Stepwise Targeted Screening for Familial Hypercholesterolemia in a Resource-Limited Setting: A Scalable Model Linking Premature Coronary Artery Disease and Community Screening in Vietnam.

BACKGROUND: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder associated with a substantially increased risk of atherosclerotic cardiovascular disease. In low- and middle-inco...

Response to PCSK9 Inhibition Based on LDL Receptor Function in Familial Hypercholesterolemia: A Nonrandomized Clinical Trial.

In individuals with heterozygous familial hypercholesterolemia (HeFH), it is uncertain whether and to what extent the reduction in low-density lipoprotein cholesterol (LDL-C) with proprotein convertas...

Eicosapentaenoic acid ethyl ester, cardiac metabolomic and lipidomic signatures, and cardioprotection in myocardial infarction.

The cardiovascular benefits of eicosapentaenoic acid ethyl ester (EPA-E) in MACE reduction might extend beyond its triglyceride (TG)-lowering effects. However, the mechanism behind remains unknown. Th...