Cardiac tertiary immune niches drive immune activation in immune checkpoint inhibitor myocarditis.
Immune checkpoint inhibitor (ICI) myocarditis is a rare but frequently fatal immune-related adverse event of cancer immunotherapy. Understanding the mechanisms of this toxicity is critical to balancin...
Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart.
The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear....
The structure of the native cardiac crossbridge in the rigor state.
Cardiac contraction is driven by double-headed myosin cycling on cardiac thin filaments, where troponin-tropomyosin regulates myosin access to actin. Prior high-resolution structural studies used a si...
Antiarrhythmic Drug Therapy in Cardiomyopathies: A Comparative Synthesis of Guidelines and Consensus Documents.
PURPOSE OF REVIEW: Antiarrhythmic drug therapy in cardiomyopathies remains challenging because arrhythmic risk, drug efficacy, and pro-arrhythmic vulnerability vary substantially across phenotypes. Th...
A Validated, explainable machine learning-based preoperative risk model for microvascular invasion in hepatocellular carcinoma.
PURPOSE: This investigation aimed to develop and validate a diagnostic algorithm for preoperatively assessing the likelihood of microvascular invasion (MVI) in patients with hepatocellular carcinoma (...
Community-Based Hypertension Screening to Prevent Stroke in Underserved Urban Neighborhoods in French Guiana: Protocol for a Quasi-Experimental Study.
BACKGROUND: Hypertension is a leading contributor to stroke and cardiovascular disease in underserved populations. OBJECTIVE: This study aims to evaluate a community-based hypertension screening inter...
Opioid Use for Dyspnoea in Advanced Heart Failure.
PURPOSE OF REVIEW: This narrative review aims to provide an overview of the available evidence on opioid use for refractory dyspnoea in advanced heart failure, focusing on mechanisms, effectiveness, s...
SREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure.
Myocardial infarction-induced heart failure (MI-HF) remains a major contributor to cardiovascular mortality, yet the molecular mechanisms underlying its progression, particularly those involving ferro...
SGLT2 inhibitors activate pantothenate kinase in the human heart.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothen...
tRNA-derived small RNAs in vascular smooth muscle cell phenotypic switching and vascular remodelling.
tRNA-derived small RNAs (tsRNAs) are noncoding RNAs generated from precursor or mature tRNAs. Basal tsRNA levels are detectable under physiological conditions, but their production increases sharply u...
Short-term retinal microvascular and structural changes after epi-on and epi-off corneal cross-linking assessed by SD-OCTA.
PURPOSE: To evaluate and compare short-term retinal microvascular and structural changes following ultraviolet-A (UVA) exposure in corneal cross-linking (CXL) procedures with and without epithelial re...
A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins.
Lipoproteins are essential for lipid transport in all bilaterians. A single Apolipoprotein B (ApoB) molecule is the inseparable structural scaffold of each ApoB-containing lipoprotein (B-lps), which a...
[Primary aldosteronism in resistant hypertension unmasked by a thiazide-induced severe hypokalaemia].
Primary aldosteronism is the most common cause of secondary hypertension but remains frequently underdiagnosed in primary care. We report a 71-year-old man with resistant hypertension and low-normal s...
Altered bone marrow niche forms central innate immune memory driving cardiac dysfunction.
We previously showed that heart failure induces innate immune memory in hematopoietic stem and progenitor cells, which contributes to recurrence of heart failure and impaired stress responses in multi...
Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties.
This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, struc...
Role of bacterial pathogens and toxins in sepsis-related myocardial injury: a scoping review.
OBJECTIVES: To map and synthesise human and experimental literature examining associations between specific bacterial pathogens or toxins and myocardial injury in adult sepsis and to evaluate whether ...
Multimorbidity burden and hospitalisation outcomes in heart failure: a retrospective cohort study using Indonesian national health insurance claims data (2019-2024).
BACKGROUND: The expansion of universal health coverage (UHC) in many low- and middle-income countries (LMICs) has occurred alongside a growing burden of chronic disease and multimorbidity. Heart failu...
Severe multivessel coronary artery spasm presenting as very high-risk acute coronary syndrome.
Coronary artery spasm is an important cause of myocardial ischaemia and acute coronary syndrome in the absence of obstructive coronary artery disease. Simultaneous multivessel epicardial coronary arte...
Berberine-associated lipid-inflammatory regulation in atherosclerosis: an integrative transcriptomic, single-cell, and in vivo study.
Atherosclerotic plaques combine disturbed lipid metabolism with myeloid inflammation, yet the human plaque context of berberine (BBR)-related targets remains poorly defined. Paired GSE43292 samples we...
Occupational Physical Activity and Hypertension: A Narrative Review.
PURPOSE OF REVIEW: To summarize the prospective and experimental evidence examining occupational physical activity (OPA) and hypertension-related outcomes, discuss potential physiological mechanisms, ...