Atherosclerotic plaques preferentially form at the vascular bifurcations and inner curvature of the aortic arch, where oscillatory shear stress (OSS) induces endothelial cell (EC) inflammation, which ...

miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.

Endothelial cell dysfunction is the initial step in atherosclerosis, in which gap junction proteins such as connexin 40 (Cx40) might play an important role. Previously, we could demonstrate that miRNA...

[Establish a Zebrafish Atherosclerosis Model Screening Platform to Evaluate the Therapeutic Effects of Qi-Regulating and Blood-Activating Prescriptions on Atherosclerosis].

OBJECTIVE: To systematically identify traditional Chinese medicine (TCM) compound formulas with anti-atherosclerosis (AS) potential using a screening platform based on multi-strain apoeb gene knockout...

[Study on the Mechanism by Which Atorvastatin Enhances the Stability of Atherosclerotic Plaques in ApoE(－/－) Mice Through Regulation of MMP-7/Gα13].

OBJECTIVE: To explore the pleiotropic molecular mechanisms by which atorvastatin (Ator) regulates atherosclerosis (AS) in ApoE－/－ mice. METHODS: Thirty 8-week-old male ApoE－/－ mice were induced to dev...

[Capacity Management During the Hospital-to-Home Transition Period for Patients With Chronic Heart Failure].

OBJECTIVE: Exploring the effects of the hospital-to-home transitional capacity management plan in patients with chronic heart failure. METHODS: Patients with chronic heart failure who were hospitalize...

[Integrating Bioinformatics and Machine Learning Algorithms to Screen Inflammatory Biomarkers for Atrial Fibrillation and Experimental Validation].

OBJECTIVE: To identify potential biomarkers of atrial fibrillation (AF) using bioinformatics, machine learning (ML) and experimental methods. METHODS: AF transcriptomic data were obtained from the GEO...

[Study of the Correlation Between MRI Parameters, Microvascular Density, and Prognosis in Glioma].

OBJECTIVE: To analyze the correlations between multimodal MRI examination parameters - apparent diffusion coefficient (ADC), cerebral blood flow (CBF), and choline (Cho)/creatine (Cr)-and microvessel ...

SAM68 is a multifunctional post-transcriptional regulator of cardiomyocyte differentiation.

RNA-binding proteins (RBPs) of the STAR family play key roles in mammalian development, yet their contributions to lineage specification remain incompletely understood. Here, using CRISPR-Cas9 knockou...

[A case of acetaminophen-induced cholestatic liver injury accompanying severe hypercholesterolemia in children].

虽然对乙酰氨基酚（APAP）引起的肝损伤已有广泛报道，但关于APAP导致的严重高胆固醇血症的文献有限。现报道１例伴有严重高胆固醇血症的对乙酰氨基酚致胆汁淤积性肝损伤，在临床诊治中具有参考意义。.

[Research progress on the pathogenesis and clinical treatment of cirrhotic cardiomyopathy].

Liver cirrhosis is often accompanied by cardiovascular lesions, including hyperdynamic circulatory states and myocardial lesions. The hyperdynamic circulatory state manifests as increased cardiac outp...

[Melatonin alleviates cardiomyocyte necroptosis in diabetic mice by inhibiting the STING signaling pathway].

OBJECTIVES: To investigate the protective effect of melatonin against diabetic cardiomyopathy (DCM) and whether melatonin regulates cardiomyocyte necroptosis and inflammatory response through the stim...

[Growth differentiation factor 11 attenuates hypoxia/reoxygenation injury in rat H9C2 cardiomyocytes in vitro by inhibiting thioredoxin-1 nitrative inactivation].

OBJECTIVES: To verify the hypothesis that growth differentiation factor 11 (GDF11) attenuates myocardial ischemia/reperfusion (MI/R) injury and explore the underlying mechanism. METHODS: To simulate M...

Development and validation of a machine learning-based model for assessing coronary artery disease risk in postmenopausal women: a dual-center retrospective study.

OBJECTIVES: To investigate the risk factors of coronary heart disease (CHD) and develop a risk assessment model for CHD in postmenopausal women. METHODS: General information, medical history, and labo...

Factors Associated With Glycemic Variability in Hospitalized Patients With Type 2 Diabetes Mellitus and Heart Failure.

AIMS/BACKGROUND: Patients with concomitant heart failure (HF) and type 2 diabetes mellitus (T2DM) are at high risk for adverse clinical outcomes. Glycemic variability (GV) has emerged as a crucial met...

Experimental studies suggest that some preservative food additives may exert adverse cardiovascular effects, yet human data are lacking. The associations between exposure to these compounds and incide...

The Impact of L Arginine's Anti-Apoptotic, Anti-Inflammatory, and Anti-Fibrotic Effects in Modulating Diabetic Cardiomyopathy: The Role of microRNA-155b in the Diagnosis of Diabetic Cardiomyopathy.

Diabetic cardiomyopathy (DC) is a serious health issue. MicroRNA-155b expression dysregulation might be involved in the fibrotic cycle in DC. L-Arginine (l-arg) is reported to have a preferable impact...

LRG1 as a Potential Therapeutic Target in Atherosclerosis: Mechanistic Basis and Current Evidence.

Atherosclerosis (AS) is a chronic inflammatory disease of large arteries. It underlies many cardiovascular disorders, including coronary artery disease, myocardial infarction, stroke, and peripheral a...

Association of Relative Pericoronary Adipose Tissue Attenuation with Coronary Artery Calcification Severity.

Background and Objectives: Pericoronary adipose tissue (PCAT) attenuation measured on coronary CT angiography is a promising imaging biomarker of coronary inflammation; however, absolute values may be...

Patients with premature coronary artery disease (CAD) have high rates of recurrent events and death. Information on long-term adherence to lipid-lowering therapy (LLT) and trends in medication-taking ...

Coronary flow reserve reflects microvascular function, whereas filling pressure indicates myocardial hemodynamic burden. In angina with nonobstructive coronary arteries, abnormalities in either could ...