[Structural and functional cardiac parameters in older adults residing in a long-term social care facility.].
The aging of the population is accompanied by an increase in the prevalence of chronic heart failure, including those with preserved ejection fraction, which necessitates the early detection of struct...
Integrated NEK7-inflammasome and platelet transcriptomic signature generates mechanistic hypotheses in heart failure.
BACKGROUND: The relationship between NEK7-NLRP3 inflammasome activation and elevated platelet activity in the progression of heart failure (HF) is not well understood. Additionally, a comprehensive ge...
Mechanisms of nephroprotective action of sodium-glucose cotransporter type 2 inhibitors.
OBJECTIVE: Aim: To study the potential mechanisms underlying the beneficial nephroprotective effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors. PATIENTS AND METHODS: Materials and Methods:...
Efficacy and safety of apixaban versus warfarin in LVAD patients: A propensity-matched analysis.
OBJECTIVE: Aim: The primary endpoint was the incidence of major HRAEs. Secondary endpoints included LVAD thrombosis, stroke, major bleeding, non-central nervous system thromboembolism, and all-cause m...
Prevalence of heart failure and coronary artery disease in older adults experiencing homelessness: A systematic review and meta-analysis protocol with a consultative exercise.
BACKGROUND: Heart failure (HF) is a major global public health challenge and a leading cause of morbidity and mortality, particularly among older adults. The rising prevalence of HF is driven by aging...
Biomarkers in heart failure.
Heart failure (HF) is a leading cause of morbidity and mortality worldwide, characterized by a complex pathophysiology and heterogeneous clinical trajectories. Circulating biomarkers have progressivel...
Proteomics risk scores and mortality in heart failure: Generalizability across populations.
BACKGROUND: Heart failure (HF) is a complex syndrome with high mortality. Proteomics risk scores have shown promise in predicting mortality beyond guideline-recommended clinical tools. It is crucial t...
Effects of Vericiguat on Peripheral Vascular Function and Resting/Exercise Hemodynamics in Patients With Heart Failure With Reduced Ejection Fraction: An Exploratory Pilot Study.
BackgroundVericiguat improves outcomes in heart failure with reduced ejection fraction (HFrEF), but its vascular and hemodynamic effects remain unclear. We explored changes in flow-mediated dilation (...
Genetic Evidence for the Benefits and Risks of Glucose-Lowering Drugs on Cardiovascular-Kidney-Metabolic Syndrome: A Drug-Target Mendelian Randomization Study.
BACKGROUND: To explore the potential benefits and risks of glucose-lowering drugs on cardiovascular-kidney-metabolic (CKM) syndrome outcomes using drug-target Mendelian randomization (MR). METHODS: Ge...
Heterogeneity of eHealth literacy and treatment burden in older adults with heart failure: a multidimensional latent profile analysis.
BACKGROUND: Heart failure (HF) management imposes a substantial multidimensional treatment burden (BoT) on older adults. While digital health interventions offer potential solutions, their success hea...
The first 24-h negative fluid balance is related to lower short-term mortality but higher AKI progression in critically ill heart failure: a retrospective cohort study.
BACKGROUND: Current guidelines lack instruction on fluid administration for patients with critically ill heart failure (HF) in the intensive care unit. OBJECTIVES: This study aims to compare the risk ...
A systematic review and meta-analysis of randomized controlled trials on the effects of neuromuscular electrical stimulation in patients with acute heart failure.
BACKGROUND: Acute heart failure often leads to impaired physical function, high rehospitalization rates, and poor quality of life. Although exercise-based rehabilitation benefits chronic heart failure...
Screening for HFpEF in pacemaker patients: Study design and protocol of the PM-HFpEF study.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is common in older multimorbid patients and is associated with substantial morbidity and mortality. Pacemaker (PM) patients may be pa...
Dressing-induced hemodynamic instability in patients with heart failure: Implications for nursing care.
BACKGROUND: Heart failure (HF) restricts activities of daily living, impacting prognosis and quality of life. Dressing requires sustained upper-limb movements, postural transitions, and fine-motor tas...
2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
AIM: The "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome" retires, replaces, and expands upon the "2013 AHA/ACC/TO...
Relationship Between the Cumulative Atherogenic Index of Plasma Exposure and Incident Heart Failure.
We aimed to characterize the relationship between cumulative exposure to atherogenic index of plasma (AIP) and the risk of incident heart failure (HF) in a Chinese population.A total of 57,156 individ...
Glucose cotransporter-2 inhibitors on mortality and hospitalization in heart failure patients: a comprehensive meta-analysis.
BACKGROUND: Heart failure (HF) remains a major global health challenge, with high rates of hospitalization and mortality despite advances in therapy. Sodium-glucose cotransporter-2 (SGLT2) inhibitors,...
Hyperkalemia in Heart Failure Hospitalizations: An Underreported Contributor to Poor Outcomes and Higher Costs in Brazil.
Hyperkalemia is associated with poor prognosis in heart failure (HF), but its reporting in administrative data is likely suboptimal. The aim was to evaluate the frequency and impact of hyperkalemia IC...
CAMK2D causes heart failure in mice with RBM20 cardiomyopathy.
Although heart disease arises from different etiologies, treatment remains largely one-size-fits-all, leaving many patients without optimal benefit, which highlights the need for cause-directed therap...
Cancer and heart failure: prevalence, incidence, and prognosis in Scotland.
Many patients with cancer develop heart failure (HF), and many patients with HF develop cancer. Inter-relationships between their natural histories are rarely reported. Health records were obtained fo...