated with an increased risk of serious late complications. The recent endorsement of i...
A previous trial of intravenous immunoglobulin therapy (IVIg) added to guideline-directed medical therapy (GDMT) in patients with dilated cardiomyopathy (DCM) and cardiac parvovirus-B19 (B19V) persist...
Repair of completely lost mitral leaflet segments is technically challenging, particularly via minimally invasive cardiac surgery. We report a case of iatrogenic mitral regurgitation following cathete...
Iron deficiency occurs commonly in chronic kidney disease (CKD), but its association with heart failure and other cardiovascular outcomes, independent of anemia, is not well defined.
It is assumed that complete balloon occlusion is necessary for effective lesion formation in retrograde coronary venous ethanol infusion for ventricular arrhythmias.
Fabry disease (FD) is a rare X-linked genetic disorder due to alpha-galactosidase deficiency. Cardiovascular complications, including ventricular arrhythmias and conduction abnormalities, constitute t...
Congenital critical aortic stenosis (AS) is frequently accompanied by endocardial fibroelastosis (EFE), impairing diastolic compliance and long-term ventricular performance. An early Ross procedure, w...