Personalised approach to hypertension treatment: protocol for the HYPERMARKER randomised controlled trial.
INTRODUCTION: Blood pressure treatment response is variable in individual patients, and the choice of medical therapy is often dependent on clinician experience. Treatment choices could be personalise...
Implementation of a learning health system for the management of non-communicable diseases in Thailand: a realist evaluation protocol.
INTRODUCTION: Learning health systems (LHS) are an approach to translate patient data into actionable clinical insights, empower healthcare teams to drive quality improvement and reduce health inequal...
Lifestyle and metabolic determinants of early- and late-onset colorectal cancer: insights from a tertiary medical center in Alabama.
PURPOSE: Early-onset colorectal cancer (EOCRC, < 50 years) is rising in the United States, whereas late-onset CRC (LOCRC, ≥ 50 years) is declining. Fewer studies have examined association between risk...
Genetic evidence links hypertension to accelerated brain aging.
Hypertension affects one-third of adults and is a major comorbidity of neurocognitive disorders. The causal relationship, shared genetic architecture, and upstream mechanisms linking hypertension to b...
Serum Pancreatic Stone Protein Across the Spectrum of Hypertensive Disorders of Pregnancy: Discrimination of Preeclampsia Compared with Conventional Inflammatory Indices.
Background and Objectives: Hypertensive disorders of pregnancy (HDP), including gestational hypertension (GHT) and preeclampsia (PE), share clinical features but differ in pathophysiology and risk pro...
Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes.
BACKGROUND: Whether primary aldosteronism (PA), the most common endocrine cause of hypertension (HTN), contributes to HTN and cardiovascular disease burden in systemic sclerosis (SSc) has never been e...
Application of AI in Hypertension Health Education: Scoping Review.
BACKGROUND: Hypertension is a major global health challenge, and effective health education is crucial for improving patients' self-management. Traditional health education approaches are often limite...
Reliability and device objectivity in oscillatory blood pressure measurement - a measurement error analysis to inform clinical decision making.
The implementation of different hypertension thresholds (e.g. ESC/ESH: 140:90 or ACC/AHH: 130:80) substantially increased hypertension prevalence donation of pharmacological treatment across various p...
Blood pressure management in reperfused ischemic stroke.
RATIONALE: Stroke is the second leading cause of death worldwide and a major contributor to disability, with ischemic strokes accounting for 80% to 85% of all strokes. Appropriate blood pressure manag...
Association Between Total Cholesterol-to-High-Density Lipoprotein Ratio and Gestational Hypertension: A Case-Control Study.
BACKGROUND While dyslipidemia has been implicated in gestational hypertension (GH), individual lipid parameters show inconsistent associations. The total cholesterol to high-density lipoprotein choles...
Transforming Pulmonary Arterial Hypertension: Key Milestones and Future Perspectives.
Pulmonary arterial hypertension (PAH) is a rare, progressive disease of the precapillary pulmonary arteries, characterized by fibroproliferative vascular remodeling, increased pulmonary vascular resis...
Interleukin-6 is critical in the development of pulmonary vascular disease in Gcn2-deficient mice.
Biallelic mutations in EIF2AK4, encoding Eukaryotic Translation Initiation Factor 2α kinase 4 or General Control Nonderepressible 2 (GCN2), cause pulmonary veno-occlusive disease (PVOD), a fatal form ...
Race and Ethnicity, Hypertension, and Neuroimaging Markers of Brain Aging: A Causal Mediation Analysis in the HABS-HD Study.
BACKGROUND AND OBJECTIVES: The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing the...
Nationwide Population-Based Cohort Study of Advanced Maternal Age and Obstetric Outcomes in Korean Women: Retrospective Cohort Study.
BACKGROUND: The proportion of mothers older than 35 years is increasing; however, research examining the age at which pregnancy is considered high risk across different races and countries is limited....
Pre- and post-operative metabolic profile of patients with pheochromocytoma: A retrospective multicenter study.
PURPOSE: To evaluate the metabolic dysregulation of patients with pheochromocytoma and their metabolic evolution after tumor resection. METHODS: This multicenter, retrospective study included individu...
Are Direct-Acting Antivirals Effective and Safe for Hepatitis C Patients with Arterial Hypertension? Evidence from a Large Retrospective Real-World Study.
Background/Objectives: Arterial hypertension (AH) and hepatitis C virus (HCV) infection are interlinked, with AH increasing the risk of severe liver disease and HCV contributing to cardiovascular issu...
[Dyspnea, pulmonary mosaic sign and pulmonary hypertension].
This case report presents a young female patient whose chief complaint was exertional dyspnea. Right heart catheterization confirmed severe pulmonary hypertension. Concurrently, chest CT showed atypic...
A systematic review of patient decision aids for hypertension.
BACKGROUND: Hypertension is a major cause of premature death and a modifiable risk factor for cardiovascular disease. Effective management includes both pharmacological treatment strategies, including...
Night shift work as a potential risk factor for hypertensive disorders of pregnancy: the Japan environment and children's study.
OBJECTIVE: This study aimed to clarify the relationship between the night shift work and hypertensive disorders of pregnancy (HDP). Moreover, we examined whether night shift work is associated with ea...
Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation.
We previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to allergen exposure or to hypoxia. To evaluate th...