Hypoxia-Driven Mechanisms in Ischemic Heart Failure: A Bioinformatics, Machine Learning and Bayesian Network Study.
Hypoxia is a critical determinant in the etiology and progression of ischemic heart failure, but its underlying molecular mechanisms and regulatory interactions remain largely enigmatic. in our study,...
The long road to recognition: a historical review of amyloidosis from early pathology to disease-modifying therapy.
Within the last several decades, great strides are being made in both the diagnosis and treatment of cardiac amyloidosis, yet the condition itself has been a severely under-recognized cause of heart f...
Exercise and Endothelial Function: Insights from a Redox Perspective.
PURPOSE OF REVIEW: This review aims to synthesize the evidence linking exercise, redox regulation, and endothelial function. It considers the effects of different modes of regular exercise, acute exer...
A robotic simulation platform for fluoroscopy-guided catheter navigation in transcatheter tricuspid valve intervention: system development and proof-of-concept applications.
Robot-assisted transcatheter tricuspid valve intervention requires operators to manipulate a flexible catheter through a robotic interface while interpreting two-dimensional fluoroscopic images. Howev...
SARS-CoV-2 disrupts the integrity of a human blood-brain barrier model in the absence of infection.
Neurological symptoms are recognized in patients with COVID-19, and include anosmia, ageusia, cognitive impairments as well as more severe complications including encephalitis and ischemic strokes. Fu...
Cellular Prion Protein as a Novel Regulator of Vascular Plexus Stability During Retinal Angiogenesis.
Angiogenesis is essential not only during embryogenesis but also in adult physiology and disease, relying on vascular endothelial growth factor (VEGF) gradients to guide tip cell sprouting. Cellular p...
Arboviral infections of the central nervous system: Mechanisms of invasion and long-term consequences.
Arboviruses are a diverse group of vector-borne viruses that cause significant global morbidity and mortality. Beyond classical systemic and febrile symptoms, many arboviruses can induce a spectrum of...
A refined subclavian cardiac puncture method for longitudinal blood collection in mice.
Murine blood sampling is essential for pharmacokinetic research and chronic disease modeling. However, conventional techniques such as tail vein or retro-orbital blood collection have low sample volum...
[Numerical simulation of coping strategies for the "bird-beak" phenomenon in thoracic endovascular aortic repair].
This study aims to explore the effects of different surgical strategies on the "bird-beak" phenomenon during thoracic endovascular aortic repair (TEVAR), so as to provide a theoretical basis for clini...
[A study on three-dimensional reconstruction of coronary arteries and numerical simulation of fractional flow reserve based on deep learning].
To address the needs of geometric modeling and hemodynamic analysis in the noninvasive functional assessment of coronary heart disease, this study establishes a deep learning-based integrated framewor...
Identification of Aging and Mitochondria-Related Hub Genes in Dilated Cardiomyopathy.
Dilated cardiomyopathy (DCM) is characterized by left ventricular dilation and systolic dysfunction and is associated with mitochondrial dysfunction and immune-inflammatory activation. However, aging-...
Bioinformatics and Machine-Learning Identification of Pulmonary Hypertension Biomarkers and Candidate Therapeutic Compounds.
This study aimed to identify pulmonary hypertension (PH)-associated molecular biomarkers and candidate small-molecule compounds using public transcriptomic data and independent validation resources. T...
Longitudinal multimodal assessment of peripheral nerve involvement in wild-type transthyretin amyloidosis.
INTRODUCTION: Wild-type transthyretin amyloidosis (ATTRwt) is a progressive disease marked by extracellular transthyretin amyloid deposition, predominantly causing cardiomyopathy. Neurological manifes...
Neonatal outcome in macrosomia and gestational diabetes mellitus depending on the definition of macrosomia: a retrospective cohort study.
INTRODUCTION: Gestational diabetes increases the risk of neonatal macrosomia, which is associated with maternal and neonatal morbidity. However, the definition of macrosomia is inconsistent and includ...
Efficacy and safety of glucagon-like peptide-1 receptor agonists for diabetic cardiomyopathy: a protocol for systematic review and meta-analysis.
INTRODUCTION: Diabetic cardiomyopathy (DCM) is an important contributor to heart failure and death in patients with diabetes. Current management strategies mainly focus on glycaemic control and sympto...
Peripheral artery disease in patients with persistent claudication after lumbar spine surgery: a primary care reassessment framework.
Persistent claudication after lumbar spinal surgery may reflect unrecognised peripheral artery disease (PAD) and delayed implementation of secondary cardiovascular prevention. Despite effective guidel...
Shoshin beriberi with severe lactic acidosis and haemodynamic collapse due to long-term diuretic therapy.
A patient on long-term diuretic treatment for pulmonary arterial hypertension presented with acute haemodynamic instability and profound high anion gap metabolic acidosis. Investigations showed severe...
Medication Non-Adherence in Resistant Hypertension: Detection, Drivers, and Practical Solutions.
PURPOSE OF REVIEW: Most patients with hypertension cannot reach goal blood pressure with lifestyle modification alone, so hypertension control relies heavily on patients taking medications as prescrib...
Feasibility and Preliminary Efficacy of a "Sit Less" Program Leveraging Fitbit Tracking and Tailored Text Messages in Cardiometabolic Disease: Findings From 2 Parallel Randomized Controlled Trials in Coronary Artery Disease and Type 2 Diabetes.
BACKGROUND: Individuals with cardiometabolic disease typically average 10 to 14 hours of daily sedentary time, which increases the risk of cardiovascular disease. OBJECTIVE: This study aimed to evalua...
Combined antithrombotic therapy vs. oral anticoagulation alone for ischemic stroke with concomitant atrial fibrillation and large artery atherosclerosis: a systematic review and meta-analysis.
BACKGROUND: Treating ischemic stroke patients who have both nonvalvular atrial fibrillation (NVAF) and large artery atherosclerosis (LAA) presents a clinical challenge. It remains unclear whether addi...