Subclass-Specific Impact of β(1)-Adrenergic Receptor Autoantibodies and Phenotype-Specific Interaction With β-Blockers in a Contemporary Population With Heart Failure.
BACKGROUND: The clinical significance of β1AR-AAb (β1-adrenergic receptor autoantibody) subclasses, particularly IgG3 (immunoglobulin G subclass 3), in contemporary populations with HF (heart failure)...
Absence of GDF15 Aggravates Pressure Overload-Induced Cardiac Remodelling in Mice Hallmarked by Perivascular Fibrosis and Signs of Endothelial-to-Mesenchymal Transition.
Growth differentiation factor 15 (GDF15) levels are associated with increased mortality and rehospitalisation in heart failure (HF) patients. Whether GDF15 is causally involved in the pathobiology of ...
Circulating nitric oxide pathway metabolites in heart failure with preserved ejection fraction: a sex-stratified cross-sectional analysis.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is more prevalent in women, who often present with earlier onset and greater severity of vascular and endothelial dysfunction. Nitric...
Smart Technology, Fragile Hearts: Navigating AI's Challenges and Limitations in Heart Failure Management.
PURPOSE OF REVIEW: This review synthesizes recent progress in applications of artificial intelligence to heart failure care, including phenotyping, risk stratification, imaging interpretation, and poi...
Timing of Coffee Intake Modifies Mortality Risk in Cardiovascular-Kidney-Metabolic Syndrome: A Cohort and Experimental Study.
The association between the timing of coffee consumption and mortality risk among individuals with cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. This study aims to identify patterns ...
Troponin T, Left Ventricular Ejection Fraction, and Tricuspid Regurgitation Velocity for Biomarker- and Echocardiography-Based Risk Stratification in Critically Ill Patients with Heart Failure.
Troponin T is a molecular marker of cardiomyocyte injury, whereas left ventricular ejection fraction (LVEF) and tricuspid regurgitation velocity (TRV) reflect downstream ventricular and cardiopulmonar...
Pulmonary congestion assessed by lung ultrasound in stable ambulatory patients with heart failure and preserved ejection fraction in primary care.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) accounts for a growing proportion of heart failure cases. Pulmonary congestion, particularly subclinical congestion, is often underes...
Vericiguat in the Post-Stabilization Phase of HFrEF: Targeting Residual Risk Across the Ischemia-Decompensation Continuum.
Vericiguat is currently indicated for patients with heart failure with reduced ejection fraction (HFrEF) following recent clinical worsening, based on evidence demonstrating a reduction in cardiovascu...
The Impact of Risk Factors and Comorbidities on Heart Failure in the Aging Population.
Heart failure (HF) represents a major and escalating public health challenge in the aging population. Older adults with HF frequently present with coexisting conditions such as hypertension, diabetes ...
Risk of Long-Term Clozapine Medication over Decades for Cardiac Adverse Events Including Heart Failure and Its Pathophysiology: A Japan and China Retrospective Cohort Analysis.
Background/Objectives: Clozapine is the sole antipsychotic approved for treatment-resistant schizophrenia, but it is a double-edged therapeutic option due to various lethal adverse reactions. This stu...
Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico.
BACKGROUND/OBJECTIVES: Diuretic resistance is a recognized complication in patients with heart failure (HF) and is associated with worse clinical outcomes; however, information regarding its frequency...
Predictors of Heart Failure in Pediatric Patients with End-Stage Kidney Disease Secondary to Nephrotic Syndrome.
Background and Objectives: To investigate prognostic risk factors and determine the incidence, clinical characteristics, and predictors of heart failure (HF) development in pediatric patients with end...
Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.
Heart failure with preserved ejection fraction (HFpEF) represents a complex syndrome strongly associated with aging, characterized by diastolic dysfunction, myocardial stiffness, and chronic low-grade...
Joint Relationship of Cardiovascular-kidney-metabolic Syndrome and Psoriasis with All-cause and Cause-specific Mortality in Adults: A Population-based Analysis.
Psoriasis has been associated with cardiovascular risk, but the combined association of psoriasis and cardiovascular-kidney-metabolic (CKM) syndrome with mortality remains unclear. This study examined...
Determinants of Adherence to a Ketogenic Diet in Patients with Heart Failure with Reduced Ejection Fraction.
Background: Dietary interventions in heart failure (HF) remain limited, with current guidance focused largely on sodium restriction. Ketone metabolism has emerged as a potential therapeutic target in ...
Complementary cardiac functional assessment using systolic time intervals and bioelectrical impedance analysis.
BACKGROUND: The Forrester classification remains a cornerstone for assessing haemodynamic status in heart failure, yet its clinical application is restricted by the invasiveness of right heart cathete...
Cardiac microcurrent therapy in heart failure: Mechanistic rationale, early clinical evidence, and future directions.
Despite major advances in guideline-directed medical therapy (GDMT), many patients with heart failure with reduced ejection fraction (HFrEF) remain symptomatic, with persistent limitations in function...
Differential Associations of Oxidative Biomarkers with Symptomatic and Systolic Severity in Heart Failure.
Background and Objectives: Oxidative stress is recognized as an important contributor to heart failure (HF) pathophysiology, but the relationships of individual oxidative and antioxidant biomarkers wi...
Association between SGLT2 inhibitors and outcomes after heart transplant in patients with type 2 diabetes: A systematic review and meta-analysis.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are recommended for multiple populations-type 2 diabetes (T2D), chronic kidney disease, and heart failure-but their role after heart transplant (HTX)...
An analysis of digoxin serum concentrations and influencing factors: A cross-sectional study from a tertiary hospital in China.
The digoxin drug has a narrow therapeutic window that requires regular blood concentration monitoring in a tertiary hospital. The concentration of a drug varies due to several factors. The factors may...