Protective Effects of Mussaenda pubescens Leaf Extracts Against Oxidative Stress and Dyslipidemia.

OBJECTIVE: Mussaenda pubescens (Rubiaceae) is a medicinal plant, traditionally utilized for gastrointestinal, febrile, and reproductive ailments. This study was aimed at analyzing the antioxidant capa...

Couple-level dyslipidemia and embryological and cumulative pregnancy outcomes in IVF/ICSI cycles: a single-center retrospective cohort study.

BACKGROUND: Dyslipidemia is a metabolic factor associated with reproductive outcomes, but evidence on couple-level dyslipidemia in IVF/ICSI remains limited. OBJECTIVE: To investigate associations of d...

A high-fat/high-sucrose/high-cholesterol diet leads to early indications of metabolic dysfunction-associated steatohepatitis-like lesions in obese diabetic mice.

Chronic hyperlipidemia and/ or hyperglycemia can impair various organs, such as the liver, kidney, and pancreas, through metabolic abnormalities. Metabolic dysfunction-associated steatohepatitis (MASH...

Prevalence and Predictors of Dyslipidemia and Diabetes Mellitus Among cART-Treated HIV Patients in Western Ethiopia: A Cross-Sectional Study.

BackgroundCombination of antiretroviral therapy (cART) has improved the life expectancy of HIV patients. Yet, it can also increase the risk of metabolic dysfunction, including dyslipidemia and diabete...

Association between occupational sedentary behavior and metabolic syndrome and related diseases in males: A cross-sectional study.

BACKGROUND: Prolonged occupational sedentary behavior has become a prevalent norm in workplaces, posing significant health risks. However, there is a scarcity of studies on the association between occ...

Differences in clinical features and prognosis between hypertriglyceridemia and other causes of acute pancreatitis: a dual perspective based on metabolic disorders and inflammatory response.

BACKGROUND: To investigate the clinical features and prognosis of acute pancreatitis (AP) with different etiologies. METHODS: A total of 242 patients with AP admitted to the First Affiliated Hospital ...

Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatment.

Avasimibe, a cholesterol-lowering drug with proven safety in clinical trials, has also been repositioned as an anticancer agent in various preclinical investigations. A study from our group reported t...

Subtype-Specific Associations Between Hyperlipidemia and Age-Related Cataract: A Clinic-Based Cross-Sectional Study.

BACKGROUND: Age-related cataract (ARC) is the leading cause of global blindness in the elderly. An unbalanced metabolic state is known to contribute to lens epithelial cell dysfunction and ARC pathoge...

Exploring the Other Side of Medication: A Patient Interview Study on Anti-PCSK9 Monoclonal Antibodies.

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors demonstrate significant lipid-lowering effects, but the widespread use of anti-PCSK9 monoclonal antibodies remains limited....

Comparative efficacy of lipid-lowering therapies on the cardio-renal-metabolic axis in diabetic kidney disease: a Bayesian network meta-analysis addressing residual CRM risk.

BACKGROUND: In diabetic kidney disease (DKD), dyslipidemia accelerates renal decline and heart failure risk, making Cardio-Renal-Metabolic (CRM) risk reduction critical. The bidirectional relationship...

Patients with type 1 diabetes mellitus and recommended low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and apolipoprotein B targets - a SwissDiab study.

BACKGROUND: Cardiovascular risk in type 1 diabetes mellitus (T1DM) is frequently underestimated in daily clinical practice. The aim was therefore to evaluate lipid management in patients with T1DM acc...

Association of the planetary health diet score with obesity, high blood pressure, dyslipidemia, and cardiometabolic risk markers: Using data from the 2016-2020 Korea National Health and Nutrition Examination Survey.

Noncommunicable diseases (NCDs) remain the leading cause of death worldwide, with unhealthy diets and insufficient physical activity as major contributing factors. The Planetary Health Diet is a susta...

Sex- and Age-specific Divergent Trends in Walking, Obesity, and Hypertriglyceridemia in Middle-Aged Adults: A Joinpoint Regression Analysis, 2005-2023.

Introduction: Managing obesity and lipid levels is essential for the prevention of chronic diseases. Despite clinical guidelines emphasizing lifestyle interventions, the long-term sex- and age-specifi...

Exposure to heavy metals and trace elements and risk of dyslipidemia: a nested case-control analysis in rural adults.

BACKGROUND: Exposure to some conventional metal trace elements has been found to be associated with abnormal blood lipids; however, evidence for combined exposure is inconclusive. This study aimed to ...

Association between pan-immune-inflammation value and clinical outcomes in critically ill patients with hyperlipidemia: An observational study.

BACKGROUND: Hyperlipidemia contributes to immune-inflammatory imbalance and poor outcomes in critical illness. The pan-immune-inflammation value (PIV), derived from neutrophil, monocyte, platelet, and...

Burden and patterns of dyslipidaemia among adult Ghanaians: A systematic review.

BACKGROUND: Dyslipidaemia is a major modifiable risk factor for cardiovascular disease and has become an increasing public health concern in sub-Saharan Africa. Rapid urbanisation, dietary transitions...

Prevalence of Hyperlipidemia and Associated Factors Among People Living With HIV Attending Care at Rugazi Health Center IV, Rubirizi District South-Western Uganda.

THE PURPOSE OF THE RESEARCH: Although antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality worldwide, its long-term use is increasingly associated with metabolic ...

[Biomarkers of dysfunctional changes in high-density lipoproteins in the assessment of lipid metabolism in hyperlipidemia modeling in vivo].

UNLABELLED: High-density lipoprotein (HDL) are capable of losing their physiological functions under pathophysiological conditions and transforming into particles with pro-inflammatory activity. The a...

Obesity and dyslipidemia in patients with craniopharyngioma before and one year after surgical resection.

INTRODUCCIÓN: El craneofaringioma se caracteriza por manifestaciones clínicas derivadas de la compresión de estructuras del sistema nervioso central, deficiencias hormonales hipofisarias, así como obe...

Navigating hypertriglyceridemia in pregnancy: current evidence and clinical strategies.

Pregnancy induces profound metabolic adaptations, including marked rises in lipid concentrations. Triglyceride levels may increase by 100-300% compared with pre-pregnancy values, and in some women thi...