Deactivation of Cardiac Devices at the End of Life: Clinical and Ethical Challenges.
PURPOSE OF REVIEW: Device deactivation in patients with heart failure is an increasingly relevant clinical and ethical challenge as the use of cardiovascular implantable electronic devices expands. RE...
Finerenone in Heart Failure with Preserved Ejection Fraction: Expanding the Role of Non-steroidal Mineralocorticoid Receptor Antagonists.
PURPOSE OF REVIEW: To evaluate the role of finerenone, a nonsteroidal mineralocorticoid receptor antagonist (MRA), in heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF). R...
Clinical translation and engineering challenges of soft robotic cardiac sleeves for heart failure.
Soft robotic cardiac sleeves are an emerging class of non-blood-contact mechanical circulatory support devices designed to augment myocardial function while avoiding direct interaction with blood. The...
Pseudo-heart failure in pregnancy complicated by preeclampsia: giant mediastinal teratoma with extrinsic cardiopulmonary compression.
A woman in her early 20s at 30 weeks of gestation presented with elevated blood pressure, transaminitis, progressive dyspnoea, orthopnoea, exertional chest pain and peripheral oedema, raising concern ...
Berlin heart EXCOR® implantation for Fontan failure in right-sided heterotaxy with ventricular septal protuberance: autopsy case report.
A 4-year-old boy with a diagnosis of right-sided heterotaxy syndrome was transferred to our hospital under the extracorporeal membrane oxygenation (ECMO). He had undergone an extracardiac total cavopu...
Association between the Dietary Approaches to Stop Hypertension (DASH) diet and risk of incident heart failure and heart failure-related death: a UK Biobank cohort study.
BACKGROUND: Evidence supporting dietary interventions for heart failure (HF) prevention remains limited. The Dietary Approaches to Stop Hypertension (DASH) diet has been proposed as a cardioprotective...
Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls.
PURPOSE OF REVIEW: We review potential applications and pitfalls of urinary biomarkers in people with heart failure (HF). RECENT FINDINGS: Albuminuria may indicate kidney damage and guide prioritizati...
Type 2 diabetes is associated with clinical progression of aortic stenosis: a nationwide retrospective study in Sweden.
Patients with type 2 diabetes mellitus (T2DM) have elevated risk for aortic stenosis (AS). The impact of diabetes on prognosis and clinical progression in AS is not well documented. In this study we t...
Temporal changes in obstructive sleep apnea severity and body composition parameters during 6-month tofogliflozin administration in patients with heart failure and type 2 diabetes mellitus: a TOPARDS-HF substudy.
PURPOSE: Obstructive sleep apnea (OSA) is closely associated with obesity and fluid retention. Our previous study suggested that, in patients with heart failure, the sodium-glucose cotransporter 2 inh...
False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.
Cardiac amyloidosis is one of the aetiologies of treatable heart failure. Cardiac amyloidosis is rare in young patients, but it can present atypically, leading to diagnostic delays. In this case, a 33...
Are SGLT2 inhibitors really associated with increased urinary tract infection risk? A trial-level meta-analysis across type 2 diabetes, heart failure, and chronic kidney disease.
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are established therapies across the cardiovascular-renal continuum. Although the excess risk of external genital infection is well recogn...
Contemporary medical therapy for heart failure with mildly reduced or preserved ejection fraction.
Treatment for heart failure with mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) has evolved significantly in recent years. This period of therapeutic progress follow...
Ten-year incidence and heart failure dominance of hospitalized cardiovascular events in rheumatoid arthritis: a hospital-based cohort study from Martinique.
Higher risks of cardiovascular mortality and cardiovascular events have been reported in patients with rheumatoid arthritis (RA) compared with the general population. However, data remain scarce in po...
Lycium barbarum-Derived Extracellular Vesicles Ameliorate Myocardial Hypertrophy in Heart Failure with Preserved Ejection Fraction, Associated with Reduced Cardiomyocyte Apoptosis.
BACKGROUND: Non-invasive therapies for heart failure represent one of the current major focuses in clinical research. Plant-derived extracellular vesicles (PEVs) have recently emerged as a promising t...
The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.
OBJECTIVE: Patients with chronic heart failure (CHF) have a high mortality rate. The aim of this research is to examine the clinical value and molecular mechanisms of the lncRNA T cell receptor gamma ...
Association Between Heart Failure Medications and Outcomes in Patients With Cardiac Sarcoidosis and Left Ventricular Systolic Dysfunction: Insights From ILLUMINATE-CS.
BACKGROUND: Heart failure associated with cardiac sarcoidosis (CS) is typically managed using conventional heart failure medications (HFMs). However, their effectiveness in this specific population re...
Remnant Cholesterol Paradox: Higher Levels Are Associated With Reduced Mortality in Critically Ill Patients With Heart Failure.
BACKGROUND: Remnant cholesterol (RC) is a significant cardiovascular risk factor, but its prognostic value in critically ill patients with heart failure remains inadequately characterized. This study ...
Central Adiposity, Systemic Inflammation, and Incident Heart Failure: A Causal Mediation Analysis From the Jackson Heart Study.
BACKGROUND: Obesity and systemic inflammation have each been independently associated with an increased risk of heart failure (HF). However, whether inflammatory pathways mediate the association betwe...
Innovative strategies to reduce heart failure hospitalizations: insights from the ESC heart failure congress 2026.
Heart failure (HF) represents a major burden on healthcare systems globally, driven by high rates of hospitalizations and readmissions, as well as prolonged length of stay (LOS). To address this, a wi...
Mobile Integrated Health and Post-Hospital Discharge Heart Failure Care.
IMPORTANCE: Mobile integrated health (MIH) is a promising model for improving transitions of care for patients with heart failure (HF). National implementation remains limited due to insufficient unde...