Visit-to-visit systolic blood pressure variability, blood pressure treatment intensity, and cognitive decline.

INTRODUCTION: Visit-to-visit blood pressure variability (BPV) may be associated with cognitive decline beyond mean blood pressure (BP), but its relevance across treatment contexts remains uncertain. M...

The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.

INTRODUCTION: Vascular risk factors (VRFs) contribute to white matter microstructural degeneration, but their tract-specific contributions are unclear. We assessed the independent associations of four...

The Serum Testosterone Level in Male Patients Is Inversely Associated With Hypertension Incidence.

Hypertension is a primary risk factor for cardiovascular diseases and all-cause mortality. Testosterone, the most potent androgen in males, regulates reproduction, metabolism, and erythropoiesis. Hype...

Dementia Risk With Combined Statin and Antihypertensive Drugs That Increase Versus Decrease Angiotensin-II Formation: Findings From the 45 and Up Study.

BACKGROUND: Hypertension and dyslipidaemia are key modifiable risk factors of dementia, and the combined use of statins and antihypertensive medications (AHMs) may offer protective benefits. However, ...

Abdominal fat thickness predicts the risk of pregnancy-associated hypertension: A prospective cohort study.

BACKGROUND AND OBJECTIVES: Pregnancy-associated hypertension (PAH) is a prevalent complication during pregnancy. Maternal obesity is a known risk factor for PAH. As nutrition is a key modifiable drive...

Real-World Data-Driven Insights in Obesity: A Comparative Cross-Sectional Analysis of General Practice and a Specialized Obesity Clinic in Belgium-An IMI2 SOPHIA Study.

There is a lack of knowledge on the registration of body mass index (BMI) and prevalence of obesity-related complications in the Belgian healthcare system. We therefore evaluated these in Belgians liv...

Genistein inhibits oxidative stress and alleviates vascular remodeling in hypertension through the GSK3β/FYN/Nrf2 pathway.

Hypertension raises cardiovascular risk via vascular remodeling, worsened by oxidative stress-linked VSMC dysfunction. Genistein (Gen), an antioxidant isoflavone, protects against cardiovascular disea...

Emerging Strategies for Cardio-Renal Protection Beyond RAAS Blockade: Emphasis on Non-diabetic CKD and Resistant Hypertension.

Non-diabetic chronic kidney disease (ND-CKD) complicated by resistant hypertension remains a high-risk phenotype even when renin-angiotensin system blockade is optimized. This review synthesizes conte...

Optimizing Antihypertensive Care for Tanzanians Living With HIV: Effectiveness Outcomes From the COACH Pilot Trial.

BACKGROUND: In Tanzania, many people living with HIV have uncontrolled hypertension, yet integration of hypertension management into HIV care remains limited. The Community Health Worker Optimization ...

[Clinical characteristics of patients undergoing major orthopaedic surgery in a real-world clinical practice: a physician's perspective].

AIM: To evaluate the prevalence of risk factors in patients undergoing large joint arthroplasty in real-world practice. MATERIALS AND METHODS: Medical history, information about concomitant diseases a...

[Aldosterone: mechanisms of normal and impaired regulation and the possibility of their correction in arterial hypertension. Consensus of Russian Medical Society on Arterial Hypertension (RSH) experts].

In recent years, studies have been carried out that have expanded the understanding of the role of pathophysiological mechanisms underlying impaired regulation of aldosterone and activation of mineral...

Impact of Internet-Based Pharmacy Care on Patient-Reported Outcomes in Congenital Heart Disease-Associated Pulmonary Hypertension in Yunnan, China.

This study evaluated the effectiveness and cost-effectiveness of Internet-based pharmaceutical care (IPC) incorporating patient-reported outcomes (PROs) in postoperative patients with pulmonary arteri...

Association and causality between triglycerides and hypertension: evidence from NHANES 2007-2018 and two-sample Mendelian randomisation analysis.

BACKGROUND: Hypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. However, existing studies are limited, and the association remains unclear ...

Wearable Devices for Monitoring and Management of Comorbid Obstructive Sleep Apnea and Hypertension: Scoping Review.

BACKGROUND: As an established driver of hypertension, obstructive sleep apnea (OSA) generates a significant cardiovascular burden when both disorders are present. This intersection not only compromise...

Hypertensive disorders of pregnancy and GLP-1 receptor agonist timing: a systematic review and meta-analysis.

PURPOSE: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), used to treat type 2 diabetes and obesity, may improve metabolic health before conception. However, their association to hypertensive di...

Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala.

BACKGROUND: Hypertension is a leading global cause of morbidity and mortality, especially in low- and middle-income countries, where low healthcare access limits diagnosis and treatment. Community hea...

Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study.

OBJECTIVES: The intrauterine environment may influence childhood immune-mediated disease risk. We investigated whether maternal prepregnancy body mass index (BMI), gestational weight gain (GWG) or hyp...

Care Partner Perspectives on Hypertension Management in Alzheimer Disease and Related Dementias in an Online Forum: Qualitative Thematic Analysis.

BACKGROUND: Family care partners manage care for individuals with Alzheimer disease and related dementias (ADRD), including hypertension management crucial for preventing cognitive decline. Nurses fre...

Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study.

BACKGROUND AND OBJECTIVES: Genetics represent a nonmodifiable risk factor for Alzheimer disease (AD), with 60%-80% heritability. Midlife hypertension is a modifiable risk factor for both dementia and ...

Support needs for chronic disease self-management among persons attending a Primary Health Care facility in Victor Khanye, Mpumalanga.

BACKGROUND:  With the increasing burden of non-communicable chronic diseases, it is important to empower people to self-manage their conditions. This study aimed to explore the support that persons li...