Hyperkalemia and its treatment: real-world evidence and managed care considerations supporting use of potassium binders.

An estimated 3.7 million adults in the United States have hyperkalemia. It commonly occurs in patients with chronic kidney disease (CKD) and/or heart failure (HF) and as a result of treatment with ren...

Right Ventricular End-Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.

BACKGROUND: Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is a syndrome in which right ventricular (RV) dysfunction influences prognosis. Conventiona...

The Impact of Pre-Transplant Ventricular Assist Device Support on Survival After Heart Transplantation in Pediatric Patients: A Systematic Review and Meta-Analysis of Reconstructed Time-To-Event Data.

OBJECTIVES: Heart transplantation is the gold standard therapy for pediatric end-stage heart failure. Ventricular assist devices (VADs) have improved waitlist survival, but their effect on post-transp...

Peritoneal dialysis in patients with heart failure - The Italian reality based on the Census 2024 of the Peritoneal Dialysis Project Group of the Italian Society of Nephrology.

Peritoneal dialysis has shown to reduce days of hospitalization, NYHA functional class and to improve slightly left ventricular ejection fraction in heart failure patients. For the first time, the nat...

Enhancing Patient-Centered Home Palliative Care for Heart Failure: A Concept Analysis to Guide Nursing Practice and Care Coordination.

To identify and describe components of the home-based palliative care model for patients with heart failure, re-conceptualize the process, and update the existing model to inform nursing research and ...

Mechanisms of Shengxian Quyu Decoction In Heart Failure Using an Untargeted Metabolomics and Network Pharmacology Approach In Rats.

Shengxian Quyu decoction (SXQY) has been suggested as a potential therapeutic strategy for heart failure (HF), but its therapeutic mechanisms remain unclear. This study investigated the therapeutic ef...

Immune cell-mediated effects of plasma lipids on heart failure: A two-step, two-sample Mendelian randomization study.

A growing number of studies have shown that plasma lipids and immune cells are related to the occurrence and development of heart failure (HF), but the causal relationship between them is unclear. The...

The clinical efficacy of Astragalus-containing Chinese patent medicines in the effective treatment of heart failure: A systematic review and network meta-analysis.

BACKGROUND: The incidence of cardiovascular diseases, particularly heart failure, has been rising year by year. Traditional Chinese medicines containing Astragalus have been widely used in clinical re...

Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.

Heart failure (HF) is a heterogeneous clinical syndrome characterized by phenotype-specific metabolic remodeling (e.g., ischemic vs. nonischemic, HF with HFrEF vs. HFpEF), with impaired metabolic flex...

[Development and reliability and validity testing of the Medication Literacy Scale for patients with chronic heart failure].

OBJECTIVES: Chronic heart failure (CHF) is characterized by high prevalence, high mortality, and high readmission rates. Optimized combination pharmacotherapy is the main approach to controlling clini...

SGLT2 inhibitor dapagliflozin treats heart failure with preserved ejection fraction via the SIRT1/PGC-1α pathway.

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated clinical benefits in heart failure with preserved ejection fraction (HFpEF), yet the underlying mechanisms remain poorly defined. G...

Beyond the Powerhouse: Mitochondrial Crosstalk as a Master Regulator of Cardiac Metabolic Homeostasis and Failure.

Mitochondrial dysfunction has long been recognized as a central driver of heart failure (HF) pathogenesis, and emerging evidence highlights that impaired mitochondrial communication, rather than merel...

LightGBM-Based Classification of Heart Failure Phenotypes Using Morpho-Energy Features from High-Resolution ECG.

Heart failure (HF) remains a major global health challenge, necessitating accurate yet accessible diagnostic tools. While the left ventricular ejection fraction (LVEF) is the primary metric for classi...

GLP-1 Receptor Agonists in the Rehabilitation of Patients with Heart Failure: Mechanisms, Clinical Evidence, and Future Perspectives.

Heart failure (HF) remains associated with high morbidity and mortality, with heart failure with preserved ejection fraction (HFpEF) becoming increasingly prevalent and therapeutically challenging des...

Heart Failure Etiology and 6-Month Cardiorenal Recovery Patterns After Early In-Hospital SGLT2 Inhibitor Initiation in HFrEF: A Prospective Real-World Cohort.

Background: SGLT2 inhibitors improve outcomes in heart failure with reduced ejection fraction (HFrEF), but whether early recovery patterns after initiation differ according to HF etiology in real-worl...

[Capacity Management During the Hospital-to-Home Transition Period for Patients With Chronic Heart Failure].

OBJECTIVE: Exploring the effects of the hospital-to-home transitional capacity management plan in patients with chronic heart failure. METHODS: Patients with chronic heart failure who were hospitalize...

Factors Associated With Glycemic Variability in Hospitalized Patients With Type 2 Diabetes Mellitus and Heart Failure.

AIMS/BACKGROUND: Patients with concomitant heart failure (HF) and type 2 diabetes mellitus (T2DM) are at high risk for adverse clinical outcomes. Glycemic variability (GV) has emerged as a crucial met...

Urine sodium concentration and diuretic responsiveness in dogs receiving orally administered loop diuretics for chronic congestive heart failure.

BACKGROUND: Urine sodium concentration (uNa) measures diuretic responsiveness (DR) in acute congestive heart failure (CHF). In humans with chronic CHF receiving loop diuretics PO, low uNa is associate...

Rare stability in dogs with myxomatous mitral valve disease: Clinical observations of loop diuretic withdrawal after congestive heart failure.

BACKGROUND: Myxomatous mitral valve disease (MMVD) is a common cause of congestive heart failure (CHF) in small-breed dogs. Clinical observations suggest that discontinuation of loop diuretics may be ...

[Patient education in heart failure].

Heart failure is a chronic disease that leads to disabling symptoms and recurrent hospitalizations, mainly for acute heart failure episodes, having a major impact on patients' quality of life. An effe...