A parabolic correlation between stress hyperglycemia ratio and 28-day mortality in US participants with diabetes and heart failure.

Current research lacks sufficient insight into the correlation between the stress hyperglycemia ratio (SHR) and 28-day mortality in critically ill patients with heart failure and diabetes. Our study a...

Clinical differences between destination therapy and bridge-to-transplant left ventricular assist device implantation: a 17-year single-center experience in Japan.

The use of left ventricular assist device (LVAD) implantation for destination therapy (DT) has been recently increased worldwide. In 2021, DT was also approved in Japan. Here, we report a single-insti...

Large-scale proteomics to identify novel biomarkers linking social determinants of health to heart failure risk.

Adverse social determinants of health (SDOH) associate with greater heart failure (HF) risk. Among 9879 community-based participants of the Atherosclerosis Risk in Communities (ARIC) cohort study, we ...

Hope for heart failure with preserved ejection fraction?

A common form of heart failure improves when cyclic guanosine monophosphate-dependent protein kinase is activated with a novel agent that promotes cysteine-42 oxidation.

Targeting PKGIα Cys(42) attenuates cardiac dysfunction in heart failure with preserved ejection fraction.

Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent condition associated with substantial morbidity and mortality, yet effective therapeutic options remain limited. As oxidati...

Cardiopulmonary Failure in Hantavirus Disease: Mechanisms, Recognition, and ECMO-Based Management.

Background: Hantavirus pulmonary syndrome (HPS), also designated hantavirus cardiopulmonary syndrome, is caused by New World hantaviruses, principally Sin Nombre virus in North America and Andes virus...

Semi-supervised Omics Factor Analysis (SOFA) disentangles known and latent sources of variation in multi-omic data.

A fundamental design pattern in biomolecular studies is to assay the same set of samples (organisms, tissue biopsies, or individual cells) by multiple different 'omics assays. Group Factor Analysis (G...

Feasibility and outcomes of an automated high-alert NT-proBNP pathway.

BACKGROUND: NT-proBNP is a key biomarker in heart failure (HF). Patients with markedly elevated levels are at high risk of adverse outcomes but experience delays in specialist care. Evidence on the im...

Natriuretic peptide responses to exercise in HFpEF diagnosis: a pilot study.

BACKGROUND: Diagnosing heart failure with preserved ejection fraction (HFpEF) can be challenging because natriuretic peptide (NP) plasma levels and diastolic function parameters during rest echocardio...

Combined use of SGLT2 inhibitor and GLP-1 receptor agonist versus either monotherapy for cardiorenal Outcomes: an exploratory network meta-analysis of 16 randomized trials.

BACKGROUND: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) each provide cardiorenal protection in trials of selected populations, but their...

Efficacy of multi-layered human iPS cell-derived cardiovascular cell sheets in a pacing-induced canine dilated cardiomyopathy model.

BACKGROUND: Dilated cardiomyopathy (DCM) is a progressive, intractable disease that leads to heart failure. Heart transplantation is the only curative treatment; however, access is limited by donor sc...

Association of albumin-bilirubin score with clinical severity and outcome in patients with decompensated heart failure: a retrospective cohort study.

BACKGROUND: The Albumin-Bilirubin (ALBI) score is a simple marker of hepatic function that may reflect systemic congestion in heart failure. Therefore, the present retrospective cohort study aimed to ...

[Efficacy of rescue extracorporeal membrane oxygenation combined with delayed left ventricular assist device implantation for in-hospital sudden cardiac arrest in end-stage heart failure patients].

The data of eight patients with end-stage heart failure who experienced in-hospital sudden cardiac arrest and received cardiopulmonary resuscitation (CPR), followed by extracorporeal membrane oxygenat...

Metallomic Dysregulation and Cardiovascular Disease: Essential Trace Elements, Non-essential Metal Exposure, and Heart Failure Risk: A Systematic Review.

Heart failure (HF) affects over 64 million people worldwide, with five-year mortality rates rivaling solid-organ malignancies. Despite advances in neurohormonal therapy, many patients continue to prog...

The gut microbiome and allograft outcomes: implications for heart transplantation.

Heart transplantation remains the gold standard therapy for patients with end-stage heart failure. However, post-transplant complications are considerable. Emerging evidence implicates the gut microbi...

LCN2 Associated With the Bidirectional Cardio-Kidney Link in Patients With Type 2 Diabetes and Cardiovascular-Kidney-Metabolic Syndrome.

BACKGROUND Despite the well-established epidemiological association between diabetic kidney disease (DKD) and coronary artery disease (CAD) in patients with T2DM, which reflects a core feature of card...

Integrated Bulk and Single-Cell Transcriptomic Analyses Identify a FOLR2(+) Tissue-Resident Macrophage-Associated Lysophagy Gene Module in Heart Failure.

Objectives: Heart failure (HF) arises from multiple interrelated pathological processes. Among these, lysosomal impairment and loss of autophagic homeostasis are increasingly recognized as important c...

Diagnostic accuracy of electronic medical record retrieval methods and a large language model for identifying cardiovascular events: a multisite retrospective validation study in a medical system in the United States.

OBJECTIVE: To compare the diagnostic accuracy of four available automated electronic medical record (EMR) retrieval methods, including a large language model (LLM)-assisted workflow, against manual ch...

Digital Health Technology for Improving Physical Function in Adults With Chronic Heart Failure: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BACKGROUND: Chronic heart failure (CHF) significantly impairs physical function and quality of life. Although exercise-based cardiac rehabilitation represents a primary therapeutic strategy, participa...

Association Between Gut Microbiota Dysbiosis and Bilirubin Metabolism Dysregulation in Children with Heart Failure.

Patients with heart failure (HF) demonstrate dysregulation in bilirubin metabolism. The specific characteristics of intestinal bilirubin metabolism in HF remain unclear. This study involved metagenomi...