Large animal models of right heart failure due to pulmonary hypertension: a bridge to translational success.
Right heart failure drives morbidity and mortality in pulmonary arterial hypertension (PAH). At present, there are no chronic pharmaceutical interventions that directly augment right heart function in...
Restrictive vs Liberal Transfusion Strategy After Myocardial Infarction: A Post Hoc Analysis of the MINT Randomized Clinical Trial.
IMPORTANCE: The decision to transfuse a patient with myocardial infarction (MI) and anemia at a higher vs lower hemoglobin threshold must consider the potential benefit of reduced risk of 30-day death...
Renal resistance index reveals 'driving effect' of vericiguat for heart failure therapy: the possible way for guideline-directed medical therapy implementation?
BACKGROUND: Guideline-directed medical therapy (GDMT) improves outcomes in heart failure. Continuous dose titration of GDMT is mandatory to reduce heart failure morbidity and mortality. The renal resi...
Clinical congestion patterns in patients with advanced heart failure: an analysis of the HELP-HF Registry.
BACKGROUND: The impact of different clinical congestion phenotypes in advanced heart failure (HF) has not been fully investigated. We aimed to evaluate congestion patterns in patients with advanced he...
Durable ventricular assist device implantation after acute myocardial infarction: an analysis of the EUROMACS registry.
INTRODUCTION: Patients undergoing durable ventricular assist device (VAD) implantation after acute myocardial infarction (AMI) present critical surgical and clinical challenges. Data on outcomes in th...
Prognostic Utility of the Total Body Muscle Mass in Heart Failure: Insights From the JEDI-AHF Registry.
AIM: Quantifying skeletal muscle mass is essential for patients with heart failure; however, common modalities, such as bioelectrical impedance analysis, can be distorted by fluid retention. The total...
Hemoglobin Glycation Index and Prognosis in Patients With Acute Myocardial Infarction Without Reduced Left Ventricular Ejection Fraction: A Multicenter Retrospective Cohort Study.
BACKGROUND: The prognostic value of the hemoglobin glycation index (HGI) in patients with acute myocardial infarction (AMI) without reduced left ventricular ejection fraction (LVEF) remains unclear. M...
Center Differences in PreTransplant Functional Status and Its Association With Survival After Heart Transplantation.
BACKGROUND: The Karnofsky Performance Scale (KPS) is widely used to assess functional status in heart transplantation (HT) candidates and inform risk stratification. However, its subjective nature rai...
More Than a New Heart: Psychological Adjustment and Quality of Life Following Heart Transplantation, a Mixed-Methods Study.
INTRODUCTION: Heart transplantation (HTx) offers life-saving treatment for advanced heart failure. While physical recovery is well-documented, psychological recovery and health-related quality of life...
Advanced Medical Care at Home Among Patients With Acute Heart Failure.
IMPORTANCE: Contemporary data regarding the safety and quality of acute hospital care at home for heart failure (HF) are limited. OBJECTIVE: To compare safety and quality outcomes of an advanced medic...
[Epidemiology and burden on the National Health Service of cardiomyopathy associated with transthyretin amyloidosis based on administrative health data.].
RATIONALE: This study analyses, within Italian clinical practice, the epidemiology, healthcare resource utilization, and direct costs for the National Health Service (NHS) of patients with transthyret...
Unintended Financial Barriers: When "Generic" Does Not Mean Affordable.
Sacubitril/valsartan is a foundational component of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF), demonstrating reductions in cardiovascular morta...
Association Between the Red Blood Cell Distribution Width-to-Albumin Ratio, Nursing Notes, and the Length of Hospital Stay in Iron Deficiency Anaemia Complicated With Congestive Heart Failure Patients.
AIMS: To evaluate the influence of the red blood cell distribution width-to-albumin ratio (RAR) and sentiment scores from nursing notes on the length of hospital stay (LOS) and mortality risk among ir...
The Association Between Bending Photoplethysmography Waveform Area Index and Congestive Heart Failure.
AIMS: Congestive heart failure (CHF) is closely associated with a decrease in cardiac output, and photoplethysmography (PPG) parameters can experimentally assess cardiac output. It is unclear whether ...
Comparative effectiveness of tirzepatide and DPP-4 inhibitors in type 2 diabetes with heart failure.
While patients with type 2 diabetes mellitus (T2DM) and heart failure (HF) are frequently prescribed dipeptidyl peptidase-4 inhibitors (DPP-4is), emerging evidence suggests glucagon-like peptide-1 rec...
Acute Left Heart Failure in Twin Pregnancies: Clinical Characteristics and Outcomes-A 10‑Year Retrospective Analysis of 24 Cases.
This retrospective study evaluated the clinical characteristics, management, and maternal-neonatal outcomes of 24 twin pregnancies complicated by acute left heart failure (ALHF) delivered at Peking Un...
Post-stroke acute heart failure in patients with large vessel occlusion undergoing endovascular treatment: A pooled analysis of individual patient data from multicenter studies with mediation analysis.
BACKGROUND: Cardiac complications rank among the leading contributors to poor outcomes in ischemic stroke patients along with the neurological impairment, while the risk stratification and prognostic ...
Comparing Ferric Carboxymaltose Versus Iron Sucrose in Patients with Heart Failure.
BACKGROUND: Limited evidence comparing different intravenous (IV) iron products is available to guide the optimal IV iron product in patients with heart failure (HF) and iron deficiency (IDef). OBJECT...
Associations of the C-Reactive Protein-Albumin-Lymphocyte Index, Red Cell Distribution Width-Albumin Ratio, and Blood Urea Nitrogen-Albumin Ratio With All-Cause and Cardiovascular Mortality Among Adults With Preclinical Heart Failure.
BACKGROUND: Preclinical heart failure (PHF) is an early stage in the heart failure continuum, yet practical indices for mortality risk assessment remain understudied. HYPOTHESIS: The C-reactive protei...
Utilisation of the Lactate/Albumin Ratio as a Mortality Predictor in Patients with Acute Heart Failure in the Emergency Department.
OBJECTIVE: To evaluate the effectiveness of the lactate/serum albumin (L/A) ratio in predicting 30- and 90-day all-cause mortality and 30-day all-cause readmissions in patients presenting to the emerg...