Sex-based differences in clinical outcomes among patients with obesity and heart failure with preserved ejection fraction treated with tirzepatide.

BackgroundSex-related differences are well recognized in heart failure with preserved ejection fraction (HFpEF), but real-world data describing clinical outcomes by sex among patients with obesity and...

Development and Evaluation of a Clinical Prediction Model for Acute Kidney Injury Risk in Elderly Patients with Heart Failure with Reduced Ejection Fraction.

BACKGROUND: Acute kidney injury (AKI) is a significant complication among patients with heart failure with reduced ejection fraction (HFrEF). Once AKI occurs, therapeutic options are limited to suppor...

A rare coexistence of immunoglobulin light chain amyloidosis and POEMS syndrome manifesting as refractory heart failure: a case report and literature review.

Immunoglobulin light chain (AL) amyloidosis and POEMS syndrome are plasma cell proliferative disorders involving multiple organs and tissues, often presenting with nonspecific clinical manifestations....

Sacubitril/Valsartan versus Enalapril or Losartan at Maximum Doses in Heart Failure with Reduced Ejection Fraction: Real-World Data.

BACKGROUND: Sacubitril/valsartan reduced mortality and hospitalizations in patients with heart failure with reduced ejection fraction (HFrEF) compared to enalapril in pivotal clinical trials. However,...

Frailty prediction in heart failure patients with acute infections: the potential role of thiazide diuretics?

BACKGROUND: Frailty remains a significant risk factor for adverse health outcomes in hospitalized patients. Few have evaluated frailty risk and its influencing factors in heart failure (HF) patients w...

A Dynamic Prognosis Model of Patients with Chronic Heart Failure: A Prospective Cohort Study Using Follow-Up Data and Recurrent Neural Networks.

BACKGROUND: Prediction models for mortality risk in patients with chronic heart failure (CHF) have traditionally relied on static admission data, which restricts capturing disease dynamics. Longitudin...

From conceptual emergence to multidisciplinary expansion: a bibliometric and knowledge mapping analysis of cardiovascular-kidney-metabolic syndrome research.

BACKGROUND: The concept of cardiovascular-kidney-metabolic (CKM) syndrome has recently been introduced as an integrated framework linking heart, kidney, and metabolic disorders. However, a global over...

Qualitative study on influencing factors of acceptance of advance care planning in patients with end-stage heart failure based on COM-B theory.

OBJECTIVE: Patients with end-stage heart failure (ESHF) face high mortality and complex decision-making needs, yet advance care planning (ACP) acceptance is insufficient in clinical practice. This stu...

Impact of infection on decongestion and kidney outcomes in patients with cardiorenal syndrome type 1.

BACKGROUND: Infections are frequent precipitants of acute decompensated heart failure (ADHF) and may alter decongestive trajectories in patients with cardiorenal syndrome type 1 (CRS1), it may reduce ...

Risk prediction for long-term cardiovascular events in patients with concurrent hypertension, HFpEF, and unstable angina: a multicenter machine learning-assisted cohort study.

BACKGROUND: Patients with concurrent hypertension, heart failure with preserved ejection fraction (HFpEF), and unstable angina pectoris (UAP) represent a high-risk population with heterogeneous long-t...

Endothelial epigenetic senescence driven microglial activation mediates cardio-retinal neuroinflammation in heart failure.

RATIONALE: Heart failure (HF) is increasingly recognized as a systemic disorder that extends beyond the heart and affects neurovascular tissues, including the retina. However, the mechanisms by which ...

Linear dose-response relationship between TyG-WC index and diastolic dysfunction: insights from restricted cubic spline and machine learning analysis.

BACKGROUND: While diastolic dysfunction (DD) is a critical heart failure precursor linked to metabolic stress, the specific association between the promising triglyceride-glucose waist circumference (...

Association between Circulating Interleukin-2 and Clinical Outcomes in Patients with Acute Decompensated Heart Failure.

Inflammation plays a critical role in the pathogenesis of acute decompensated heart failure (ADHF), and circulating inflammatory cytokines have been implicated in heart failure pathophysiology and pro...

Accuracy of nursing diagnoses identified at admission and discharge of patients with decompensated heart failure.

PurposeTo determine the accuracy of nursing diagnoses at hospital admission and discharge for patients with heart failure (HF).MethodsThis comparative study examined the documentation in 155 medical r...

National divergence in cardio-kidney-metabolic syndrome burden and implications for health policy: a global burden of disease analysis with projections to 2050.

BACKGROUND: The co-occurring epidemics of diabetes and obesity have increased the prevalence of Cardio-Kidney-Metabolic (CKM) syndrome. Comparative studies on long-term trends of its three core compon...

Health literacy, social support, and health activation as determinants of health-promoting behaviors in patients with chronic heart failure: a COM-B model-based path analysis.

BACKGROUND: Chronic heart failure (CHF) is a progressive and recurrent condition associated with high hospitalization rates, substantial healthcare burden, and impaired quality of life. Health-promoti...

Burden of heart failure in Asian Countries from 1990 to 2021: Update from the Global Burden of Disease Study 2021.

Heart failure (HF) remains a major public health challenge in Asia, with rising prevalence and disability burden. This study analyzed data from the 2021 Global Burden of Disease study (GBD 2021) to as...

Beyond biochemistry: multiparametric ultrasound parameters and their molecular correlates in cardio-renal-metabolic syndrome.

Cardio-renal-metabolic syndrome (CRMS)-characterized by the pathological interplay of visceral adiposity, insulin resistance, chronic kidney disease, and cardiovascular disease-affects over 90% of US ...

Nonlinear Relationship Between Lactate/Albumin Ratio and 28-Day ICU Mortality in Patients With Congestive Heart Failure: Insights Into Inflammatory and Metabolic Interplay.

BACKGROUND: Congestive heart failure (CHF) among critically ill patients is a significant cardiovascular disorder that is linked to elevated mortality rates. The lactate/albumin ratio (LAR) is a readi...

Thyroid feedback quantile-based index predicts 90-day all-cause mortality or readmission in hospitalized heart failure patients: a retrospective cohort study.

OBJECTIVE: The Thyroid Feedback Quantile-Based Index (TFQI), a recently developed indicator derived from thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels, has demonstrated prognostic ...