The Role of Mechanical Circulatory Support Devices in Heart Failure Cardiogenic Shock.
Heart failure (HF) cardiogenic shock (CS) remains a highly morbid condition with scarce data for utilization of temporary mechanical circulatory support. Consensus statements from major societies aid ...
[Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i): A Therapeutic Revolution Beyond Diabetes. New Indications in Non-Diabetic Chronic Kidney Disease and Heart Failure].
Sodium-Glucose Co-Transporter 2 Inhibitors (SGLT2i), initially developed as hypoglycemic agents, have revolutionized the management of cardiorenal diseases due to potent organ-protective effects. Evid...
Beyond the slope: prognostic utility of the VE/VCO(2) intercept in chronic heart failure.
AIMS: Cardiopulmonary exercise testing (CPET) parameters are used for heart failure (HF) prognostication. While the ventilation to carbon dioxide production (VE/VCO2) slope ≥34 identifies high risk, p...
Development and Internal Validation of a Vectorcardiography-Augmented Model for 12-Month Major Adverse Cardiovascular Events in Chronic Heart Failure.
To develop and internally validate a vectorcardiography (VCG)-augmented model for estimating 12-month major adverse cardiovascular events (MACE) in hospitalized patients with chronic heart failure (CH...
Bioenergetics-Driven Extracellular Vesicle Therapies for Heart Failure: From Preclinical Insights to Regenerative Translation.
Heart failure (HF) is fundamentally a disease of energetic insufficiency, in which impaired mitochondrial efficiency, maladaptive metabolic remodeling, and disrupted intercellular signaling converge a...
First Insights into Sensor-Based Ballistocardiographic Measurements in Patients with Heart Failure.
Heart failure significantly impacts morbidity, mortality, physical functionality, and quality of life, presenting a high financial burden to healthcare systems. Early detection through non-invasive me...
Association of Remote Patient Monitoring with Care Utilization in Patients with Chronic Cardiopulmonary Conditions.
Remote patient monitoring (RPM) has shown potential benefits for patients with chronic conditions. This study aimed to compare healthcare utilization between RPM and non-RPM patients with congestive h...
Late diagnosis of late onset Fabry disease.
A male in his 50s initially presented with left ventricular hypertrophy (LVH) identified on transthoracic echocardiogram. He was diagnosed with hypertrophic cardiomyopathy without any further investig...
Cost-Effectiveness Analysis of Age-Specific N-Terminal Pro-B-Type Natriuretic Peptide Thresholds for Heart Failure Diagnosis in China: Protocol for a Markov Model-Based Study.
BACKGROUND: Heart failure (HF) imposes a substantial clinical and economic burden in China. Although N-terminal pro-B-type natriuretic peptide (NT-proBNP) is widely used in the diagnostic pathway for ...
Serum Copper-to-Zinc Ratio and Oxidative Stress Are Associated with Anemia in Older Adults with Cardiovascular-Kidney-Metabolic Syndrome.
Chronic oxidative stress is a molecular hallmark of cardiovascular-kidney-metabolic (CKM) syndrome, yet its contribution to CKM-associated anemia beyond erythropoietin deficiency and iron restriction ...
Beyond vasodilation: sotatercept and the remodeling hypothesis in hfpef-associated pulmonary hypertension.
Pulmonary hypertension complicating heart failure with preserved ejection fraction (HFpEF), particularly the combined post- and pre-capillary form (CpcPH), has lacked any mechanism-specific therapy, a...
The Prognostic Impact of the Cachexia Index in Patients Hospitalized with Heart Failure.
Background and Objectives: Cachexia is a systemic wasting syndrome associated with poor outcomes in chronic diseases, including heart failure (HF). Although the cachexia index (CXI), which integrates ...
Transcriptome Reprogramming in Heart Failure: The Hidden Splicing Code.
PURPOSE OF REVIEW: Heart failure remains a major cause of morbidity and mortality that is associated with myocardial changes in metabolism, contractile function, and molecular remodeling. Cardiomyopat...
Sirtuins at the Interface of Glucose Metabolism, Diabetes, and Heart Failure: Metabolic Sensing in Cardiometabolic Disease.
Heart failure (HF) in the setting of diabetes represents a distinct cardiometabolic phenotype characterized by profound disturbances in myocardial glucose metabolism, mitochondrial function, and energ...
Istaroxime in Acute Heart Failure and Early Cardiogenic Shock: A Calcium-Cycling Approach to Inotropic Therapy.
Acute heart failure (AHF) and cardiogenic shock (CS) remain major causes of cardiovascular morbidity, mortality, and healthcare utilization worldwide. Although inotropic agents are central to the mana...
Identification of Candidate Biomarkers Associated with Mitochondrial Dysfunction and SUMOylation in Heart Failure Based on Bioinformatics Approaches.
Heart failure (HF) presents a persistent clinical challenge. While SUMOylation and mitochondrial function are vital for cardiomyocyte health, their combined influence on HF remains elusive. Two HF-rel...
Vitamin D as a mediator in the J-shaped association between serum uric acid and all-cause and cardiovascular mortality in patients with cardiovascular-kidney-metabolic syndrome: A prospective cohort study.
The relationship between serum uric acid (UA) and mortality in patients with cardiovascular-kidney-Metabolic (CKM) syndrome remains unclear. We hypothesized that elevated UA increases mortality nonlin...
Albumin-corrected anion gap and mortality risk in cardiorenal syndrome: Insights from a nationally representative cohort study.
The prognostic significance of the albumin-corrected anion gap (ACAG) in patients with cardiorenal syndrome (CRS) remains unclear. This study aimed to examine the association between ACAG and all-caus...
The uric acid-to-high-density lipoprotein cholesterol ratio, neutrophil-to-high-density lipoprotein cholesterol ratio, and lymphocyte-to-high-density lipoprotein cholesterol ratio as risk indicators for mortality in congestive heart failure: A cross-sectional analysis of NHANES 2003 to 2016.
While individual lipid and inflammatory markers have been linked to heart failure outcomes, the prognostic value of the uric acid-to-high-density lipoprotein (HDL) cholesterol ratio (UHR), neutrophil-...
Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial.
INTRODUCTION: Guideline-directed medical therapy (GDMT) has been demonstrated to reduce morbidity and mortality in patients with heart failure (HF). In addition to the need for GDMT, a large number of...