Effect of a Very-Low-Protein Diet Supplemented with Ketoacid Analogues on Arteriovenous Fistula Maturation and Endothelial Function: A Prospective Observational Study.
BACKGROUND: Arteriovenous fistula (AVF) maturation is a critical determinant for successful hemodialysis in patients with end-stage renal disease (ESRD). Endothelial dysfunction and arterial stiffness...
Development of an Integrated CE-Cell-SELEX Strategy for Rational Selection of Human Bone Microvascular Endothelial Cell Aptamers.
Capillary electrophoresis (CE) has proven to be an effective technique for aptamer selection. Here, we directly integrated the separation advantages of CE into a live-cell system, thereby establishing...
METTL14 Regulates Adipose Tissue Macrophage Polarization via JAK2/STAT3 Pathway to Attenuate Obstructive Sleep Apnea-Related Systemic Inflammation.
The role of m6A RNA methylation in obstructive sleep apnea (OSA)-related metabolic dysfunction and systemic inflammation is unknown. We aimed to identify the key m6A regulator involved in OSA-induced ...
[Wellens syndrome and U-wave inversion during angina].
The authors present a case where the admission ECG showed extensive deep negative U-waves in the precordial leads, in addition to the precordial negative T-waves characteristic of Wellens syndrome. Af...
Single-Nucleus Profiling Reveals a BBB Senescence Unit Driving AD Pathology in Human Brain.
Cellular senescence contributes to Alzheimer's disease (AD) and involves the neurovascular unit, but the molecular mechanisms of cellular senescence in AD pathogenesis remain incompletely understood. ...
Peritoneal dialysis in patients with heart failure - The Italian reality based on the Census 2024 of the Peritoneal Dialysis Project Group of the Italian Society of Nephrology.
Peritoneal dialysis has shown to reduce days of hospitalization, NYHA functional class and to improve slightly left ventricular ejection fraction in heart failure patients. For the first time, the nat...
TASC-SwinMT: Task-Adaptive Synergistic Cross-Task Swin Multi-Task Framework for CT and MRI Image Interpolation and Segmentation.
Background: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) interpolation and segmentation are critical for clinical diagnosis, anatomical quantification and personalized treatment. Most...
Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy.
Thirteen new decaline polyketides, namely, zosteropenillines T-W (1-4), 8-hydroxypallidopenilline A (5), 13-epi-zosteropenilline P (6), 11-epi-zosteropenilline N (7), 15-hydroxyzosteropenilline M (8),...
Peripartum-Associated Heart Failure Develops Independently of RHOT Proteins.
Pregnancy-associated hemodynamic overload and hormonal changes induce hypertrophy and metabolic remodeling of the maternal heart. Mitochondrial motility, mediated by ras homolog family member T (RHOT)...
Exercise Improves Atherosclerotic Plaque Stability Through Macrophage Autophagy and the FGF21 Signaling Pathway.
Atherosclerosis (AS) is a major driver of acute cardiovascular events, yet the mechanisms by which exercise stabilizes atherosclerotic plaque remain poorly understood. This study investigated the prot...
Food-Derived Elastin Peptides Improve Glucose Metabolism and Protect Renal Vasculature in Stroke-Prone Spontaneously Hypertensive Rats Despite Modest Dipeptidyl Peptidase 4 Inhibition.
BACKGROUND/OBJECTIVES: Elastin-derived peptides (EPs) from food sources may be multifunctional dietary components that support metabolic and vascular health. However, their in vivo physiological actio...
Age-Related Platelet Cox-1 Upregulation in Atrial Fibrillation.
Aging is associated with enhanced platelet activation that may contribute to the occurrence of cardiovascular events. However, the mechanism linking aging with platelet activation is not fully underst...
MicroRNA-155 at the crossroads of inflammation and vascular dysfunction in essential hypertension.
MicroRNA-155 (miR-155) has emerged as a pivotal regulator in the development of hypertension. However, its role in the mechanism underlying hypertension remains incompletely defined, especially in vas...
The Heart Rhythm Society statement on the Reliance high-impedance advisory recommended shared decision-making regarding lead management decisions given concerns of risk associated with extraction from...
Association between PRECISE-DAPT score and clinical Outcomes: a subgroup analysis of the DAPT-TR registry.
OBJECTIVE: This study aimed to evaluate whether a PRECISE-DAPT score ≥ 25 identifies a high-risk phenotype associated with adverse ischemic and bleeding outcomes, hospitalisation, and mortality among ...
Isolation, Synthesis, and Characterization of CD47- and Integrin α4/β1-Modified Macrophage Membrane-Coated Poly(lactic-co-glycolic acid) Nanoparticles.
Atherosclerosis is a chronic inflammatory disease and a major contributor to cardiovascular morbidity and mortality. Targeted delivery of anti-inflammatory agents to atherosclerotic sites remains a si...
Red Blood Cell Distribution Width and Stent Length Predict In-Stent Restenosis After Myocardial Infarction: A Retrospective Cohort Study.
This study investigated the predictive value of red blood cell distribution width (RDW) stent length for in-stent restenosis (ISR) drug-eluting stent implantation in patients with acute myocardial inf...
Enhancing Patient-Centered Home Palliative Care for Heart Failure: A Concept Analysis to Guide Nursing Practice and Care Coordination.
To identify and describe components of the home-based palliative care model for patients with heart failure, re-conceptualize the process, and update the existing model to inform nursing research and ...
Mechanisms of Shengxian Quyu Decoction In Heart Failure Using an Untargeted Metabolomics and Network Pharmacology Approach In Rats.
Shengxian Quyu decoction (SXQY) has been suggested as a potential therapeutic strategy for heart failure (HF), but its therapeutic mechanisms remain unclear. This study investigated the therapeutic ef...
Transtail Artery Hepatic Artery Catheterization In Rats Under Direct Vision: A Radiation-Free Method For Establishing Animal Models.
Rat liver tumor models are indispensable for studying trans-arterial chemoembolization (TACE), drug delivery, and tumor biology. However, conventional techniques utilizing fluoroscopy-guided carotid o...