The Effect of Semaglutide on Antipsychotic-Induced Weight Gain and Other Metabolic Parameters, among a Cohort of Inpatients.
BACKGROUND AND HYPOTHESIS: Antipsychotic use in severe mental illnesses (SMI) is associated with metabolic dysregulation, including antipsychotic-induced weight gain (AIWG), type 2 diabetes (T2D), and...
[Effect of modified Xiangsha Liujunzi Decoction on adipose tissue browning-Nrg4-liver fatty acid synthesis pathway in rat model of both spleen deficiency and hyperlipidemia].
This study aims to investigate the effect of modified Xiangsha Liujunzi Decoction on adipose tissue browning-neuregulin 4(Nrg4)-liver fatty acid synthesis pathway in the rat model of both spleen defic...
ASSESSMENT OF THE LIPID SPECTRUM IN GEORGIAN CHILDREN WITH TYPE 1 DIABETES MELLITUS.
BACKGROUND: Children and adolescents with type 1 diabetes mellitus (T1DM) are at increased risk of future cardiovascular disease, and dyslipidemia is one of the major modifiable contributors to this r...
高甘油三酯血症未加重GPIHBP1基因敲除小鼠的胸主动脉瘤和夹层
高甘油三酯血症是动脉粥样硬化性心血管疾病的既定危险因素，最近被牵连在腹主动脉瘤的发病机制中。然而，其在胸主动脉瘤和夹层（TAAD）中的作用仍不确定。本研究利用GPIHBP1（糖基磷脂酰肌醇锚定高密度脂蛋白结合蛋白1）基因敲除小鼠作为高甘油三酯血症模型，探讨了高甘油三酯血症对实验性TAAD的影响。通过口服β-氨基丙腈在3-4周龄小鼠中诱导TAAD，持续28天。尽管GPIHBP1基因敲除小鼠在β-氨基...
前蛋白转化酶枯草杆菌蛋白酶/kexin 9型抑制剂：过去、现在和未来。
On the basis of seminal genetic discoveries, proprotein convertase subtilisin/kexin Type 9 (PCSK9) inhibitors were developed as a new class of LDL cholesterol-lowering drug, with a potency on par with...
常规公式与机器学习模型估计血清低密度脂蛋白胆固醇的比较
准确估计低密度脂蛋白胆固醇（LDL-C）对于心血管风险评估和监测至关重要。由于β定量法操作繁琐且不适用于常规使用，已开发了多种方程来估计LDL-C浓度。然而，在甘油三酯水平升高、低LDL-C或非空腹样本等临床条件下，传统方程的性能可能下降。本研究比较了常规估计公式（Friedewald、Martin-Hopkins和Sampson-Nielsen公式）与机器学习模型在估计血清LDL-C方面的性能。...
A novel LepR knockout hamster model for type 2 diabetes and its complications: a complementary platform to conventional rodent models.
BACKGROUND: Type 2 diabetes (T2D) is a progressive metabolic disorder characterized by systemic metabolic dysfunction and multi-organ complications that considerably increase morbidity and mortality. ...
Evolocumab in the treatment of refractory chylothorax induced by systemic lupus erythematosus complicated with hyperlipidemia: a case report and literature review.
Recurrent chylothorax induced by thoracic duct injury in patients complicated with mixed hyperlipidemia secondary to systemic lupus erythematosus (SLE) is rarely encountered in clinical practice. A 55...
Simulation Study on Preanalytical Variables in Coagulation Testing: Interference Effects and Threshold Determination of Hemolysis, Lipemia, Icterus and Insufficient Sample Volume.
ObjectiveTo systematically evaluate the interference degree of hemolysis, lipemia, icterus, and sample collection volume on routine test items of the ACL TOP750 automatic coagulation analyzer, assess ...
Sitosterolemia: A Rare Cause of Severe Hypercholesterolemia in Children.
INTRODUCTION: Severe hypercholesterolemia in children is commonly caused by familial hypercholesterolemia (FH); however, sitosterolemia, a rare autosomal recessive disorder, should be considered when ...
Combining MRI dual-sequence radiomics and clinical parameters predicts post-hypertriglyceridemic acute pancreatitis diabetes mellitus.
BACKGROUND: Post-acute pancreatitis diabetes mellitus (PPDM-A) represents the most prevalent subtype of diabetes secondary to exocrine pancreatic dysfunction. Patients with acute pancreatitis (AP) cau...
Prevalence, treatment rates and control of dyslipidemia among diabetes patients in northern Nigeria: A cross-sectional, multicenter study.
OBJECTIVES: Dyslipidemia is prevalent among Nigerians with diabetes mellitus (DM), but its treatment has not been well-studied. The objective of this study was to determine the prevalence, treatment r...
Hyperlipidemia Management: Comprehensive Review and Looking Forward.
Hyperlipidemia is a major risk factor of atherosclerotic cardiovascular disease and remains a major global health concern. While statins remain the cornerstone of therapy, a subset of patients require...
A multi-center, open-label, observational study to evaluate the efficacy and safety of LivaloZet(®) tablets in patients with dyslipidemia and metabolic syndrome: PIVOT study protocol.
INTRODUCTION: Dyslipidemia accompanied by metabolic syndrome substantially elevates cardiovascular risk by clustering multiple risk factors, including abdominal obesity, hypertension, hyperglycemia, a...
Acute pancreatitis during pregnancy: maternal and fetal outcomes in a five-case series.
Pregnancy-related acute pancreatitis (AP) is an uncommon but potentially life-threatening condition for both the mother and the fetus. The most frequent causes are biliary lithiasis and hypertriglycer...
Anthropometric and Metabolic Traits Across Ancestries in the UK Biobank.
AIMS: Increased waist-hip ratio (WHR) increases free fatty acid (FFA) flux, contributing to dysglycemia and dyslipidemia in Europeans. We examined these phenomena in non-Europeans, a group with higher...
Epidemiology and determinants of dyslipidemia in Iranian population: Results from the PERSIAN cohort.
BACKGROUND: Dyslipidemia is one of the main risk factors for cardiovascular diseases worldwide. The current study aimed to determine the prevalence and correlates of dyslipidemia in Iran, in addition ...
Treatment of mild subclinical hypothyroidism and its impact on lipid metabolism.
BACKGROUND: Hypothyroidism, both overt and subclinical, is associated with dyslipidemia and increased cardiovascular risk which is not completely corrected by thyroid hormone replacement therapy. In p...
A One-Year Retrospective Observational Study Reveals the Transient Nature of Pemafibrate-Induced LDL-C Elevation: Implications Beyond the PROMINENT Trial.
PURPOSE: Pemafibrate, a selective peroxisome proliferator-activated receptor-α modulator (SPPARMα), is widely used for hypertriglyceridemia; however, concerns persist regarding its potential to elevat...
Early prediction of late-pregnancy hypertriglyceridemia in women with gestational diabetes: development and internal validation of a clinical risk model.
BACKGROUND: Women with gestational diabetes mellitus (GDM) are at high risk of developing hypertriglyceridemia (HTG) in late pregnancy, a condition associated with adverse maternal and neonatal outcom...